Search Results - "Lai, Johnathan"

Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma by Simeoli, Raffaele, Montague, Karli, Jones, Hefin R., Castaldi, Laura, Chambers, David, Kelleher, Jayne H., Vacca, Valentina, Pitcher, Thomas, Grist, John, Al-Ahdal, Hadil, Wong, Liang-Fong, Perretti, Mauro, Lai, Johnathan, Mouritzen, Peter, Heppenstall, Paul, Malcangio, Marzia

“…Following peripheral axon injury, dysregulation of non-coding microRNAs (miRs) occurs in dorsal root ganglia (DRG) sensory neurons. Here we show that DRG…”
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Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents by Stein, C.A, Hansen, J. Bo, Lai, Johnathan, Wu, SiJian, Voskresenskiy, Anatoliy, Høg, Anja, Worm, Jesper, Hedtjärn, Maj, Souleimanian, Naira, Miller, Paul, Soifer, Harris S, Castanotto, Daniella, Benimetskaya, Luba, Ørum, Henrik, Koch, Troels

“…For the past 15-20 years, the intracellular delivery and silencing activity of oligodeoxynucleotides have been essentially completely dependent on the use of a…”
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Silencing of gene expression by gymnotic delivery of antisense oligonucleotides by Soifer, Harris S, Koch, Troels, Lai, Johnathan, Hansen, Bo, Hoeg, Anja, Oerum, Henrik, Stein, C A

“…Antisense oligodeoxyribonucleotides have been used for decades to achieve sequence-specific silencing of gene expression. However, all early generation…”
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A Pharmacologic Target of G3139 in Melanoma Cells May Be the Mitochondrial VDAC by Lai, Johnathan C., Tan, Wenzhi, Benimetskaya, Luba, Miller, Paul, Colombini, Marco, Stein, C. A.

“…G3139, an 18-mer phosphorothioate antisense oligonucleotide targeted to the initiation codon region of the Bcl-2 mRNA, can induce caspase-dependent apoptosis…”
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Association of ABCB1 and FLT3 Polymorphisms with Toxicities and Survival in Asian Patients Receiving Sunitinib for Renal Cell Carcinoma by Chu, Ying-Hsia, Li, Huihua, Tan, Hui Shan, Koh, Valerie, Lai, Johnathan, Phyo, Wai Min, Choudhury, Yukti, Kanesvaran, Ravindran, Chau, Noan Minh, Toh, Chee Keong, Ng, Quan Sing, Tan, Puay Hoon, Chowbay, Balram, Tan, Min-Han

“…Sunitinib is a tyrosine kinase inhibitor used as first-line treatment for metastatic renal cell carcinoma (mRCC). Asian ethnicity has been previously…”
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Novel genetic aberrations in breast phyllodes tumours: comparison between prognostically distinct groups by Tan, Wai Jin, Lai, Johnathan C., Thike, Aye Aye, Lim, Jeffrey Chun Tatt, Tan, Sie Yong, Koh, Valerie Cui Yun, Lim, Tse Hui, Bay, Boon Huat, Tan, Min-Han, Tan, Puay Hoon

“…Phyllodes tumours of the breast are uncommon fibroepithelial neoplasms which pose management challenges due to difficulties in accurate prediction of clinical…”
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Phosphorothioate oligonucleotides reduce mitochondrial outer membrane permeability to ADP by Tan, Wenzhi, Lai, Johnathan C, Miller, Paul, Stein, C A, Colombini, Marco

“…G3139, an antisense Bcl-2 phosphorothioate oligodeoxyribonucleotide, induces apoptosis in melanoma and other cancer cells. This apoptosis happens before and in…”
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Antisense RNA Down-Regulation of bcl-2 Expression in DU145 Prostate Cancer Cells Does Not Diminish the Cytostatic Effects of G3139 (Oblimersen) by RAFFO, Anthony, LAI, Johnathan C, STEIN, C. A, MILLER, Paul, SCARINGE, Steven, KHVOROVA, Anastasia, BENIMETSKAYA, Luba

“…Purpose: Inhibition of the function of the bcl-2 protein has been postulated to sensitize cells to cytotoxic chemotherapy, and thus provides an attractive…”
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Phosphorothioate oligodeoxynucleotides and G3139 induce apoptosis in 518A2 melanoma cells by Lai, Johnathan C, Benimetskaya, Luba, Khvorova, Anastasia, Wu, Sijian, Hua, Emily, Miller, Paul, Stein, C A

“…In a previous study, we showed that G3139, an antisense phosphorothioate oligonucleotide that down-regulates the expression of Bcl-2 protein, did not cause…”
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Relative Bcl-2 Independence of Drug-Induced Cytotoxicity and Resistance in 518A2 Melanoma Cells by BENIMETSKAYA, Luba, LAI, Johnathan C, KHVOROVA, Anastasia, SIJIAN WU, HUA, Emily, MILLER, Paul, ZHANG, Li-Ming, STEIN, Cy A

“…Purpose: Inhibition of the function of Bcl-2 protein has been postulated to sensitize cells to cytotoxic chemotherapy. G3139 (Genasense) is a phosphorothioate…”
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Bcl-2 Protein in 518A2 Melanoma Cells In vivo and In vitro by BENIMETSKAYA, Luba, AYYANAR, Kanyalakshmi, MCMICKEN, Harilyn, YIN CHEN, STEIN, C. A, KORNBLUM, Noah, CASTANOTTO, Daniela, ROSSI, John, SIJIAN WU, LAI, Johnathan, BROWN, Bob D, POPOVA, Natalia, MILLER, Paul

“…Purpose: Bcl-2 is an apoptotic protein that is highly expressed in advanced melanoma. Several strategies have been employed to target the expression of this…”
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Changes in Gene Expression Induced by Phosphorothioate Oligodeoxynucleotides (Including G3139) in PC3 Prostate Carcinoma Cells Are Recapitulated at Least in Part by Treatment with Interferon-β and -γ by BENIMETSKAYA, Luba, WITTENBERGER, Timo, STEIN, C. A, HOFMANN, Hans-Peter, WELLER, Claudia, LAI, Johnathan C, MILLERS, Paul, GEKELER, Volker

“…Purpose: G3139 is an antisense bcl-2 phosphorothioate oligodeoxyribonucleotide that is currently being evaluated in Phase III clinical trials in several human…”
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Comparison of D-G3139 and Its Enantiomer L-G3139 in Melanoma Cells Demonstrates Minimal In Vitro but Dramatic In Vivo Chiral Dependency by Lai, Johnathan C, Brown, Bob D, Voskresenskiy, Anatoliy M, Vonhoff, Stefan, Klussman, Sven, Tan, Wenzhi, Colombini, Marco, Weeratna, Risini, Miller, Paul, Benimetskaya, Luba, Stein, Cy A

“…G3139 (Genasense), an 18mer phosphorothioate antisense oligonucleotide targeted to the initiation codon region of the Bcl-2 messenger RNA (mRNA), downregulates…”
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Protamine-Fragment Peptides Fused to an SV40 Nuclear Localization Signal Deliver Oligonucleotides That Produce Antisense Effects in Prostate and Bladder Carcinoma Cells by Benimetskaya, Luba, Guzzo-Pernell, Nancy, Liu, Su-Ting, Lai, Johnathan C. H, Miller, Paul, Stein, C. A

“…The development of antisense technology has focused on improving methods for oligonucleotide delivery into cells. In the present work, we describe a novel…”
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Induction of Apoptosis by G3139 in Melanoma Cells by BENIMETSKAYA, LUBA, LAI, JOHNATHAN C., KHVOROVA, ANASTASIA, WU, SIJIAN, MILLER, PAUL, STEIN, C A

“…G3139 is an 18mer phosphorothioate oligonucleotide targeted to the initiation codon region of the Bcl‐2 mRNA. Because of the ability of this antisense…”
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Single-Cell Measurements of Polyamidoamine Dendrimer Binding by Lai, Johnathan C., Yuan, Calin, Thomas, James L.

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Abstract PR14: Potent knock down of lncRNAs in vitro and in vivo with antisense LNA™ GapmeRs by Lai, Johnathan, Ozen, Asli, Mouritzen, Peter, Tolstrup, Niels, Frandsen, Niels Montano

“…Abstract Exiqon develops strategies for the optimal design of single stranded LNA™-enhanced antisense oligonucleotides (ASOs, also known as LNA™ GapmeRs) that…”
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1103-P: Glucose-Responsive Insulin: An Unprecedented Cleavable Linker Concept by MANNERSTEDT, KARIN, ENGHOLM, EBBE, MISHRA, NARENDRA KUMAR, LUNDH, MORTEN, BUCH-MÅNSON, NINA, FINK, LISBETH N., PEDERSEN, SØREN LJUNGBERG, PEDERSEN, PHILIP J., LE-HUU, PRISKA, LAI, JOHNATHAN, JENSEN, KNUD J., FOSGERAU, KELD

“…Achieving the optimal combination of multiple glucose measurements and insulin injections provides a complex daily situation for most insulin-dependent…”
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Profiling of microrna expression involved in iPSC generation, maintenance and differentiation using a high throughput, LNA™-enhanced qPCR method by Lai, Johnathan, Mei, Shirley, Ho, Mirabelle, Schlosser, Kenny, Stewart, Duncan, Mouritzen, Peter

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G3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner by Lai, Jonathan C, Benimetskaya, Luba, Santella, Regina M, Wang, Qiao, Miller, Paul S, Stein, C A

“…G3139 is an 18-mer phosphorothioate oligodeoxyribonucleotide, which is targeted to the initiation codon region of the bcl -2mRNA. Although treatment of PC3…”
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