Search Results - "Lai, Jean Luc"

High WT1 Expression After Induction Therapy Predicts High Risk of Relapse and Death in Pediatric Acute Myeloid Leukemia by LAPILLONNE, Hélène, RENNEVILLE, Aline, DEHEE, Axelle, BELLMAN, Francoise, ADAM, Mircéa, LABOPIN, Myriam, DOUAY, Luc, LEVERGER, Guy, PREUDHOMME, Claude, LANDMAN-PARKER, Judith, AUVRIGNON, Anne, FLAMANT, Cyril, BLAISE, Annick, PEROT, Christine, LAI, Jean-Luc, BALLERINI, Paola, MAZINGUE, Francoise, FASOLA, Sylvie

“…To determine whether minimal residual disease (MRD) measured by Wilms' tumor gene 1 (WT1) expression is a prognostic marker in pediatric acute myeloid leukemia…”
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Hyperdiploidy Is a Common Finding in Monoclonal Gammopathy of Undetermined Significance and Monosomy 13 Is Restricted to These Hyperdiploid Patients by BROUSSEAU, Maud, LELEU, Xavier, GERARD, Jérémie, GASTINNE, Thomas, GODON, Alban, GENEVIEVE, Franck, DIB, Mamoun, LAI, Jean-Luc, FACON, Thierry, ZANDECKI, Marc

“…Purpose: Two pathways, hyperdiploid and nonhyperdiploid, are proposed for progression to plasma cell neoplasia. Implication of monosomy 13 (Δ13) is unclear in…”
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Plasma cell growth fraction using Ki-67 antigen expression identifies a subgroup of multiple myeloma patients displaying short survival within the ISS stage I by Gastinne, Thomas, Leleu, Xavier, Duhamel, Alain, Moreau, Anne-Sophie, Franck, Genevieve, Andrieux, Joris, Lai, Jean-Luc, Coiteux, Valerie, Yakoub-Agha, Ibrahim, Bauters, Francis, Harousseau, Jean-Luc, Zandecki, Marc, Facon, Thierry

“…The current most powerful prognostic model in Multiple Myeloma (MM) combines beta‐2 microglobulin (b2m) with albumin, corresponding to the International…”
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Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation by Bousquet, Marina, Quelen, Cathy, Rosati, Roberto, Mansat-De Mas, Véronique, La Starza, Roberta, Bastard, Christian, Lippert, Eric, Talmant, Pascaline, Lafage-Pochitaloff, Marina, Leroux, Dominique, Gervais, Carine, Viguié, Franck, Lai, Jean-Luc, Terre, Christine, Beverlo, Berna, Sambani, Costantina, Hagemeijer, Anne, Marynen, Peter, Delsol, Georges, Dastugue, Nicole, Mecucci, Cristina, Brousset, Pierre

“…Most chromosomal translocations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) involve oncogenes that are either up-regulated or form part…”
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Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment by Roche-Lestienne, Catherine, Soenen-Cornu, Valerie, Grardel-Duflos, Nathalie, Laı̈, Jean-Luc, Philippe, Nathalie, Facon, Thierry, Fenaux, Pierre, Preudhomme, Claude

“…Targeting the tyrosine kinase activity ofBCR-ABL represents a very promising therapeutic strategy in chronic myeloid leukemia (CML). Despite strong efficacy of…”
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Chromosome 13 abnormalities identified by FISH analysis and serum β2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy by Facon, Thierry, Avet-Loiseau, Hervé, Guillerm, Gaëlle, Moreau, Philippe, Geneviève, Franck, Zandecki, Marc, Laı̈, Jean-Luc, Leleu, Xavier, Jouet, Jean-Pierre, Bauters, Francis, Harousseau, Jean-Luc, Bataille, Régis, Mary, Jean-Yves

“…A careful prognostic evaluation of patients referred for high-dose therapy (HDT) is warranted to identify those who maximally benefit from HDT as well as those…”
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RUNX1 DNA-binding mutations and RUNX1-PRDM16 cryptic fusions in BCR-ABL+ leukemias are frequently associated with secondary trisomy 21 and may contribute to clonal evolution and imatinib resistance by Roche-Lestienne, Catherine, Deluche, Lauréline, Corm, Sélim, Tigaud, Isabelle, Joha, Sami, Philippe, Nathalie, Geffroy, Sandrine, Laï, Jean-Luc, Nicolini, Franck-Emmanuel, Preudhomme, Claude

“…Acquired molecular abnormalities (mutations or chromosomal translocations) of the RUNX1 transcription factor gene are frequent in acute myeloblastic leukemias…”
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Patterns of genomic aberrations suggest that Burkitt lymphomas with complex karyotype are distinct from other aggressive B-cell lymphomas with MYC rearrangement by Havelange, Violaine, Ameye, Geneviève, Théate, Ivan, Callet-Bauchu, Evelyne, Mugneret, Francine, Michaux, Lucienne, Dastugue, Nicole, Penther, Dominique, Barin, Carole, Collonge-Rame, Marie-Agnès, Baranger, Laurence, Terré, Christine, Nadal, Nathalie, Lippert, Eric, Laï, Jean-Luc, Cabrol, Christine, Tigaud, Isabelle, Herens, Christian, Hagemeijer, Anne, Raphael, Martine, Libouton, Jeanne-Marie, Poirel, Hélène A.

“…We previously showed that complex karyotypes (CK) and chromosome 13q abnormalities have an adverse prognostic impact in childhood Burkitt lymphomas/leukemias…”
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A Mutation Conferring Resistance to Imatinib at the Time of Diagnosis of Chronic Myelogenous Leukemia by Roche-Lestienne, Catherine, Laï, Jean-Luc, Darré, Stéphane, Facon, Thierry, Preudhomme, Claude

“…To the Editor: Acquired resistance to imatinib mesylate caused by kinase-domain mutations is common in patients with chronic myelogenous leukemia who are…”
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Chronic myeloproliferative disorder with t(8;22)(p11;q11) can mime clonal cytogenetic evolution of authentic chronic myelogeneous leukemia by Richebourg, Steven, Theisen, Olivier, Plantier, Isabelle, Parry, Anne, Soenen-Cornu, Valérie, Lepelley, Pascale, Preudhomme, Claude, Renneville, Aline, Laï, Jean-Luc, Roche-Lestienne, Catherine

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Cryptic and partial deletions of PRDM16 and RUNX1 without t(1;21)(p36;q22) and/or RUNX1-PRDM16 fusion in a case of progressive chronic myeloid leukemia: A complex chromosomal rearrangement of underestimated frequency in disease progression? by Deluche, Lauréline, Joha, Sami, Corm, Sélim, Daudignon, Agnès, Geffroy, Sandrine, Quief, Sabine, Villenet, Céline, Kerckaert, Jean-Pierre, Laï, Jean-Luc, Preudhomme, Claude, Roche-Lestienne, Catherine

“…Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the presence in leukemic stem cells of the Philadelphia chromosome (Ph) and…”
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Genomic characterization of Imatinib resistance in CD34+ cell populations from chronic myeloid leukaemia patients by Joha, Sami, Dauphin, Véronique, Leprêtre, Frédéric, Corm, Sélim, Nicolini, Franck E, Roumier, Christophe, Nibourel, Olivier, Grardel, Nathalie, Maguer-Satta, Véronique, Idziorek, Thierry, Figeac, Martin, Laï, Jean-Luc, Quesnel, Bruno, Etienne, Gabriel, Guilhot, François, Lippert, Eric, Preudhomme, Claude, Roche-Lestienne, Catherine

“…Abstract To ascertain genomic alterations associated with Imatinib resistance in chronic myeloid leukaemia, we performed high resolution genomic analysis of…”
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M0 AML, clinical and biologic features of the disease, including AML1 gene mutations: a report of 59 cases by the Groupe Français d'Hématologie Cellulaire (GFHC) and the Groupe Français de Cytogénétique Hématologique (GFCH) by ROUMIER, Christophe, ECLACHE, Virginie, MAYNADIE, Marc, MUGNERET, Francine, BILHOU-NABERRA, Chrystele, VALENSI, Francoise, RADFORD, Isabelle, MOZZICONACCI, Marie Joëlle, ARNOULET, Christine, DUCHAYNE, Eliane, DASTUGUE, Nicole, CORNILLET, Pascale, IMBERT, Michelle, DALIPHARD, Sylvie, GARNACHE, Francine, BOUDJERRA, Najiba, JOUAULT, Helene, FENNETEAU, Odile, PEDRON, Béatrice, BERGER, Roland, FLANDRIN, Georges, FENAUX, Pierre, PREUDHOMME, Claude, DAVI, Frederic, MACLNTYRE, Elizabeth, GARAND, Richard, TALMANT, Pascaline, LEPELLEY, Pascale, LAI, Jean Luc, CASASNOVAS, Olivier

“…Mutations of the AML1 gene are frequent molecular abnormalities in minimally differentiated acute myeloblastic leukemia (M0 AML), a rare type of AML. In this…”
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Familial occurrence of thymoma and autoimmune diseases with the constitutional translocation t(14;20)(q24.1;p12.3) by Nicodème, Frédéric, Geffroy, Sandrine, Conti, Massimo, Delobel, Bruno, Soenen, Valérie, Grardel, Nathalie, Porte, Henri, Copin, Marie-Christine, Laï, Jean-Luc, Andrieux, Joris

“…Thymomas are low‐grade epithelial cancers of the thymus whose prevalence varies between 0.1/100,000 and 0.4/100,000. Familial occurrence of thymoma is very…”
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Irregular nuclear shape of bone marrow plasma cells defines a multiple myeloma subgroup related to hypodiploidy and to short survival by Leleu, Xavier, Genevieve, Franck, Guieze, Romain, Duhamel, Alain, Andrieux, Joris, Berthon, Celine, Godon, Alban, Prat-Lesaffre, Sophie, Depil, Stephane, Lai, Jean-Luc, Facon, Thierry, Zandecki, Marc

“…Morphological changes of plasma cells (PC) are common in multiple myeloma (MM). Loss of round or oval nuclear shape has been related to cell malignancy in…”
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Partial duplication of the MLL oncogene in patients with aggressive acute myeloid leukemia by Sambani, C, La Starza, R, Roumier, C, Crescenzi, B, Stavropoulou, C, Katsarou, O, Karafoulidou, A, Dhalle, JH, Lai, JL, Preudhomme, C, Martelli, MF, Mecucci, C

“…Laboratory of Health Physics & Environmental Hygiene, NCSR Demokritos, 15310 Athens, Greece. BACKGROUND AND OBJECTIVES: MLL translocations generate a fusion…”
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High incidence of cryptic translocations involving the Ig heavy chain gene in multiple myeloma, as shown by fluorescence in situ hybridization by Avet-Loiseau, Hervé, Brigaudeau, Christophe, Morineau, Nadine, Talmant, Pascaline, Laï, Jean-Luc, Daviet, Axelle, Li, Jian-Yong, Praloran, Vincent, Rapp, Marie-Josée, Harousseau, Jean-Luc, Facon, Thierry, Bataille, Régis

“…Cytogenetic studies have shown rearrangements of the Ig heavy chain (IGH) gene at 14q32 in 10–60% of patients with multiple myeloma (MM) or primary plasma cell…”
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Expression of HMGA2 in PB leukocytes and purified CD34+ cells from controls and patients with Myelofibrosis and myeloid metaplasia by Andrieux, Joris, Bilhou-Nabera, Chrystele, Lippert, Eric, Le Bousse-Kerdiles, Marie-Caroline, Dupriez, Brigitte, Grardel, Nathalie, Pierre-Louis, Olivier, Desterke, Christophe, Praloran, Vincent, Laï, Jean Luc, Demory, Jean-Loup

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Acute Myeloid Leukemia and Myelodysplastic Syndromes Following Essential Thrombocythemia Treated With Hydroxyurea: High Proportion of Cases With 17p Deletion by Sterkers, Yvon, Preudhomme, Claude, Laı̈, Jean-Luc, Demory, Jean-Loup, Caulier, Marie-Thérèse, Wattel, Eric, Bordessoule, Dominique, Bauters, Francis, Fenaux, Pierre

“…Treatment with alkylating agents or radiophosphorous (32P) has been shown to carry a certain leukemogenic risk in myeloproliferative disorders (MPDs),…”
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A report from the LALA-94 and LALA-SA groups on hypodiploidy with 30 to 39 chromosomes and near-triploidy: 2 possible expressions of a sole entity conferring poor prognosis in adult acute lymphoblastic leukemia (ALL) by Charrin, Christiane, Thomas, Xavier, Ffrench, Martine, Le, Quoc-Hung, Andrieux, Joris, Mozziconacci, Marie-Joelle, Laï, Jean-Luc, Bilhou-Nabera, Chrystele, Michaux, Lucienne, Bernheim, Alain, Bastard, Christian, Mossafa, Hossein, Perot, Christine, Maarek, Odile, Boucheix, Claude, Lheritier, Véronique, Delannoy, André, Fière, Denis, Dastugue, Nicole

“…To reveal the relationship between hypodiploidy with 30 to 39 chromosomes and near-triploidy in acute lymphoblastic leukemia (ALL), we studied 24 patients…”
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