Search Results - "Lai, G"

Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes by Drilon, Alexander, Hu, Zishuo I., Lai, Gillianne G. Y., Tan, Daniel S. W.

“…Key Points Activating alterations of the RET kinase are therapeutically actionable oncogenic drivers across a variety of cancers; in-frame RET rearrangements…”
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Pan-cancer analyses of the associations between 109 pre-existing conditions and cancer treatment patterns across 19 adult cancers by Chang, Wai Hoong, Lai, Alvina G.

“…Comorbidities present considerable challenges to cancer treatment and care. However, little is known about the effect of comorbidity on cancer treatment…”
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An Integrated Current–Wave–Sediment Model for Coastal and Estuary Simulation by Lai, Yong G.

“…An integrated current–wave–sediment model is developed for coastal and estuary applications. The new model aims to improve the existing ones in both the…”
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Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies by Chang, Wai Hoong, Lai, Alvina G

“…The circadian clock governs a large variety of fundamentally important physiological processes in all three domains of life. Consequently, asynchrony in…”
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Graphene oxide incorporated thin film nanocomposite nanofiltration membrane for enhanced salt removal performance by Lai, G.S., Lau, W.J., Goh, P.S., Ismail, A.F., Yusof, N., Tan, Y.H.

“…One of the most critical issues encountered by thin film composite (TFC) nanofiltration (NF) membrane in water softening is the trade-off between water flux…”
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An integrative pan-cancer investigation reveals common genetic and transcriptional alterations of AMPK pathway genes as important predictors of clinical outcomes across major cancer types by Chang, Wai Hoong, Lai, Alvina G

“…The AMP-activated protein kinase (AMPK) is an evolutionarily conserved regulator of cellular energy homeostasis. As a nexus for transducing metabolic signals,…”
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Estimated impact of the COVID-19 pandemic on cancer services and excess 1-year mortality in people with cancer and multimorbidity: near real-time data on cancer care, cancer deaths and a population-based cohort study by Lai, Alvina G, Pasea, Laura, Banerjee, Amitava, Hall, Geoff, Denaxas, Spiros, Chang, Wai Hoong, Katsoulis, Michail, Williams, Bryan, Pillay, Deenan, Noursadeghi, Mahdad, Linch, David, Hughes, Derralynn, Forster, Martin D, Turnbull, Clare, Fitzpatrick, Natalie K, Boyd, Kathryn, Foster, Graham R, Enver, Tariq, Nafilyan, Vahe, Humberstone, Ben, Neal, Richard D, Cooper, Matt, Jones, Monica, Pritchard-Jones, Kathy, Sullivan, Richard, Davie, Charlie, Lawler, Mark, Hemingway, Harry

“…ObjectivesTo estimate the impact of the COVID-19 pandemic on cancer care services and overall (direct and indirect) excess deaths in people with…”
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An immunoevasive strategy through clinically-relevant pan-cancer genomic and transcriptomic alterations of JAK-STAT signaling components by Chang, Wai Hoong, Lai, Alvina G

“…Since its discovery almost three decades ago, the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway has paved the road for…”
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Comparative genomic analysis of innate immunity reveals novel and conserved components in crustacean food crop species by Lai, Alvina G, Aboobaker, A Aziz

“…Growing global demands for crustacean food crop species have driven large investments in aquaculture research worldwide. However, large-scale production is…”
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Pan-cancer prognostic genetic mutations and clinicopathological factors associated with survival outcomes: a systematic review by Gammall, Jurgita, Lai, Alvina G.

“…Cancer is a leading cause of death, accounting for almost 10 million deaths annually worldwide. Personalised therapies harnessing genetic and clinical…”
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Local modulation of double optomechanically induced transparency and amplification by Yang, Q, Hou, B P, Lai, D G

“…We consider the probe absorption properties in a mechanically coupled optomechanical system in which the two coupled nanomechanical oscillators are driven by…”
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Interplay between circadian clock and viral infection by Zhuang, Xiaodong, Rambhatla, Srinivasa Bhargav, Lai, Alvina G., McKeating, Jane A.

“…The circadian clock underpins most physiological conditions and provides a temporal dimension to our understanding of body and tissue homeostasis. Disruptions…”
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A Two-Dimensional Depth-Averaged Sediment Transport Mobile-Bed Model with Polygonal Meshes by Lai, Yong G.

“…A polygonal-mesh based numerical method is developed to simulate sediment transport in mobile-bed streams with free surfaces. The flow and sediment transport…”
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A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers by Chang, Wai Hoong, Forde, Donall, Lai, Alvina G

“…Despite much progress in cancer research, its incidence and mortality continue to rise. A robust biomarker that would predict tumor behavior is highly…”
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Mixed evolutionary origins of endogenous biomass-depolymerizing enzymes in animals by Chang, Wai Hoong, Lai, Alvina G

“…Animals are thought to achieve lignocellulose digestion via symbiotic associations with gut microbes; this view leads to significant focus on bacteria and…”
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Virtual Creature Morphology ‐ A Review by Lai, G., Leymarie, F.F., Latham, W., Arita, T., Suzuki, R.

“…We present a review of methods for procedurally generating the morphology of virtual creatures. We include a range of methods, with the main groups being from…”
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H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma by Joshi, Jaya Julie, Coffey, Heather, Corcoran, Erik, Tsai, Jennifer, Huang, Chia-Ling, Ichikawa, Kana, Prajapati, Sudeep, Hao, Ming-Hong, Bailey, Suzanna, Wu, Jeremy, Rimkunas, Victoria, Karr, Craig, Subramanian, Vanitha, Kumar, Pavan, MacKenzie, Crystal, Hurley, Raelene, Satoh, Takashi, Yu, Kun, Park, Eunice, Rioux, Nathalie, Kim, Amy, Lai, Weidong G, Yu, Lihua, Zhu, Ping, Buonamici, Silvia, Larsen, Nicholas, Fekkes, Peter, Wang, John, Warmuth, Markus, Reynolds, Dominic J, Smith, Peter G, Selvaraj, Anand

“…Activation of the fibroblast growth factor receptor FGFR4 by FGF19 drives hepatocellular carcinoma (HCC), a disease with few, if any, effective treatment…”
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Cumulative burden of 144 conditions, critical care hospitalisation and premature mortality across 26 adult cancers by Chang, Wai Hoong, Neal, Richard D., Forster, Martin D., Lai, Alvina G.

“…A comprehensive evaluation of the total burden of morbidity endured by cancer survivors remains unavailable. This study quantified the burden of 144 health…”
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Flow Characteristics at a River Diversion Juncture and Implications for Juvenile Salmon Entrainment by Lai, Yong G.

“…Flow structures at a river diversion juncture are complex and have been studied extensively. Their impact on the juvenile salmon entrainment into the side…”
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A Three-Dimensional Atlas of Human Dermal Leukocytes, Lymphatics, and Blood Vessels by Wang, Xiao-Nong, McGovern, Naomi, Gunawan, Merry, Richardson, Connor, Windebank, Martin, Siah, Tee-Wei, Lim, Hwee-Ying, Fink, Katja, Yao Li, Jackson L., Ng, Lai G., Ginhoux, Florent, Angeli, Veronique, Collin, Matthew, Haniffa, Muzlifah

“…Dendritic cells (DCs), macrophages (Mφ), and T cells are major components of the skin immune system, but their interstitial spatial organization is poorly…”
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