Effect of Real-Time Computer-Aided Polyp Detection System (ENDO-AID) on Adenoma Detection in Endoscopists-in-Training: A Randomized Trial

Effect of Real-Time Computer-Aided Polyp Detection System (ENDO-AID) on Adenoma Detection in Endoscopists-in-Training: A Randomized Trial

The effect of computer-aided polyp detection (CADe) on adenoma detection rate (ADR) among endoscopists-in-training remains unknown. We performed a single-blind, parallel-group, randomized controlled trial in Hong Kong between April 2021 and July 2022 (NCT04838951). Eligible subjects undergoing scree...

Full description

Saved in:
Bibliographic Details
Published in:Clinical gastroenterology and hepatology Vol. 22; no. 3; pp. 630 - 641.e4
Main Authors: Lau, Louis H.S., Ho, Jacky C.L., Lai, Jimmy C.T., Ho, Agnes H.Y., Wu, Claudia W.K., Lo, Vincent W.H., Lai, Carol M.S., Scheppach, Markus W., Sia, Felix, Ho, Kyle H.K., Xiao, Xiang, Yip, Terry C.F., Lam, Thomas Y.T., Kwok, Hanson Y.H., Chan, Heyson C.H., Lui, Rashid N., Chan, Ting-Ting, Wong, Marc T.L., Ho, Man-Fung, Ko, Rachel C.W., Hon, Sok-Fei, Chu, Simon, Futaba, Koari, Ng, Simon S.M., Yip, Hon-Chi, Tang, Raymond S.Y., Wong, Vincent W.S., Chan, Francis K.L., Chiu, Philip W.Y.
Format: Journal Article
Language:English
Published: Elsevier Inc 01-03-2024
Subjects:
Adenoma Detection Rate
ADR
CADe
Colonoscopy
Computer-Aided Polyp Detection
Training
Training
CADe
RR
Adenoma Detection Rate
Computer-Aided Polyp Detection
APC
CRC
Colonoscopy
CI
SSL
ADR
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of computer-aided polyp detection (CADe) on adenoma detection rate (ADR) among endoscopists-in-training remains unknown. We performed a single-blind, parallel-group, randomized controlled trial in Hong Kong between April 2021 and July 2022 (NCT04838951). Eligible subjects undergoing screening/surveillance/diagnostic colonoscopies were randomized 1:1 to receive colonoscopies with CADe (ENDO-AID[OIP-1]) or not (control) during withdrawal. Procedures were performed by endoscopists-in-training with <500 procedures and <3 years’ experience. Randomization was stratified by patient age, sex, and endoscopist experience (beginner vs intermediate level, <200 vs 200–500 procedures). Image enhancement and distal attachment devices were disallowed. Subjects with incomplete colonoscopies or inadequate bowel preparation were excluded. Treatment allocation was blinded to outcome assessors. The primary outcome was ADR. Secondary outcomes were ADR for different adenoma sizes and locations, mean number of adenomas, and non-neoplastic resection rate. A total of 386 and 380 subjects were randomized to CADe and control groups, respectively. The overall ADR was significantly higher in the CADe group than in the control group (57.5% vs 44.5%; adjusted relative risk, 1.41; 95% CI, 1.17–1.72; P < .001). The ADRs for <5 mm (40.4% vs 25.0%) and 5- to 10-mm adenomas (36.8% vs 29.2%) were higher in the CADe group. The ADRs were higher in the CADe group in both the right colon (42.0% vs 30.8%) and left colon (34.5% vs 27.6%), but there was no significant difference in advanced ADR. The ADRs were higher in the CADe group among beginner (60.0% vs 41.9%) and intermediate-level (56.5% vs 45.5%) endoscopists. Mean number of adenomas (1.48 vs 0.86) and non-neoplastic resection rate (52.1% vs 35.0%) were higher in the CADe group. Among endoscopists-in-training, the use of CADe during colonoscopies was associated with increased overall ADR. (ClinicalTrials.gov, Number: NCT04838951). [Display omitted]
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
ISSN:1542-3565
1542-7714
DOI:10.1016/j.cgh.2023.10.019