Search Results - "Lai, Benjamin F. L"

Design of Long Circulating Nontoxic Dendritic Polymers for the Removal of Iron in Vivo by Imran ul-haq, Muhammad, Hamilton, Jasmine L, Lai, Benjamin F. L, Shenoi, Rajesh A, Horte, Sonja, Constantinescu, Iren, Leitch, Heather A, Kizhakkedathu, Jayachandran N

“…Patients requiring chronic red blood cell (RBC) transfusions for inherited or acquired anemias are at risk of developing transfusional iron overload, which may…”
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Modulation of Complement Activation and Amplification on Nanoparticle Surfaces by Glycopolymer Conformation and Chemistry by Yu, Kai, Lai, Benjamin F. L, Foley, Jonathan H, Krisinger, Michael J, Conway, Edward M, Kizhakkedathu, Jayachandran N

“…The complement system plays an integral part of a host’s innate immunity, and its activation is highly dependent on the chemistry and structure of a “foreign”…”
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Hyperbranched Glycopolymers for Blood Biocompatibility by Ahmed, Marya, Lai, Benjamin F. L, Kizhakkedathu, Jayachandran N, Narain, Ravin

“…Carbohydrate-based drug and gene delivery carriers are becoming extremely popular for in vitro and in vivo applications. These carriers are found to be…”
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Branched Multifunctional Polyether Polyketals: Variation of Ketal Group Structure Enables Unprecedented Control over Polymer Degradation in Solution and within Cells by Shenoi, Rajesh A, Narayanannair, Jayaprakash K, Hamilton, Jasmine L, Lai, Benjamin F. L, Horte, Sonja, Kainthan, Rajesh K, Varghese, Jos P, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Kizhakkedathu, Jayachandran N

“…Multifunctional biocompatible and biodegradable nanomaterials incorporating specific degradable linkages that respond to various stimuli and with defined…”
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Synthesis, Characterization, and Biocompatibility of Biodegradable Hyperbranched Polyglycerols from Acid-Cleavable Ketal Group Functionalized Initiators by Shenoi, Rajesh A, Lai, Benjamin F. L, Kizhakkedathu, Jayachandran N

“…Herein we report the synthesis of biodegradable hyperbranched polyglycerols (BHPGs) having acid-cleavable core structure by anionic ring-opening multibranching…”
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Hemocompatibility of Degrading Polymeric Biomaterials: Degradable Polar Hydrophobic Ionic Polyurethane versus Poly(lactic-co-glycolic) Acid by Brockman, Kathryne S, Lai, Benjamin F. L, Kizhakkedathu, Jayachandran N, Santerre, J. Paul

“…The use of degradable polymers in vascular tissue regeneration has sparked the need to characterize polymer biocompatibility during degradation. While tissue…”
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Conjugation of Aurein 2.2 to HPG Yields an Antimicrobial with Better Properties by Kumar, Prashant, Shenoi, Rajesh A, Lai, Benjamin F. L, Nguyen, Michael, Kizhakkedathu, Jayachandran N, Straus, Suzana K

“…Aurein 2.2 is an antimicrobial peptide (AMP) whose mechanism of action is quite well-understood and that has good activity against Gram-positive bacteria. It…”
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Alteration of blood clotting and lung damage by protamine are avoided using the heparin and polyphosphate inhibitor UHRA by Kalathottukaren, Manu Thomas, Abraham, Libin, Kapopara, Piyushkumar R., Lai, Benjamin F.L., Shenoi, Rajesh A., Rosell, Federico I., Conway, Edward M., Pryzdial, Edward L.G., Morrissey, James H., Haynes, Charles A., Kizhakkedathu, Jayachandran N.

“…Anticoagulant therapy–associated bleeding and pathological thrombosis pose serious risks to hospitalized patients. Both complications could be mitigated by…”
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Affinity-based design of a synthetic universal reversal agent for heparin anticoagulants by Shenoi, Rajesh A, Kalathottukaren, Manu Thomas, Travers, Richard J, Lai, Benjamin F L, Creagh, A Louise, Lange, Dirk, Yu, Kai, Weinhart, Marie, Chew, Ben H, Du, Caigan, Brooks, Donald E, Carter, Cedric J, Morrissey, James H, Haynes, Charles A, Kizhakkedathu, Jayachandran N

“…Heparin-based anticoagulant drugs have been widely used for the prevention of blood clotting during surgical procedures and for the treatment of thromboembolic…”
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In vivo efficacy, toxicity and biodistribution of ultra-long circulating desferrioxamine based polymeric iron chelator by Hamilton, Jasmine L, Imran ul-haq, Muhammad, Abbina, Srinivas, Kalathottukaren, Manu Thomas, Lai, Benjamin F.L, Hatef, Azadeh, Unniappan, Suraj, Kizhakkedathu, Jayachandran N

“…Abstract Desferrioxamine (DFO) is currently in clinical use to remove iron from transfusion-dependent patients with β-thalassemia major, sickle-cell anemia and…”
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Interaction of blood components with cathelicidins and their modified versions by Yu, Kai, Lai, Benjamin F.L, Gani, Jurnorain, Mikut, Ralf, Hilpert, Kai, Kizhakkedathu, Jayachandran N

“…Abstract Cationic antimicrobial peptides (cAMPs) serve as effective components of the innate host defense against microbial infections. cAMPs often show…”
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Blood Components Interactions to Ionic and Nonionic Glyconanogels by Narain, Ravin, Wang, Yinan, Ahmed, Marya, Lai, Benjamin F.L, Kizhakkedathu, Jayachandran N

“…Nanogels are prominent examples of “smart” nanomaterials, which are designed to incorporate biologically relevant (macro)­molecules for systemic delivery…”
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Engineering microenvironment for human cardiac tissue assembly in heart-on-a-chip platform by Zhao, Yimu, Rafatian, Naimeh, Wang, Erika Y., Feric, Nicole T., Lai, Benjamin F.L., Knee-Walden, Ericka J., Backx, Peter H., Radisic, Milica

“…Organ-on-a-chip systems have the potential to revolutionize drug screening and disease modeling through the use of human stem cell-derived cardiomyocytes. The…”
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The induction of thrombus generation on nanostructured neutral polymer brush surfaces by Lai, Benjamin F.L, Creagh, A. Louise, Janzen, Johan, Haynes, Charles A, Brooks, Donald E, Kizhakkedathu, Jayachandran N

“…Abstract Surface induced thrombus generation is a major clinical concern associated with vascular medical devices and implants. Here, we show that high graft…”
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Towards chamber specific heart-on-a-chip for drug testing applications by Zhao, Yimu, Rafatian, Naimeh, Wang, Erika Yan, Wu, Qinghua, Lai, Benjamin F.L., Lu, Rick Xingze, Savoji, Houman, Radisic, Milica

“…Modeling of human organs has long been a task for scientists in order to lower the costs of therapeutic development and understand the pathological onset of…”
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Bioreducible hyperbranched polyglycerols with disulfide linkages: Synthesis and biocompatibility evaluation by Shenoi, Rajesh A, Chafeeva, Irina, Lai, Benjamin F. L, Horte, Sonja, Kizhakkedathu, Jayachandran N

“…In this article, we describe the development of multifunctional, water‐soluble hyperbranched polyglycerols containing redox‐sensitive disulfide linkages as a…”
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Hybrid Polyglycerols with Long Blood Circulation: Synthesis, Biocompatibility, and Biodistribution by Imran ul-haq, Muhammad, Lai, Benjamin F. L., Kizhakkedathu, Jayachandran N.

“…Multifunctional polymers with defined structure and biocompatibility are critical to the development of drug delivery systems and bioconjugates. In this…”
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Carbohydrate Structure Dependent Hemocompatibility of Biomimetic Functional Polymer Brushes on Surfaces by Yu, Kai, Lai, Benjamin F. L., Kizhakkedathu, Jayachandran N.

“…Glycocalyx mimicking glycopolymer brushes presenting mannose, galactose and glucose residues in the pyranose form, similar to those present on cell surfaces,…”
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Inhibitory Effect of Hydrophilic Polymer Brushes on Surface-Induced Platelet Activation and Adhesion by Zou, Yuquan, Lai, Benjamin F.L., Kizhakkedathu, Jayachandran N., Brooks, Donald E.

“…Poly(N,N‐dimethylacrylamide) (PDMA) brushes are successfully grown from unplasticized poly(vinyl chloride) (uPVC) by well‐controlled surface‐initiated atom…”
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Multilayered coating on titanium for controlled release of antimicrobial peptides for the prevention of implant-associated infections by Kazemzadeh-Narbat, Mehdi, Lai, Benjamin F.L, Ding, Chuanfan, Kizhakkedathu, Jayachandran N, Hancock, Robert E.W, Wang, Rizhi

“…Abstract Prevention of bacterial colonization and formation of a bacterial biofilm on implant surfaces has been a challenge in orthopaedic surgery. The…”
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