Search Results - "Lai, Baochang"

Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages by Tian, Ying, Yang, Chunmiao, Yao, Qinyu, Qian, Lei, Liu, Jia, Xie, Xinya, Ma, Wen, Nie, Xin, Lai, Baochang, Xiao, Lei, Wang, Nanping

“…Procyanidins, a subclass of flavonoids found in commonly consumed foods, possess potential anti-inflammatory activity. Manipulation of M1/M2 macrophage…”
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Stachydrine protects eNOS uncoupling and ameliorates endothelial dysfunction induced by homocysteine by Xie, Xinya, Zhang, Zihui, Wang, Xinfeng, Luo, Zhenyu, Lai, Baochang, Xiao, Lei, Wang, Nanping

“…Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular diseases (CVDs). Stachydrine (STA) is an active component in Chinese motherwort…”
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Xenobiotic Pregnane X Receptor (PXR) Regulates Innate Immunity via Activation of NLRP3 Inflammasome in Vascular Endothelial Cells by Wang, Shaolan, Lei, Ting, Zhang, Kang, Zhao, Wenxiang, Fang, Li, Lai, Baochang, Han, Jie, Xiao, Lei, Wang, Nanping

“…Pregnane X receptor (PXR) is a member of nuclear receptor superfamily and responsible for the detoxification of xenobiotics. Our previously study demonstrated…”
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Yes-Associated Protein Contributes to the Development of Human Cutaneous Squamous Cell Carcinoma via Activation of RAS by Jia, Jinjing, Li, Changji, Luo, Suju, Liu-Smith, Feng, Yang, Jiao, Wang, Xin, Wang, Nanping, Lai, Baochang, Lei, Ting, Wang, Qiongyu, Xiao, Shengxiang, Shao, Yongping, Zheng, Yan

“…Cutaneous squamous cell carcinoma (cSCC) is one of the most common skin malignant tumors with an increasing incidence. Studies have shown that Yes-associated…”
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Procyanidin B2 ameliorates endothelial dysfunction induced by nicotine via the induction of tetrahydrobiopterin synthesis by Liu, Jia, Du, Xiong, Yao, Qinyu, Jiang, Tingting, Cui, Qi, Xie, Xinya, Zhao, Ziwei, Lai, Baochang, Wang, Nanping, Xiao, Lei

“…[Display omitted] •Nicotine decreases the expression of DHFR and GCH1 to inhibit BH4 and NO production.•PCB2 prevents nicotine-induced DHFR and GCH1 loss.•PCB2…”
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CCN1/Integrin α5β1 Instigates Free Fatty Acid-Induced Hepatocyte Lipid Accumulation and Pyroptosis through NLRP3 Inflammasome Activation by Yao, Qinyu, Liu, Jia, Cui, Qi, Jiang, Tingting, Xie, Xinya, Du, Xiong, Zhao, Ziwei, Lai, Baochang, Xiao, Lei, Wang, Nanping

“…Hyperlipidemia with high blood levels of free fatty acids (FFA) is the leading cause of non-alcoholic steatohepatitis. CCN1 is a secreted matricellular protein…”
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Procyanidin B2 Attenuates Nicotine-Induced Hepatocyte Pyroptosis through a PPARγ-Dependent Mechanism by Liu, Jia, Yao, Qinyu, Xie, Xinya, Cui, Qi, Jiang, Tingting, Zhao, Ziwei, Du, Xiong, Lai, Baochang, Xiao, Lei, Wang, Nanping

“…Procyanidin B2 (PCB2), a natural flavonoid, has been demonstrated to exert anti-oxidation and anti-inflammatory effects on hepatic diseases. Increasing…”
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Homocysteine upregulates hepcidin expression through BMP6/SMAD signaling pathway in hepatocytes by Luo, Xiaoqin, Luo, Zhenyu, Zhang, Zihui, Yang, Haixia, Lai, Baochang, Yao, Qinyu, Xiao, Lei, Wang, Nanping

“…Subjects with severe hyperhomocysteinemia have hypoferric anemia and excessive iron deposition in the liver. Hepcidin, the central regulator of iron…”
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Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development by Liu, Huahua, Zhou, Rui, Li, Shanshan, Dong, Jinling, Fang, Yuan, Luo, Yuru, Su, Hongyu, Lai, Baochang, Liang, Lingli, Zhang, Donghong, Zhang, Yanmin, Shyy, John Y-J., Zhou, Bin, Yuan, Zuyi, Wang, Yidong

“…Epigenetic regulation of heart development remains incompletely understood. Here we show that LSD1, a histone demethylase, plays a crucial role in regulating…”
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Induction of oxidative stress and DNA damage in cervix in acute treatment with benzo[a]pyrene by Gao, Meili, Li, Yongfei, Long, Jiangang, Shah, Walayat, Fu, Ling, Lai, Baochang, Wang, Yili

“…Benzo[a]pyrene [B(a)P] is one of the most prevalent environmental carcinogens and genotoxic agents. However, the mechanisms of B(a)P-induced oxidative damage…”
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Nuciferine ameliorates hepatic steatosis in high‐fat diet/streptozocin‐induced diabetic mice through a PPARα/PPARγ coactivator‐1α pathway by Zhang, Chao, Deng, Jianjun, Liu, Dan, Tuo, Xingxia, Xiao, Lei, Lai, Baochang, Yao, Qinyu, Liu, Jia, Yang, Haixia, Wang, Nanping

“…Background and Purpose Nuciferine, an alkaloid found in Nelumbo nucifera leaves, alleviates dyslipidemia in vivo. However, whether it improves liver injury in…”
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PFKFB3-mediated glycolysis in hepatic stellate cells promotes liver regeneration by Cao, Yapeng, Wang, Siyu, Zhang, Min, Lai, Baochang, Liang, Yanni

“…Hepatic stellate cells (HSCs) perform a significant function in liver regeneration (LR) by becoming active. We propose to investigate if activated HSCs enhance…”
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Peroxisome proliferator–activated receptor γ (PPARγ) induces the gene expression of integrin αVβ5 to promote macrophage M2 polarization by Yao, Qinyu, Liu, Jia, Zhang, Zihui, Li, Fan, Zhang, Chao, Lai, Baochang, Xiao, Lei, Wang, Nanping

“…Peroxisome proliferator–activated receptor γ (PPARγ) is a member of the nuclear receptor superfamily and polarizes the macrophages into an anti-inflammatory M2…”
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Statins Attenuate Activation of the NLRP3 Inflammasome by Oxidized LDL or TNF α in Vascular Endothelial Cells through a PXR-Dependent Mechanism by Wang, Shaolan, Xie, Xinya, Lei, Ting, Zhang, Kang, Lai, Baochang, Zhang, Zihui, Guan, Youfei, Mao, Guangmei, Xiao, Lei, Wang, Nanping

“…Excessive activation of the NLRP3 inflammasome is implicated in cardiovascular diseases. Statins exert an anti-inflammatory effect independent of their…”
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A pan-cancer analysis confirms PTPN11’s potential as a prognostic and immunological biomarker by Cao, Yapeng, Duan, Haixia, Su, Ailing, Xu, Liran, Lai, Baochang

“…Protein tyrosine phosphatase, non-receptor type 11 (PTPN11) is a multifunctional tyrosine phosphatase and has a significant part in many types of tumors. As of…”
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PPARγ induces NEDD4 gene expression to promote autophagy and insulin action by Liu, Jia, Yao, Qinyu, Xiao, Lei, Ma, Wen, Li, Fan, Lai, Baochang, Wang, Nanping

“…The E3 ubiquitin ligase neural precursor cell‐expressed developmentally down‐regulated protein 4 (NEDD4) plays a crucial role in governing a number of…”
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Endothelial MicroRNA-483-3p Is Hypertension-Protective by Shang, Fenqing, Guo, Xuan, Chen, Yueer, Wang, Chen, Gao, Jie, Wen, Ergang, Lai, Baochang, Bai, Liang

“…Hypertension is a high-risk factor for developing coronary heart disease and stroke. Endothelial dysfunction and arterial remodeling can lead to increased…”
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Atheroprone flow enhances the endothelial-to-mesenchymal transition by Lai, Baochang, Li, Zhao, He, Ming, Wang, Yili, Chen, Lili, Zhang, Jiao, Yang, Yan, Shyy, John Y-J

“…The endothelial-to-mesenchymal transition (EndoMT) is a cellular process featuring decreased expression of endothelial marker genes but increased expression of…”
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221S-1a inhibits endothelial proliferation in pathological angiogenesis through ERK/c-Myc signaling by Yao, Xinye, Xue, Yanbo, Ma, Qiang, Bai, Yajun, Jia, Pu, Zhang, Yiman, Lai, Baochang, He, Shuting, Ma, Qiong, Zhang, Junbo, Tian, Hongyan, Yin, Qian, Zheng, Xiaohui, Zheng, Xiaopu

“…Pathological angiogenesis plays a major role in many disease processes, including cancer and diabetic retinopathy. Antiangiogenic therapy is a potential…”
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Free fatty acids stabilize integrin β1via S-nitrosylation to promote monocyte–endothelial adhesion by Yao, Qinyu, Cui, Qi, Liu, Jia, Xie, Xinya, Jiang, Tingting, Wang, Haodong, Zhao, Ziwei, Zhao, Wenfei, Du, Xiong, Lai, Baochang, Xiao, Lei, Wang, Nanping

“…Hyperlipidemia characterized by high blood levels of free fatty acids (FFAs) is important for the progression of inflammatory cardiovascular diseases. Integrin…”
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