Search Results - "Lai, Alon"

Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model by Lai, Alon, Iliff, Denise, Zaheer, Kashaf, Gansau, Jennifer, Laudier, Damien M, Zachariou, Venetia, Iatridis, James C

“…Chronic painful intervertebral disc (IVD) degeneration (i.e., discogenic pain) is a major source of global disability needing improved knowledge on…”
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Leptin signaling and the intervertebral disc: Sex dependent effects of leptin receptor deficiency and Western diet on the spine in a type 2 diabetes mouse model by Natelson, Devorah M, Lai, Alon, Krishnamoorthy, Divya, Hoy, Robert C, Iatridis, James C, Illien-Jünger, Svenja

“…Type 2 diabetes and obesity are associated with back pain in juveniles and adults and are implicated in intervertebral disc (IVD) degeneration. Hypercaloric…”
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Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration by Lai, Alon, Iliff, Denise, Zaheer, Kashaf, Wang, Dalin, Gansau, Jennifer, Laudier, Damien M, Zachariou, Venetia, Iatridis, James C

“…Intervertebral disc (IVD) degeneration with Modic-like changes is strongly associated with pain. Lack of effective disease-modifying treatments for IVDs with…”
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Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses by Schuchman, Edward H, Ge, Yi, Lai, Alon, Borisov, Yury, Faillace, Meghan, Eliyahu, Efrat, He, Xingxuan, Iatridis, James, Vlassara, Helen, Striker, Gary, Simonaro, Calogera M

“…Pentosan polysulfate (PPS) is an FDA-approved, oral medication with anti-inflammatory and pro-chondrogenic properties. We have previously shown that animal…”
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Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model by Lai, Alon, Ho, Lap, Evashwick-Rogler, Thomas W, Watanabe, Hironobu, Salandra, Jonathan, Winkelstein, Beth A, Laudier, Damien, Hecht, Andrew C, Pasinetti, Giulio M, Iatridis, James C

“…Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic…”
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Development of a standardized histopathology scoring system for intervertebral disc degeneration in rat models: An initiative of the ORS spine section by Lai, Alon, Gansau, Jennifer, Gullbrand, Sarah E., Crowley, James, Cunha, Carla, Dudli, Stefan, Engiles, Julie B., Fusellier, Marion, Goncalves, Raquel M., Nakashima, Daisuke, Okewunmi, Jeffrey, Pelletier, Matthew, Presciutti, Steven M., Schol, Jordy, Takeoka, Yoshiki, Yang, Sidong, Yurube, Takashi, Zhang, Yejia, Iatridis, James C.

“…Background Rats are a widely accepted preclinical model for evaluating intervertebral disc (IVD) degeneration and regeneration. IVD morphology is commonly…”
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Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo by Lai, Alon, PhD, Moon, Andrew, BSc, Purmessur, Devina, PhD, Skovrlj, Branko, MD, Laudier, Damien M., BSc, Winkelstein, Beth A., PhD, Cho, Samuel K., MD, Hecht, Andrew C., MD, Iatridis, James C., PhD

“…Abstract Background Context Painfulintervertebral disc degeneration is extremely common and costly. Effective treatments are lacking because the nature of…”
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Dose responsive effects of subcutaneous pentosan polysulfate injection in mucopolysaccharidosis type VI rats and comparison to oral treatment by Frohbergh, Michael, Ge, Yi, Meng, Fanli, Karabul, Nesrin, Solyom, Alexander, Lai, Alon, Iatridis, James, Schuchman, Edward H, Simonaro, Calogera M

“…We previously demonstrated the benefits of daily, oral pentosan polysulfate (PPS) treatment in a rat model of mucopolysaccharidosis (MPS) type VI. Herein we…”
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Correction: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model by Lai, Alon, Ho, Lap, Evashwick-Rogler, Thomas W, Watanabe, Hironobu, Salandra, Jonathan, Winkelstein, Beth A, Laudier, Damien, Hecht, Andrew C, Pasinetti, Giulio M, Iatridis, James C

“…[This corrects the article DOI: 10.1371/journal.pone.0223435.]…”
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Effects of Torsion on Intervertebral Disc Gene Expression and Biomechanics, Using a Rat Tail Model by BARBIR, Ana, GODBURN, Karolyn E, MICHALEK, Arthur J, LAI, Alon, MONSEY, Robert D, LATRIDIS, James C

“…In vitro and in vivo rat tail model to assess effects of torsion on intervertebral disc biomechanics and gene expression. Investigate effects of torsion on…”
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Inhibiting tumor necrosis factor‐alpha at time of induced intervertebral disc injury limits long‐term pain and degeneration in a rat model by Evashwick‐Rogler, Thomas W., Lai, Alon, Watanabe, Hironobu, Salandra, Jonathan M., Winkelstein, Beth A., Cho, Samuel K., Hecht, Andrew C., Iatridis, James C.

“…To determine the role of tumor necrosis factor‐alpha (TNFα) on initiating painful intervertebral disc (IVD) degeneration, rat lumbar IVDs were punctured and…”
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Development of a standardized histopathology scoring system for intervertebral disc degeneration and regeneration in rabbit models‐An initiative of the ORSspine section by Gullbrand, Sarah E., Ashinsky, Beth G., Lai, Alon, Gansau, Jennifer, Crowley, James, Cunha, Carla, Engiles, Julie B., Fusellier, Marion, Muehleman, Carol, Pelletier, Matthew, Presciutti, Steven, Schol, Jordy, Takeoka, Yoshiki, Yurube, Takashi, Zhang, Yejia, Masuda, Koichi, Iatridis, James C.

“…Background The rabbit lumbar spine is a commonly utilized model for studying intervertebral disc degeneration and for the pre‐clinical evaluation of…”
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Effects of Traction on Structural Properties of Degenerated Disc Using an In Vivo Rat-Tail Model by LAI, Alon, CHOW, Daniel H. K

“…An in vivo rat-tail model was adopted to study the structural changes of degenerated intervertebral disc after different traction protocols. To investigate the…”
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A perspective on the ORS Spine Section initiative to develop a multi‐species JOR Spine histopathology series by Dahia, Chitra L., Engiles, Julie B., Gullbrand, Sarah E., Iatridis, James C., Lai, Alon, Le Maitre, Christine L., Lotz, Jeffrey C., Masuda, Koichi, Séguin, Cheryle A., Tryfonidou, Marianna A.

“…This perspective summarizes the genesis, development, and potential future directions of the multispecies JOR Spine histopathology series…”
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Carry-over effects of backpack carriage on trunk posture and repositioning ability by Hung-Kay Chow, Daniel, Kit-Fong Hin, Cherry, Ou, Debbie, Lai, Alon

“…Immediate effects of backpack carriage on spinal curvature and motor control in adults have been reported. However, there is a scarcity of evidence whether the…”
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Effects of Panax ginseng-containing herbal plasters on compressed intervertebral discs in an in vivo rat tail model by Chow, Daniel H K, Lai, Alon, Tang, Fuk-Hay, Leung, Mason C P

“…Tienchi (Panax notoginseng) has been used in conservative treatments for back pain as a major ingredient of many herbal medicines. This study aims to…”
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Males and females exhibit distinct relationships between intervertebral disc degeneration and pain in a rat model by Mosley, Grace E., Wang, Minghui, Nasser, Philip, Lai, Alon, Charen, Daniel A., Zhang, Bin, Iatridis, James C.

“…Back pain is linked to intervertebral disc (IVD) degeneration, but clinical studies show the relationship is complex. This study assessed whether males and…”
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Looking beyond the intervertebral disc: the need for behavioral assays in models of discogenic pain by Mosley, Grace E., Evashwick‐Rogler, Thomas W., Lai, Alon, Iatridis, James C.

“…Orthopedic research into chronic discogenic back pain has commonly focused on aging‐ and degeneration‐related changes in intervertebral disc structure,…”
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Sex Differences in Rat Intervertebral Disc Structure and Function Following Annular Puncture Injury by Mosley, Grace E., Hoy, Robert C., Nasser, Philip, Kaseta, Timothy, Lai, Alon, Evashwick-Rogler, Thomas W., Lee, Michael, Iatridis, James C.

“…STUDY DESIGN.A rat puncture injury intervertebral disc (IVD) degeneration model with structural, biomechanical, and histological analyses. OBJECTIVE.To…”
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Ex-vivo biomechanics of repaired rat intervertebral discs using genipin crosslinked fibrin adhesive hydrogel by Fujii, Kengo, Lai, Alon, Korda, Nimrod, Hom, Warren W., Evashwick-Rogler, Thomas W., Nasser, Philip, Hecht, Andrew C., Iatridis, James C.

“…Microdiscectomy is the current standard surgical treatment for intervertebral disc (IVD) herniation, however annulus fibrosus (AF) defects remain unrepaired…”
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