Search Results - "Lahti, Robert A"

Antipsychotic Properties of the Partial Dopamine Agonist (−)-3-(3-Hydroxyphenyl)-N-n-Propylpiperidine (Preclamol) in Schizophrenia by Lahti, Adrienne C, Weiler, Martin A, Corey, Patricia K, Lahti, Robert A, Carlsson, Arvid, Tamminga, Carol A

“…Background: In an ongoing effort to characterize the clinical pharmacologic profile of the partial dopamine agonist…”
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(S)-(−)-4-[4-[2-(Isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide, a Selective Dopamine D4 Antagonist by TenBrink, Ruth E, Bergh, Carol L, Duncan, J. Neil, Harris, Douglas W, Huff, R. M, Lahti, Robert A, Lawson, Charles F, Lutzke, Barry S, Martin, Iain J, Rees, Susan A, Schlachter, Siusaidh K, Sih, John C, Smith, Martin W

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D2-type dopamine receptors in postmortem human brain sections from normal and schizophrenic subjects by Lahti, R A, Roberts, R C, Conley, R R, Cochrane, E V, Mutin, A, Tamminga, C A

“…The density of the presumed dopamine D4 receptor ([3H]YM-09151-2 minus [3H]raclopride), as well as the densities of the two ligands themselves were compared in…”
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Regional expression of RGS4 mRNA in human brain by Erdely, Holly A., Lahti, Robert A., Lopez, Mary B., Myers, Carol S., Roberts, Rosalinda C., Tamminga, Carol A., Vogel, Michael W.

“…Regulators of G‐protein signalling (RGS) proteins are a recently discovered class of proteins that modulate G‐protein activity. More than 20 RGS proteins have…”
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D2-family receptor distribution in human postmortem tissue: an autoradiographic study by Lahti, R A, Roberts, R C, Tamminga, C A

“…The distribution throughout the normal human brain of the dopamine D2-family of receptors were investigated autoradiographically. Three ligands were used,…”
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Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications by Lahti, R A, Evans, D L, Stratman, N C, Figur, L M

“…The dopamine D4 receptor, which is considered a close variant of the dopamine D2 receptor, has recently been cloned. Receptor binding studies demonstrated that…”
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Clinical Genetics, V : Association of Genetic and Personality Characteristics by Lahti, Robert A., Lahti, Adrienne C.

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Comparison of 5-HT1A and dopamine D2 pharmacophores. X-ray structures and affinities of conformationally constrained ligands by Chidester, Connie G, Lin, Chiu Hong, Lahti, Robert A, Haadsma-Svensson, Susanne R, Smith, Martin W

“…Conformational and molecular mechanics studies of a new series of tricyclic ligands with affinity for either the dopamine D2 receptor or the 5-HT1A receptor,…”
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Synthesis and pharmacology of novel anxiolytic agents derived from 2-[(dialkylamino)methyl-4H-triazol-4-yl]benzophenones and related heterocyclic benzophenones by Gall, Martin, Hester, J. B, Rudzik, A. D, Lahti, Robert A

“…A series of novel [(dialkylamino)methyl-4H-1,2,4-triazol-4-yl]benzophenones and related compounds has been prepared via total synthesis from substituted…”
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Centrally acting serotonergic and dopaminergic agents. 2. Synthesis and structure-activity relationships of 2,3,3a,4,9,9a-hexahydro-1H-benz[f]indole derivatives by Lin, Chiu Hong, Haadsma-Svensson, Susanne R, Phillips, Gillian, Lahti, Robert A, McCall, Robert B, Piercey, Montford F, Schreur, Peggy J. K. D, Von Voigtlander, Phillip F, Smith, Martin W, Chidester, Connie G

“…The conformationally restricted linear tricyclic analogs of 5- and 8-hydroxy-2-(di-n-propylamino)-tetralins were investigated for their serotonergic and…”
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Factors affecting binding of trans-N-[2-(methylamino)cyclohexyl]benzamides at the primary morphine receptor by Cheney, B. Vernon, Szmuszkovicz, Jacob, Lahti, Robert A, Zichi, Dominic A

“…In this paper, we describe the synthesis of a series of trans-N-[2-(methylamino)cyclohexyl]benzamides possessing morphine-like pharmacological properties. The…”
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Centrally acting serotonergic and dopaminergic agents. 1. Synthesis and structure-activity relationships of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives by Lin, Chiu Hong, Haadsma-Svensson, Susanne R, Lahti, Robert A, McCall, Robert B, Piercey, Montford F, Schreur, Peggy J. K. D, Von Voigtlander, Phillip F, Smith, Martin W, Chidester, Connie G

“…The synthesis and structure-activity relationships (SAR) of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives (3) are described. These compounds are…”
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Centrally acting serotonergic agents. Synthesis and structure-activity relationships of C-1- or C-3-substituted derivatives of 8-hydroxy-2-(di-n-propylamino)tetralin by Lin, Chiu Hong, Haadsma-Svensson, Susanne R, Lahti, Robert A, McCall, Robert B, Piercey, Montford F, Schreur, Peggy J. K. D, VonVoigtlander, Philip F, Chidester, Connie G

“…The synthesis and structure-activity relationships (SAR) of C-1- or C-3-substituted derivatives of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) are…”
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Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor by Ennis, Michael D, Baze, Mark E, Smith, Martin W, Lawson, Charles F, McCall, Robert B, Lahti, Robert A, Piercey, Montford F

“…The synthesis and biological evaluation of a new family of tricyclic indolodioxanes is described. These compounds all contain the…”
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Localization Of The Dopamine D4 Receptor In Rat Brain -- An Autoradiographic Study Using [3H]--YM 09151-2 by Stratman, Nancy C, Lahti, Robert A

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Conversion of N-alkylaminobenzophenones to benzodiazepines in vivo by Lahti, Robert A, Gall, Martin

“…The results of this study suggest that 5-chloro-2-[3-methyl-5-(dimethylamino)methyltriazol-4-yl]benzophenone can undergo N-dealkylation and ring closure in…”
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( S )-(−)-4-[4-[2-(Isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide, a Selective Dopamine D 4 Antagonist by TenBrink, Ruth E., Bergh, Carol L., Duncan, J. Neil, Harris, Douglas W., Huff, R. M., Lahti, Robert A., Lawson, Charles F., Lutzke, Barry S., Martin, Iain J., Rees, Susan A., Schlachter, Siusaidh K., Sih, John C., Smith, Martin W.

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Images in neuroscience: Clinical genetics, V by Lahti, Robert A, Lahti, Adrienne C

“…The distinctive functional characteristic that the D4,7 variant of the D4 dopamine receptor brings (excitability/impulsiveness) to the human brain is…”
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[3H]U-69593 a highly selective ligand for the opioid kappa receptor by Lahti, R A, Mickelson, M M, McCall, J M, Von Voigtlander, P F

“…The selective kappa agonist U-50488 was recently discovered and characterized. In this study, the receptor binding properties of [3H]U-69593, an analog of…”
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Effect Of amphetamine, α-Methyl-P-tyrosine (α-MPT) and antipsychotic agents on dopamine D 2-type receptor occupancy in rats by Lahti, Robert A., Tamminga, Carol A.

“…1. 1. EEDQ inactivates unoccupied receptors vivo in brain tissue and is useful in determining which receptors are occupied by a drug treatment. 2. 2. α-MPT,…”
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