Search Results - "Lahti, A. C."

Ketamine modulates hippocampal neurochemistry and functional connectivity: a combined magnetic resonance spectroscopy and resting-state fMRI study in healthy volunteers by Kraguljac, N V, Frölich, M A, Tran, S, White, D M, Nichols, N, Barton-McArdle, A, Reid, M A, Bolding, M S, Lahti, A C

“…A growing body of evidence suggests glutamate excess in schizophrenia and that N -methyl- d -aspartate receptor (NMDAR) hypofunction on γ-aminobutyric acid…”
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Decreased synaptic and mitochondrial density in the postmortem anterior cingulate cortex in schizophrenia by Roberts, R.C, Barksdale, K.A, Roche, J.K, Lahti, A.C

“…Abstract Schizophrenia (SZ) is a mental illness characterized by psychosis, negative symptoms, and cognitive deficits. The anterior cingulate cortex (ACC), a…”
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Synaptic Proteins in the Postmortem Anterior Cingulate Cortex in Schizophrenia: Relationship to Treatment and Treatment Response by BARKSDALE, K. A, LAHTI, A. C, ROBERTS, Rosalinda C

“…The anterior cingulate cortex (ACC) is one of several brain regions that are abnormal in schizophrenia (SZ). Here we compared markers of synapse and…”
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A Pre-clinical Study of the Response Threshold of Intact and Transected Nerves to Stimulation by Transcutaneous Intense Focused Ultrasound by Bobola, MS, Ezeokeke, CK, Kuznetslova, K, Lahti, AC, Loeser, JD, Olmstead, TA, Friedly, JL, Mourad, PD

“…We used diagnostic ultrasound imaging to guide individual bursts (0.1 s) of 2 MHz intense focused ultrasound (iFU) to determine the sensitivity of intact and…”
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Subanesthetic doses of ketamine stimulate psychosis in schizophrenia by Lahti, Adrienne C., Koffel, Bettylou, LaPorte, David, Tamminga, Carol A.

“…We administered ketamine to schizophrenic individuals in a double-blind, placebo-controlled design using a range of subanesthetic doses (0.1, 0.3, and 0.5…”
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How Low Should You Go? Determining the Optimal Cutoff for Exhaled Carbon Monoxide to Confirm Smoking Abstinence When Using Cotinine as Reference by Cropsey, Karen L., Trent, Lindsay R., Clark, Charles B., Stevens, Erin N., Lahti, Adrienne C., Hendricks, Peter S.

“…Confirming abstinence during smoking cessation clinical trials is critical for determining treatment effectiveness. Several biological methods exist for…”
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Abnormal Patterns of Regional Cerebral Blood Flow in Schizophrenia With Primary Negative Symptoms During an Effortful Auditory Recognition Task by Lahti, Adrienne C., Holcomb, Henry H., Medoff, Deborah R., Weiler, Martin A., Tamminga, Carol A., Carpenter, William T.

“…OBJECTIVE: Using functional brain imaging, the authors sought to replicate their earlier finding of low metabolism in the middle frontal and inferior parietal…”
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Ketamine activates psychosis and alters limbic blood flow in schizophrenia by Lahti, A C, Holcomb, H H, Medoff, D R, Tamminga, C A

“…The non-competitive NMDA antagonist ketamine, given to schizophrenic individuals in subanesthetic doses, produced a short-lived, discrete activation of their…”
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Antipsychotic Properties of the Partial Dopamine Agonist (−)-3-(3-Hydroxyphenyl)-N-n-Propylpiperidine (Preclamol) in Schizophrenia by Lahti, Adrienne C, Weiler, Martin A, Corey, Patricia K, Lahti, Robert A, Carlsson, Arvid, Tamminga, Carol A

“…Background: In an ongoing effort to characterize the clinical pharmacologic profile of the partial dopamine agonist…”
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Brain Activation Patterns in Schizophrenic and Comparison Volunteers During a Matched-Performance Auditory Recognition Task by Holcomb, Henry H., Lahti, Adrienne C., Medoff, Deborah R., Weiler, Martin, Dannals, Robert F., Tamminga, Carol A.

“…OBJECTIVE: The biological characteristics of schizophrenia are often studied by using functional imaging techniques. However, since volunteers with…”
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Effects of the D3 and autoreceptor-preferring dopamine antagonist (+)-UH232 in schizophrenia by LAHTI, A. C, WEILER, M, CARLSSON, A, TAMMINGA, C. A

“…The aminotetralin derivative (+)-UH232 is a dopamine-receptor antagonist with complex pharmacological properties, including a 4:1 selectivity for the D3 vs. D2…”
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Effects of Ketamine in Normal and Schizophrenic Volunteers by Lahti, Adrienne C, Weiler, Martin A, Tamara Michaelidis, B.A, Parwani, Arti, Tamminga, Carol A

“…This study evaluates the effects of ketamine on healthy and schizophrenic volunteers (SVs) in an effort to define the detailed behavioral effects of the drug…”
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A Full-Brain, Bootstrapped Analysis of Diffusion Tensor Imaging Robustly Differentiates Parkinson Disease from Healthy Controls by Skidmore, F. M., Spetsieris, P. G., Anthony, T., Cutter, G. R., von Deneen, K. M., Liu, Y., White, K. D., Heilman, K. M., Myers, J., Standaert, D. G., Lahti, A. C., Eidelberg, D., Ulug, A. M.

“…There is a compelling need for early, accurate diagnosis of Parkinson’s disease (PD). Various magnetic resonance imaging modalities are being explored as an…”
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The new generation of antipsychotic drugs by Tamminga, C A, Lahti, A C

“…New neuroleptic drugs are being developed for the treatment of schizophrenia and other psychoses. Clozapine and risperidone are available for general use…”
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Eye Tracking Disorder in Schizophrenia Is Characterized by Specific Ocular Motor Defects and Is Associated with the Deficit Syndrome by Ross, David E., Thaker, Gunvant K., Buchanan, Robert W., Kirkpatrick, Brian, Lahti, Adrienne C., Medoff, Deborah, Bartko, John J., Goodman, Jason, Tien, Allen

“…The objective was to determine the relationships between eye tracking disorder (ETD) in schizophrenia, specific ocular motor measures, and the deficit…”
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Glutamate pharmacology and the treatment of schizophrenia: current status and future directions by Tamminga, C A, Holcomb, H H, Gao, X M, Lahti, A C

“…Glutamate-containing neuronal terminals are ubiquitous in the central nervous system and their functional importance in mental activity is considerable…”
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The limbic cortex in schizophrenia: focus on the anterior cingulate by Tamminga, Carol A, Vogel, Michael, Gao, Xue-Min, Lahti, Adrienne C, Holcomb, Henry H

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Probing the human hippocampus using rCBF: Contrasts in schizophrenia by Medoff, Deborah R., Holcomb, Henry H., Lahti, Adrienne C., Tamminga, Carol A.

“…Regional cerebral blood flow (rCBF) data from two PET‐15O water schizophrenia studies were analyzed using individually placed, magnetic resonance (MR)‐guided…”
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Association Between Eye Tracking Disorder in Schizophrenia and Poor Sensory Integration by Ross, David E., Buchanan, Robert W., Medoff, Deborah, Lahti, Adrienne C., Thaker, Gunvant K.

“…Objective:The authors tested the hypothesis that eye tracking disorder in schizophrenia is associated with neurological signs.Method:The subjects were 93…”
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Recent developments in the neuropharmacology of schizophrenia by Lahti, A C, Tamminga, C A

“…Recent developments in the neuropharmacology of schizophrenia are discussed. Research in the pathophysiology of schizophrenia has enhanced our understanding of…”
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