Search Results - "Lahm, H."

Generation of three CRISPR/Cas9 edited human induced pluripotent stem cell lines (DHMi005-A-5, DHMi005-A-6 and DHMi005-A-7) carrying a Holt-Oram Syndrome patient-specific TBX5 mutation with known cardiac phenotype and a FLAG-tag after exon 9 of the TBX5 gene by Lahm, H., Stieglbauer, S., Neb, I., Doppler, S., Schneider, S., Dzilic, E., Lange, R., Krane, M., Dreßen, M.

“…TBX5 is a transcription factor (TF) playing essential role during cardiogenesis. It is well known that TF mutations possibly result in non- or additional…”
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Generation of two CRISPR/Cas edited human induced pluripotent stem cell lines (DHMi005-A-3 and DHMi005-A-4) carrying a FLAG-tag after exon 9 of the TBX5 gene by Lahm, H., Stieglbauer, S., Neb, I., Doppler, S.A., Schneider, S., Dzilic, E., Lange, R., Krane, M., Dreßen, M.

“…Although TBX5 plays a major role during human cardiogenesis and initiates and controls limb development, many of its interactions with genomic DNA and the…”
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Establishment of a patient-specific induced pluripotent stem cell line DHMi004-A from a male Holt-Oram syndrome patient with verified TBX5 mutation by Dreßen, M., Lahm, H., Neb, I., Luzius, T., Doppler, S.A., Schneider, S., Dzilic, E., Lange, R., Krane, M.

“…The Holt-Oram syndrome (HOS) is a rare autosomal dominant disorder, mostly based on mutations in the TBX5 gene. Patients show malformation of at least one…”
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Establishment of an induced pluripotent stem cell line DHMi005-A from a healthy male proband by Dreßen, M., Luzius, T., Lahm, H., Neb, I., Doppler, S.A., Schneider, S., Dzilic, E., Lange, R., Krane, M.

“…We generated an induced pluripotent stem cell (iPSC) line from a healthy male 29-year-old proband. Adipose fibroblasts (AFs) were reprogrammed using Sendai…”
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IGF-binding protein-5: flexible player in the IGF system and effector on its own by Schneider, MR, Wolf, E, Hoeflich, A, Lahm, H

“…The multiple activities of IGF-I and -II are modulated by a family of IGF-binding proteins (IGFBP-1 to -6). Although structurally related, each IGFBP has…”
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IGF-binding protein-4: biochemical characteristics and functional consequences by Zhou, R, Diehl, D, Hoeflich, A, Lahm, H, Wolf, E

“…IGFs have multiple functions regarding cellular growth, survival and differentiation under different physiological and pathological conditions. IGF effects are…”
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Corpuls CPR Generates Higher Mean Arterial Pressure Than LUCAS II in a Pig Model of Cardiac Arrest by Lange, R., Krane, M., Wolf, E., Heller, M., Polski, M., Xinghai, L., Stroh, A., Prinzing, A., Mendoza, A., Eichhorn, S., Lahm, H.

“…According to the European Resuscitation Council guidelines, the use of mechanical chest compression devices is a reasonable alternative in situations where…”
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Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2 by Hallek, Michael, Girod, Anne, Ried, Martin, Wobus, Christiane, Lahm, Harald, Leike, Kristin, Kleinschmidt, Jürgen, Deléage, Gilbert

“…The human parvovirus adeno-associated virus type 2 (AAV2) has many features that make it attractive as a vector for gene therapy. However, the broad host range…”
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Biophysical characterization of fungal phytases (Myo-Inositol hexakisphosphate phosphohydrolases): molecular size, glycosylation pattern, and engineering of proteolytic resistance by Wyss, M, Pasamontes, L, Friedlein, A, Remy, R, Tessier, M, Konenberger, A, Middendorf, A, Lehmann, M, Schnoebelen, L, Rothlisberger, U

“…Phytases (myo-inositol hexakisphosphate phosphohydrolases) are found naturally in plants and microorganisms, particularly fungi. Interest in these enzymes has…”
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Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor by Loetscher, H, Pan, Y C, Lahm, H W, Gentz, R, Brockhaus, M, Tabuchi, H, Lesslauer, W

“…Two distinct receptors for tumor necrosis factor (TNF) of 55 and 75 kd are expressed at low levels by various cells. The 55 kd TNF receptor was purified from…”
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Hydrolysis and amino acid composition analysis of proteins by Fountoulakis, Michael, Lahm, Hans-Werner

“…Amino acid composition analysis is a classical protein analysis method, which finds a wide application in medical and food science research and is…”
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Galectin-8 expression decreases in cancer compared with normal and dysplastic human colon tissue and acts significantly on human colon cancer cell migration as a suppressor by Nagy, N, Bronckart, Y, Camby, I, Legendre, H, Lahm, H, Kaltner, H, Hadari, Y, Van Ham, P, Yeaton, P, Pector, J-C, Zick, Y, Salmon, I, Danguy, A, Kiss, R, Gabius, H-J

“…Background and aims: Galectins are β-galactoside binding proteins. This ability may have a bearing on cell adhesion and migration/proliferation in human colon…”
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Mass spectrometry: A tool for the identification of proteins separated by gels by Lahm, Hans-Werner, Langen, Hanno

“…Mass spectrometry (MS) has become the technique of choice to identify proteins. This has been largely accomplished by the combination of high‐resolution…”
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Pressure Shift Freezing as Potential Alternative for Generation of Decellularized Scaffolds by Baier, D., Eichhorn, S., Horst, D., Schreiber, U., Lahm, H., Lange, R., Krane, M.

“…Background. Protocols using chemical reagents for scaffold decellularization can cause changes in the properties of the matrix, depending on the type of tissue…”
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Prognostic significance of cytokine modulation in non‐small cell lung cancer by Neuner, A., Schindel, M., Wildenberg, U., Muley, T., Lahm, H., Fischer, J.R.

“…Increased production of immunosuppressive interleukin‐10 (IL‐10) by non‐small cell lung cancer (NSCLC) and increased serum IL‐10 concentrations in…”
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Peri/nuclear localization of intact insulin-like growth factor binding protein-2 and a distinct carboxyl-terminal IGFBP-2 fragment in vivo by Hoeflich, A., Reisinger, R., Schuett, B.S., Elmlinger, M.W., Russo, V.C., Vargas, G.A., Jehle, P.M., Lahm, H., Renner-Müller, I., Wolf, E.

“…Insulin-like growth factor binding protein-2 (IGFBP-2) as one of the most important IGFBPs has never been assessed in the intracellular compartment in vivo…”
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Effect of the hydrolysis method on the determination of the amino acid composition of proteins by Weiss, Martin, Manneberg, Michael, Juranville, Jean-François, Lahm, Hans-Werner, Fountoulakis, Michael

“…Fast and reproducible separation and determination of amino acids serves the economical and reliable characterization and quantification of peptides and…”
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Human Catechol-O-Methyltransferase: Cloning and Expression of the Membrane- Associated Form by Bertocci, Barbara, Miggiano, Vincenzo, Da Prada, Mose, Dembic, Zlatko, Lahm, Hans-Werner, Malherbe, Parichehr

“…A cDNA clone for human catechol-O-methyltransferase (hCOMT; S-adenosyl-L-methionine:catechol O-methyltransferase; EC 2.1.1.6) was isolated from a human…”
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Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice by Zhou, R, Flaswinkel, H, Schneider, MR, Lahm, H, Hoeflich, A, Wanke, R, Wolf, E

“…Numerous in vitro studies have demonstrated that IGF-binding protein (IGFBP)-4 is a consistent inhibitor of IGF actions. In order to investigate the functions…”
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The Spliceosomal snRNP Core Complex of Trypanosoma brucei: Cloning and Functional Analysis Reveals Seven Sm Protein Constituents by Palfi, Zsofia, Lucke, Stephan, Lahm, Hans-Werner, Lane, William S., Kruft, Volker, Bragado-Nilsson, Elisabeth, Seraphin, Bertrand, Bindereif, Albrecht

“…Each of the trypanosome small nuclear ribonucleoproteins (snRNPs) U2, U4/U6, and U5, as well as the spliced leader (SL) RNP, contains a core of common…”
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