Search Results - "Laheij, Alexa M. G. A."

From Pathogenesis to Intervention: The Importance of the Microbiome in Oral Mucositis by Bruno, Julia S, Al-Qadami, Ghanyah H, Laheij, Alexa M G A, Bossi, Paolo, Fregnani, Eduardo R, Wardill, Hannah R

“…Oral mucositis (OM) is a common and impactful toxicity of standard cancer therapy, affecting up to 80% of patients. Its aetiology centres on the initial…”
Get full text

Late Complications in Long-Term Childhood Cancer Survivors: What the Oral Health Professional Needs to Know by Al-Ansari, Sali, Stolze, Juliette, Bresters, Dorine, Brook, Alan Henry, Laheij, Alexa M G A, Brand, Henk S, Dahllöf, Göran, Rozema, Frederik R, Raber-Durlacher, Judith E

“…With diagnostic and therapeutic advances, over 80% of children diagnosed with cancer become long-term survivors. As the number of childhood cancer survivors…”
Get full text

Pre-Chemotherapy Dental Screening: Is There Additional Diagnostic Value for a Panoramic Radiograph? by Zecha, Judith A E M, Laheij, Alexa M G A, Raber-Durlacher, Judith E, Westermann, Anneke M, de Lange, Jan, Smeele, Ludwig E

“…The oral cavity is a potential source of infectious complications in patients treated with myelosuppressive chemotherapy (CT). Pre-chemotherapy oral…”
Get full text

The impact of the oral cavity in febrile neutropenia and infectious complications in patients treated with myelosuppressive chemotherapy by Zecha, Judith A. E. M., Raber-Durlacher, Judith E., Laheij, Alexa M. G. A., Westermann, Anneke M., Epstein, Joel B., de Lange, Jan, Smeele, Ludi E.

“…Febrile neutropenia (FN) is an inflammatory response causing fever that may develop during cancer therapy-induced neutropenia. FN may herald life-threatening…”
Get full text

Oral health–related quality of life of patients with oral chronic graft-versus-host disease by Stolze, Juliette, Boor, Marlou, Hazenberg, Mette D., Brand, Henk S., Raber-Durlacher, Judith E., Laheij, Alexa M. G. A.

“…Purpose Symptoms of oral chronic graft-versus-host-disease (cGVHD) may significantly affect the oral health–related quality of life (OHRQoL). This study aimed…”
Get full text

Exploring the role of oral microorganisms in the pathogenesis of mucositis by assessing their impact on metabolic activity and reproductive capacity of epithelial cells in vitro by Haverman, Thijs M., Laheij, Alexa M. G. A., Nie, Min, Deng, Dong M., Raber-Durlacher, Judith E., de Soet, Johannes J., Rozema, Frederik R.

“…Purpose Clinical and in vitro studies showed selected oral microorganisms to be related to delayed wound healing and ulcerative oral mucositis. However, it is…”
Get full text

Salivary flow rate, subjective oral dryness and dental caries 5 years after haematopoietic cell transplantation by Bulthuis, Marjolein S, van Gennip, Lucky L A, Thomas, Renske Z, van Leeuwen, Stephanie J M, Bronkhorst, Ewald M, Laheij, Alexa M G A, Raber-Durlacher, Judith E, Blijlevens, Nicole M A, Huysmans, Marie-Charlotte D N J M

“…The aim of this study was to describe salivary flow rate, subjective oral dryness and dental caries 5 years post haematopoietic cell transplantation (HCT). HCT…”
Get full text

Oral bacteria and yeasts in relationship to oral ulcerations in hematopoietic stem cell transplant recipients by Laheij, Alexa M. G. A., de Soet, Johannes J., von dem Borne, Peter A., Kuijper, Ed J., Kraneveld, Eefje A., van Loveren, Cor, Raber-Durlacher, Judith E.

“…Background Oral mucositis is a serious and debilitating side effect of conditioning regimens for hematopoietic stem cell transplant (HSCT). Through HSCT, the…”
Get full text

Taste alterations after hematopoietic cell transplantation: a scoping review by Dequae, Caroline G. R., Raber-Durlacher, Judith E., Epstein, Joel B., de Vries, Ralph, Laheij, Alexa M. G. A.

“…Purpose This review aimed to evaluate the prevalence and characteristics of dysgeusia after hematopoietic cell transplantation (HCT). Methods A literature…”
Get full text

Updated perspectives on the contribution of the microbiome to the pathogenesis of mucositis using the MASCC/ISOO framework by Stringer, Andrea M., Hargreaves, Benjamin M., Mendes, Rui Amaral, Blijlevens, Nicole M. A., Bruno, Julia S., Joyce, Paul, Kamath, Srinivas, Laheij, Alexa M. G. A., Ottaviani, Giulia, Secombe, Kate R., Tonkaboni, Arghavan, Zadik, Yehuda, Bossi, Paolo, Wardill, Hannah R.

“…Advances in the treatment of cancer have significantly improved mortality rates; however, this has come at a cost, with many treatments still limited by their…”
Get full text

Proteins and peptides in parotid saliva of irradiated patients compared to that of healthy controls using SELDI-TOF-MS by Laheij, Alexa M G A, Rasch, Coen N, Brandt, Bernd W, de Soet, Johannes J, Schipper, Raymond G, Loof, Arnoud, Silletti, Erika, van Loveren, Cor

“…Radiotherapy to the head and neck area damages the salivary glands. As a consequence hyposalivation may occur, but also the protein composition of saliva may…”
Get full text

The effect of conditioning regimen and prescribed medications on hyposalivation in haematopoietic cell transplantation (HCT) patients: an 18-month prospective longitudinal study by Bulthuis, Marjolein S., van Gennip, Lucky L. A., Thomas, Renske Z., Bronkhorst, Ewald M., Laheij, Alexa M. G. A., Raber-Durlacher, Judith E., Rozema, Frederik R., Brennan, Michael T., von Bültzingslöwen, Inger, Blijlevens, Nicole M. A., Huysmans, Marie-Charlotte D. N. J. M., van Leeuwen, Stephanie J. M.

“…Objectives Haematopoietic cell transplantation (HCT) preceded by a conditioning regimen is an established treatment option for (non)malignant haematologic…”
Get full text

Periodontal status and bacteremia with oral viridans streptococci and coagulase negative staphylococci in allogeneic hematopoietic stem cell transplantation recipients: a prospective observational study by Raber-Durlacher, Judith E., Laheij, Alexa M. G. A., Epstein, Joel B., Epstein, Matthew, Geerligs, Gerard M., Wolffe, Gordon N., Blijlevens, Nicole M. A., Donnelly, J. Peter

“…Aim This study was aimed to investigate whether any association could be found between the presence of an inflamed and infected periodontium (e.g., gingivitis…”
Get full text

The Potential Contribution of Dental Foci and Oral Mucositis to Febrile Neutropenia in Patients Treated With Myelosuppressive Chemotherapy for Solid Tumors and Lymphoma by Zecha, Judith A. E. M., Raber-Durlacher, Judith E., Laheij, Alexa M. G. A., Westermann, Anneke M., de Lange, Jan, Smeele, Ludi E.

“…Introduction Febrile neutropenia (FN) is a potential life-threatening complication of myelosuppressive chemotherapy, particularly when induced by infection…”
Get full text

Taste and smell disturbances in patients with chronic oral graft vs. host disease: An observational study by Boor, Marlou, Raber-Durlacher, Judith E., Hazenberg, Mette D., Rozema, Frederik R., Laheij, Alexa M. G. A.

“…Background A common complication of allogeneic hematopoietic stem cell transplantation (alloHSCT) is chronic oral graft vs. host disease (cGvHD). Oral cGvHD…”
Get full text

Long-Term Analysis of Resilience of the Oral Microbiome in Allogeneic Stem Cell Transplant Recipients by Laheij, Alexa M G A, Rozema, Frederik R, Brennan, Michael T, von Bültzingslöwen, Inger, van Leeuwen, Stephanie J M, Potting, Carin, Huysmans, Marie-Charlotte D N J M, Hazenberg, Mette D, Brandt, Bernd W, Zaura, Egija, Buijs, Mark J, de Soet, Johannes J, Blijlevens, Nicole N M, Raber-Durlacher, Judith E

“…Stem cell transplantation (SCT) is associated with oral microbial dysbiosis. However, long-term longitudinal data are lacking. Therefore, this study aimed to…”
Get full text

Candida and Porphyromonas gingivalis: the effect on wound closure in vitro by Haverman, Thijs M., Laheij, Alexa M. G. A., de Soet, Johannes J., de Lange, Jan, Rozema, Frederik R.

“…Microorganisms play a role in oral mucositis after cancer therapy. The current study explored the hypothesis that Candida spp. alone and together with…”
Get full text

The impact of virulence factors of Porphyromonas gingivalis on wound healing in vitro by Laheij, Alexa M. G. A., van Loveren, Cor, Deng, Dongmei, de Soet, Johannes J.

“…Porphyromonas gingivalis inhibits oral epithelial wound healing in vitro more strongly than other oral bacteria, but it is unknown why P. gingivalis is such a…”
Get full text

The Influence of Oral Bacteria on Epithelial Cell Migration In Vitro by van Loveren, Cor, Bolscher, Jan G. M., Veerman, Enno C. I., de Soet, Johannes J., Laheij, Alexa M. G. A.

“…Oral ulcerations often arise as a side effect from chemo- and radiation therapy. In a previous clinical study, Porphyromonas gingivalis was identified as a…”
Get full text

The microbiological load and microbiome of the Dutch dental unit; ‘please, hold your breath’ by Hoogenkamp, Michel A., Brandt, Bernd W., Laheij, Alexa M.G.A., de Soet, Johannes J., Crielaard, Wim

“…•The majority of dental unit water in the Netherlands exceeds prevention guidelines.•Determination of heterotrophic plate counts of the effluent is not…”
Get full text