Increasing frequency of Gram-positive bacteria in spontaneous bacterial peritonitis

: Aim: To evaluate the characteristics and possible recent changes of the microbial causes of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. Methods: We retrospectively evaluated 42 cirrhotic patients with positive ascitic fluid culture and without evidence of secondary peritonitis w...

Full description

Saved in:

Bibliographic Details
Published in:	Liver international Vol. 25; no. 1; pp. 57 - 61
Main Authors:	Cholongitas, Evangelos, Papatheodoridis, George V., Lahanas, Alexandros, Xanthaki, Anna, Kontou-Kastellanou, Chrysoula, Archimandritis, Athanasios J.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Munksgaard International Publishers 01-02-2005
Subjects:	Aged Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use Ascites - etiology Ascites - microbiology cirrhosis Drug Resistance, Bacterial Female Gram-negative bacteria Gram-Negative Bacterial Infections - complications Gram-Negative Bacterial Infections - drug therapy Gram-Negative Bacterial Infections - pathology Gram-positive bacteria Gram-Positive Bacteria - drug effects Gram-Positive Bacteria - isolation & purification Gram-Positive Bacteria - physiology Gram-Positive Bacterial Infections - complications Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - pathology Humans Liver Cirrhosis - complications Liver Cirrhosis - pathology Male Middle Aged Peritonitis - microbiology Peritonitis - pathology quinolone resistance Quinolones - pharmacology Quinolones - therapeutic use spontaneous bacterial peritonitis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	: Aim: To evaluate the characteristics and possible recent changes of the microbial causes of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. Methods: We retrospectively evaluated 42 cirrhotic patients with positive ascitic fluid culture and without evidence of secondary peritonitis who were admitted consecutively to our Department between 1998 and 2002. Results: Twenty (48%) of 42 patients with positive ascitic fluid culture were diagnosed during 1998–1999 (period A) and the remaining 22 (52%) patients during 2000–2002 (period B). Gram‐negative bacteria were the cause of SBP in 15 (75%) of the 20 patients during period A and in only nine (41%) of the 22 patients during period B (P=0.026). SBP patients with Gram‐positive bacteria compared with those with Gram‐negative bacteria were less frequently in Child class C (P=0.058) and had significantly higher ascitic fluid protein (P=0.014) and albumin concentrations (P=0.009) and lower ascitic fluid neutrophil count (P=0.008). Resistance to quinolones was detected significantly more frequently in the isolated Gram‐positive than Gram‐negative bacteria (P<0.001). Conclusion: Culture‐positive SBP in cirrhotic patients are caused more frequently by Gram‐positive bacteria during the recent years, which are, in their vast majority, resistant to quinolones.
Bibliography:	ark:/67375/WNG-PGTXKFM2-V istex:292F8B41978F5B8E51DCC7379A0083ED2468E47B ArticleID:LIV985 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1478-3223 1478-3231
DOI:	10.1111/j.1478-3231.2004.0985.x