Frequencies of MICA alleles in patients from southern Brazil with multibacillary and paucibacillary leprosy

Frequencies of MICA alleles in patients from southern Brazil with multibacillary and paucibacillary leprosy

Summary Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which mainly affects the skin and nervous system. The disease has several clinical forms. This study investigated the MICA and HLA‐B genes in 223 samples from leprosy patients and 201 samples from healthy individuals mat...

Full description

Saved in:
Bibliographic Details
Published in:International journal of immunogenetics Vol. 39; no. 3; pp. 210 - 215
Main Authors: Sergio do Sacramento, W., Mazini, P. S., Franceschi, D. A. S., de Melo, F. C., Braga, M. A., Sell, A. M., Tsuneto, L. T., Laguila Visentainer, J. E.
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01-06-2012
Subjects:
Adult
Aged
Aged, 80 and over
Alleles
Brazil
Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Genotyping Techniques - methods
Haplotypes - genetics
Histocompatibility Antigens Class I - genetics
HLA-B Antigens - genetics
Humans
Leprosy, Multibacillary - genetics
Leprosy, Paucibacillary - genetics
Linkage Disequilibrium
Male
Middle Aged
Young Adult
Brazil
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which mainly affects the skin and nervous system. The disease has several clinical forms. This study investigated the MICA and HLA‐B genes in 223 samples from leprosy patients and 201 samples from healthy individuals matched for age, gender and ethnical background. Of the patients, 153 had multibacillary, 45 paucibacillary and 25 indeterminate leprosy. The aim of this case–control study was to assess whether the MICA alleles influence susceptibility for leprosy or affect the subtype of the disease in a population of southern Brazil. There were significant differences in frequencies of the MICA*027 allele (4.7% vs 1.8%, P‐value = 0.01, OR = 0.37; 95% CI = 0.16–0.85) between leprosy patients and controls, and of the MICA*010 (4.5% vs 1.6%, P‐value = 0.05, OR = 0.35, 95% CI = 0.13–0.97) and MICA*027 alleles (4.7% vs 1.3%, P‐value = 0.01; OR = 0.27; 95% CI = 0.09–0.79) between multibacillary leprosy patients and the control group. There were no significant differences in the frequency of MICA alleles between paucibacillary leprosy patients and controls. Thus, the MICA*027 allele is associated with a protective effect for leprosy per se, while the MICA*010 and MICA*027 alleles are associated with protection against multibacillary leprosy, the most severe clinical subtype.
Bibliography:istex:F33E1036C58B57F7DC32016B9A8D0CDADE5AAD2B
ArticleID:IJI1074
ark:/67375/WNG-V1G4S8PS-T
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1744-3121
1744-313X
DOI:10.1111/j.1744-313X.2011.01074.x