Search Results - "Lagrange, Andre H"

Region and layer-specific expression of GABAA receptor isoforms and KCC2 in developing cortex by Zavalin, Kirill, Hassan, Anjana, Zhang, Yueli, Khera, Zain, Lagrange, Andre H.

“…Introduction γ-Aminobutyric acid (GABA) type A receptors (GABA A Rs) are ligand-gated Cl-channels that mediate the bulk of inhibitory neurotransmission in the…”
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Diagnostic and therapeutic aspects of Hashimoto's encephalopathy by Olmez, Inan, Moses, Harold, Sriram, Subramaniam, Kirshner, Howard, Lagrange, Andre H, Pawate, Siddharama

“…Abstract Objective To share our experience on clinical presentation and management of patients diagnosed with Hashimoto's Encephalopathy (HE) at Vanderbilt…”
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Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons by Zavalin, Kirill, Hassan, Anjana, Fu, Cary, Delpire, Eric, Lagrange, Andre H

“…K-Cl transporter KCC2 is an important regulator of neuronal development and neuronal function at maturity. Through its canonical transporter role, KCC2…”
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Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination by Grier, Mark D, West, Kathryn L, Kelm, Nathaniel D, Fu, Cary, Does, Mark D, Parker, Brittany, McBrier, Eleanor, Lagrange, Andre H, Ess, Kevin C, Carson, Robert P

“…Myelin abnormalities are increasingly being recognized as an important component of a number of neurologic developmental disorders. The integration of many…”
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Temporal lobe origin is common in patients who have undergone epilepsy surgery for hypermotor seizures by Arain, Amir M, Azar, Nabil J, Lagrange, Andre H, McLean, Michael, Singh, Pradumna, Sonmezturk, Hasan, Konrad, Peter, Neimat, Joseph, Abou-Khalil, Bassel

“…Abstract Rationale Hypermotor seizures are most often reported from the frontal lobe but may also have temporal, parietal, or insular origin. We noted a higher…”
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Glycosylation of β2 Subunits Regulates GABAA Receptor Biogenesis and Channel Gating by Lo, Wen-yi, Lagrange, Andre H., Hernandez, Ciria C., Harrison, Rebecca, Dell, Anne, Haslam, Stuart M., Sheehan, Jonathan H., Macdonald, Robert L.

“…γ-Aminobutyric acid type A (GABAA) receptors are heteropentameric glycoproteins. Based on consensus sequences, the GABAA receptor β2 subunit contains three…”
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GABA beyond the synapse: defining the subtype-specific pharmacodynamics of non-synaptic GABA A receptors by Lagrange, Andre H, Hu, NingNing, Macdonald, Robert L

“…Physiologically relevant combinations of recombinant GABA receptor (GABAR) subunits were expressed in HEK293 cells. Using whole-cell voltage clamp and rapid…”
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Mutations in the GABRA1 and EFHC1 genes are rare in familial juvenile myoclonic epilepsy by Ma, Shaochun, Blair, Marcia A., Abou-Khalil, Bassel, Lagrange, Andre H., Gurnett, Christina A., Hedera, Peter

“…Juvenile myoclonic epilepsy (JME), accounting for approximately 25% of idiopathic generalized epilepsies, is genetically heterogeneous. Mutations in the…”
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Altered inhibitory synapses in de novo GABRA5 and GABRA1 mutations associated with early onset epileptic encephalopathies by Hernandez, Ciria C, XiangWei, Wenshu, Hu, Ningning, Shen, Dingding, Shen, Wangzhen, Lagrange, Andre H, Zhang, Yujia, Dai, Lifang, Ding, Changhong, Sun, Zhaohui, Hu, Jiasheng, Zhu, Hongmin, Jiang, Yuwu, Macdonald, Robert L

“…We performed next generation sequencing on 1696 patients with epilepsy and intellectual disability using a gene panel with 480 epilepsy-related genes including…”
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GABA beyond the synapse: defining the subtype‐specific pharmacodynamics of non‐synaptic GABAA receptors by Lagrange, Andre H., Hu, NingNing, Macdonald, Robert L.

“…Key points Physiologically relevant combinations of recombinant GABAA receptor (GABAR) subunits were expressed in HEK293 cells. Using whole‐cell voltage clamp…”
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Detection challenges of temporal encephaloceles in epilepsy: A retrospective analysis by Ortiz, Alexander V., Eisma, Jarrod J., Martin, Dann, Lagrange, Andre H., Motuzas, Cari, Nobis, William, Abou-Khalil, Bassel W., Morgan, Victoria L., Fox, Jonah

“…Temporal encephaloceles (TEs) are herniations of cerebral parenchyma through structural defects in the floor of the middle cranial fossa. They are a relatively…”
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Of Blobs and Buzzes: Does SISCOM Imaging Actually Help SEEG Planning? by Englot, Dario J., Lagrange, Andre H.

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Comparison of γ-Aminobutyric Acid, Type A (GABAA), Receptor αβγ and αβδ Expression Using Flow Cytometry and Electrophysiology: EVIDENCE FOR ALTERNATIVE SUBUNIT STOICHIOMETRIES AND ARRANGEMENTS by Botzolakis, Emmanuel J, Gurba, Katharine N, Lagrange, Andre H, Feng, Hua-Jun, Stanic, Aleksandar K, Hu, Ningning, Macdonald, Robert L

“…The subunit stoichiometry and arrangement of synaptic αβγ GABAA receptors are generally accepted as 2α:2β:1γ with a β-α-γ-β-α counterclockwise configuration,…”
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Estrogen modulation of K + channel activity in hypothalamic neurons involved in the control of the reproductive axis by Kelly, Martin J., Rønnekleiv, Oline K., Ibrahim, Nurhadi, Lagrange, Andre H., Wagner, Edward J.

“…Here we report on the progress we have made in elucidating the mechanisms through which estrogen alters synaptic responses in hypothalamic neurons. We examined…”
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Generalized onset seizures with focal evolution (GOFE) — A unique seizure type in the setting of generalized epilepsy by Linane, Avriel, Lagrange, Andre H, Fu, Cary, Abou-Khalil, Bassel

“…Abstract Purpose We report clinical and electrographic features of generalized onset seizures with focal evolution (GOFE) and present arguments for the…”
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Of mothers and myelin: Aberrant myelination phenotypes in mouse model of Angelman syndrome are dependent on maternal and dietary influences by Grier, Mark D., Carson, Robert P., Lagrange, Andre H.

“…•AS mice have disrupted cortical myelin protein expression.•Maternal status influences myelin expression dramatically in this model.•A higher fat (11%) breeder…”
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Enhanced macroscopic desensitization shapes the response of α4 subtype‐containing GABAA receptors to synaptic and extrasynaptic GABA by Lagrange, Andre H., Botzolakis, Emmanuel J., Macdonald, Robert L.

“…Up‐regulation of the GABAA receptor α4 subunit subtype has been consistently shown in multiple animal models of chronic epilepsy. This isoform is expressed in…”
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Video-EEG results and clinical characteristics in patients with psychogenic nonepileptic spells: The effect of a coexistent epilepsy by Chen-Block, Stephanie, Abou-Khalil, Bassel W, Arain, Amir, Haas, Kevin F, Lagrange, Andre H, Gallagher, Martin J, Azar, Nabil J, Singh, Pradumna, Sonmezturk, Hasan H

“…Abstract Rationale Epilepsy and psychogenic nonepileptic spells (PNES) can coexist, often posing diagnostic and therapeutic challenges. We sought to identify…”
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Developmental modulation of GABA(A) receptor function by RNA editing by Rula, Elizabeth Y, Lagrange, Andre H, Jacobs, Michelle M, Hu, NingNing, Macdonald, Robert L, Emeson, Ronald B

“…Adenosine-to-inosine (A-to-I) editing of RNA transcripts is an increasingly recognized cellular strategy to modulate the function of proteins involved in…”
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Developmental Modulation of GABAA Receptor Function by RNA Editing by Rula, Elizabeth Y, Lagrange, Andre H, Jacobs, Michelle M, Hu, NingNing, Macdonald, Robert L, Emeson, Ronald B

“…Adenosine-to-inosine (A-to-I) editing of RNA transcripts is an increasingly recognized cellular strategy to modulate the function of proteins involved in…”
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