Association between GRM3 gene polymorphisms and response to treatment in Moroccan schizophrenic patients

The aim of this study is to evaluate the association between response to treatment in Moroccan schizophrenic patients and GRM3 gene polymorphisms. We have genotyped three SNPs of GRM3 gene (rs1989796, rs1468412, rs1476455) in 33 Moroccan schizophrenic patients. We assessed the severity of symptoms u...

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Bibliographic Details
Published in:	European psychiatry Vol. 41; no. S1; p. S818
Main Authors:	Lagouaiti, H., Zairy, G., Charoute, H., Somali, R., Atouche, N., Elalaoui, A., Battas, O., Agoub, M.
Format:	Journal Article
Language:	English
Published:	Elsevier Masson SAS 01-04-2017
Online Access:	Get full text
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Summary:	The aim of this study is to evaluate the association between response to treatment in Moroccan schizophrenic patients and GRM3 gene polymorphisms. We have genotyped three SNPs of GRM3 gene (rs1989796, rs1468412, rs1476455) in 33 Moroccan schizophrenic patients. We assessed the severity of symptoms using Positive and Negative Symptoms Scale (PANSS) and Brief Psychiatric Rating Scale (BPRS) during two months of antipsychotics treatment. The result revealed a positive change in PANSS negative symptoms in patients with rs1468412SNP and a difference in allele frequency of rs1989796SNP between responders and nonresponders to treatment. Our data indicate that rs1468412 and rs1989796 GRM3 gene polymorphisms play a role in response to schizophrenia treatment.
ISSN:	0924-9338 1778-3585
DOI:	10.1016/j.eurpsy.2017.01.1594