Search Results - "Lago, João Henrique"

Mechanism of Action of Thymol on Cell Membranes Investigated through Lipid Langmuir Monolayers at the Air–Water Interface and Molecular Simulation by Ferreira, João Victor N, Capello, Tabata M, Siqueira, Leonardo J. A, Lago, João Henrique G, Caseli, Luciano

“…A major challenge in the design of biocidal drugs is to identify compounds with potential action on microorganisms and to understand at the molecular level…”
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Thymol as Starting Material for the Development of a Biobased Material with Enhanced Antimicrobial Activity: Synthesis, Characterization, and Potential Application by Parolin, Giovana A, Vital, Vitor G, de Vasconcellos, Suzan P, Lago, João Henrique G, Péres, Laura O

“…A biobased material, polythymol (PTF), was prepared using thymol, a monoterpene obtained from the essential oil of (Lamiaceae), as a starting material with the…”
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Enyne acetogenins from Porcelia macrocarpa displayed anti-Trypanosoma cruzi activity and cause a reduction in the intracellular calcium level by Thevenard, Fernanda, Brito, Ivanildo A., Costa-Silva, Thais A., Tempone, Andre G., Lago, João Henrique G.

“…Natural products are a promising source of new compounds with a wide spectrum of pharmacological properties, including antiprotozoal activities. Chagas…”
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Structure-activity association of flavonoids in lung diseases by Lago, João Henrique G, Toledo-Arruda, Alessandra C, Mernak, Márcia, Barrosa, Kaidu H, Martins, Milton A, Tibério, Iolanda F L C, Prado, Carla M

“…Flavonoids are polyphenolic compounds classified into flavonols, flavones, flavanones, isoflavones, catechins, anthocyanidins, and chalcones according to their…”
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Neolignans isolated from Saururus cernuus L. (Saururaceae) exhibit efficacy against Schistosoma mansoni by Brito, Juliana R., Wilairatana, Polrat, Roquini, Daniel B., Parra, Beatriz C., Gonçalves, Marina M., Souza, Dalete Christine S., Ferreira, Edgard A., Salvadori, Maria C., Teixeira, Fernanda S., Lago, João Henrique G., de Moraes, Josué

“…Schistosomiasis, a parasitic disease caused by the blood fluke of the genus Schistosoma , affects over 230 million people, especially in developing countries…”
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Andrographolide: A Diterpenoid from Cymbopogon schoenanthus Identified as a New Hit Compound against Trypanosoma cruzi Using Machine Learning and Experimental Approaches by Barbosa, Henrique, Espinoza, Gabriel Zarzana, Amaral, Maiara, de Castro Levatti, Erica Valadares, Abiuzi, Mariana Babberg, Veríssimo, Gabriel Correa, Fernandes, Philipe de Oliveira, Maltarollo, Vinícius Gonçalves, Tempone, Andre Gustavo, Honorio, Kathia Maria, Lago, João Henrique Ghilardi

“…American Trypanosomiasis, also known as Chagas disease, is caused by the protozoan Trypanosoma cruzi and exhibits limited options for treatment. Natural…”
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Antiparasitic activity of piplartine (piperlongumine) in a mouse model of schistosomiasis by Mengarda, Ana.C., Mendonça, Poliana S., Morais, Cristiane S., Cogo, Ramon M., Mazloum, Susana F., Salvadori, Maria C., Teixeira, Fernanda S., Morais, Thiago R., Antar, Guilherme M., Lago, João Henrique G., Moraes, Josué

“…Schistosomiasis is one of the most important parasitic infections in terms of its negative effects on public health and economics. Since praziquantel is…”
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Evaluation of Anti- Trypanosoma cruzi Activity of Chemical Constituents from Baccharis sphenophylla Isolated Using High-Performance Countercurrent Chromatography by Silva, Matheus L, Sales, Felipe S, Levatti, Erica V C, Antar, Guilherme M, Tempone, Andre G, Lago, João Henrique G, Jerz, Gerold

“…Endemic in 21 countries, Chagas disease, also known as American Trypanosomiasis, is a neglected tropical disease (NTD) caused by the protozoan parasite . The…”
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Essential Oil Extracted from Lippia sidoides Cham. (Verbenaceae) Induces Cell Cycle Arrest, Apoptosis, and Antimigratory Effects in Melanoma Cells by Volpe-Fix, Andressa Roehrig, Sales, Felipe da Silva, Caperuto, Luciana Chagas, Machado-Junior, Joel, Lago, João Henrique G

“…Melanoma, the most aggressive form of skin cancer, poses a substantial global health threat with increasing incidence rates. Although novel targeted therapies…”
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Structurally Related Monoterpenes p-Cymene, Carvacrol and Thymol Isolated from Essential Oil from Leaves of Lippia sidoides Cham. (Verbenaceae) Protect Mice against Elastase-Induced Emphysema by Games, Ellen, Guerreiro, Marina, Santana, Fernanda R, Pinheiro, Nathalia M, de Oliveira, Emerson A, Lopes, Fernanda D T Q S, Olivo, Clarice R, Tibério, Iolanda F L C, Martins, Mílton A, Lago, João Henrique G, Prado, Carla M

“…Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction and inflammation. Natural products, such as monoterpenes,…”
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(-)-T-Cadinol-a Sesquiterpene Isolated From Casearia sylvestris (Salicaceae)-Displayed In Vitro Activity and Causes Hyperpolarization of the Membrane Potential of Trypanosoma cruzi by Dos Santos, Augusto L, Amaral, Maiara, Hasegawa, Flavia Rie, Lago, João Henrique G, Tempone, Andre G, Sartorelli, Patricia

“…Chagas disease is caused by the protozoan parasite and affects 6-8 million people worldwide, mainly from developing countries. The treatment is limited to two…”
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In vivo antischistosomal efficacy of Porcelia ponderosa γ-lactones by Souza, Dalete Christine S., Totini, Carlos H., Cajás, Rayssa A., Teixeira, Thainá R., Oliveira, Emerson A., Cirino, Maria E., Souza, Maria C., Salvadori, Maria C., Teixeira, Fernanda S., de Moraes, Josué, Lago, João Henrique G.

“…Schistosomiasis, caused by the parasitic blood fluke Schistosoma mansoni, is a significant global health concern, particularly in tropical and subtropical…”
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Dehydrodieugenol improved lung inflammation in an asthma model by inhibiting the STAT3/SOCS3 and MAPK pathways by Santana, Fernanda P.R., da Silva, Rafael C., Ponci, Vitor, Pinheiro, Aruanã J.M.C.R., Olivo, Clarice R., Caperuto, Luciana C., Arantes-Costa, Fernanda M., Claudio, Samuel R., Ribeiro, Daniel A., Tibério, Iolanda F.L.C., Lima-Neto, Lídio G., Lago, João Henrique G., Prado, Carla M.

“…[Display omitted] Eugenol, a common phenylpropanoid derivative found in different plant species, has well-described anti-inflammatory effects associated with…”
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Evaluation of the effects in cellular membrane models of antitrypanosomal poly-thymolformaldehyde (PTF) using Langmuir monolayers by Parolin, Giovana A, Gonçalves, Giulia E G, Costa-Silva, Thais A, Tempone, Andre G, Caseli, Luciano, Lago, João Henrique G, Péres, Laura O

“…The polymerization of bioactive compounds may be interesting because the supramolecular structures formed can boost biological action on microorganism…”
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Adenanthin Is an Efficient Inhibitor of Peroxiredoxins from Pathogens, Inhibits Bacterial Growth, and Potentiates Antibiotic Activities by dos Santos, Melina Cardoso, Tairum, Carlos Abrunhosa, Cabrera, Vitoria Isabela Montanhero, Guimarães Cauz, Ana Carolina, Ribeiro, Luiz Fernando, Toledo Junior, José Carlos, Toyama, Marcos Hikari, Lago, João Henrique Ghilardi, Brocchi, Marcelo, Netto, Luis Eduardo Soares, de Oliveira, Marcos Antonio

“…The emergence and re-emergence of bacterial strains resistant to multiple drugs represent a global health threat, and the search for novel biological targets…”
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Discovery of New Hits as Antitrypanosomal Agents by In Silico and In Vitro Assays Using Neolignan-Inspired Natural Products from Nectandra leucantha by Araujo, Sheila C., Sousa, Fernanda S., Costa-Silva, Thais A., Tempone, Andre G., Lago, João Henrique G., Honorio, Kathia M.

“…In the present study, the phytochemical study of the n-hexane extract from flowers of Nectandra leucantha (Lauraceae) afforded six known neolignans (1–6) as…”
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Metabolite profile of Nectandra oppositifolia Nees & Mart. and assessment of antitrypanosomal activity of bioactive compounds through efficiency analyses by Alves Conserva, Geanne A, Quirós-Guerrero, Luis M, Costa-Silva, Thais A, Marcourt, Laurence, Pinto, Erika G, Tempone, Andre G, Fernandes, João Paulo S, Wolfender, Jean-Luc, Queiroz, Emerson F, Lago, João Henrique G

“…EtOH extracts from the leaves and twigs of Nectandra oppositifolia Nees & Mart. shown activity against amastigote forms of Trypanosoma cruzi. These extracts…”
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Chemical composition and cytotoxicity evaluation of essential oil from leaves of Casearia sylvestris, its main compound α-zingiberene and derivatives by Bou, Diego Dinis, Lago, João Henrique G, Figueiredo, Carlos R, Matsuo, Alisson L, Guadagnin, Rafael C, Soares, Marisi G, Sartorelli, Patricia

“…Casearia sylvestris (Salicaceae), popularly known as "guaçatonga", is a plant widely used in folk medicine to treat various diseases, including cancer. The…”
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Antileishmanial Effects of Acetylene Acetogenins from Seeds of Porcelia macrocarpa (Warm.) R.E. Fries (Annonaceae) and Semisynthetic Derivatives by Brito, Ivanildo A, Thevenard, Fernanda, Costa-Silva, Thais A, Oliveira, Samuel S, Cunha, Rodrigo L O R, de Oliveira, Emerson A, Sartorelli, Patricia, Guadagnin, Rafael C, Romanelli, Maiara M, Tempone, Andre G, Lago, João Henrique G

“…As part of our continuous studies involving the prospection of natural products from Brazilian flora aiming at the discovery of prototypes for the development…”
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Saturated Iso-Type Fatty Acids from the Marine Bacterium Mesoflavibacter zeaxanthinifaciens with Anti-Trypanosomal Potential by Santos Ferreira, Dayana Agnes, de Castro Levatti, Erica Valadares, Santa Cruz, Lucas Monteiro, Costa, Alan Roberto, Migotto, Álvaro E, Yamada, Amanda Yaeko, Camargo, Carlos Henrique, Christodoulides, Myron, Lago, João Henrique G, Tempone, Andre Gustavo

“…Chagas disease is a Neglected Tropical Disease with limited and ineffective therapy. In a search for new anti-trypanosomal compounds, we investigated the…”
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