Search Results - "Laggai, Stephan"

Hepatocellular Carcinoma and Nuclear Paraspeckles: Induction in Chemoresistance and Prediction for Poor Survival by Kessler, Sonja M, Hosseini, Kevan, Hussein, Usama Khamis, Kim, Kyoung Min, List, Markus, Schultheiß, Christina S, Schulz, Marcel H, Laggai, Stephan, Jang, Kyu Yun, Kiemer, Alexandra K

“…Hepatocellular carcinoma (HCC) represents the second most common cause of cancer-related deaths worldwide, not least due to its high chemoresistance. The long…”
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The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis[S] by Laggai, Stephan, Kessler, Sonja M., Boettcher, Stefan, Lebrun, Valérie, Gemperlein, Katja, Lederer, Eva, Leclercq, Isabelle A., Mueller, Rolf, Hartmann, Rolf W., Haybaeck, Johannes, Kiemer, Alexandra K.

“…Liver-specific overexpression of the insulin-like growth factor 2 (IGF2) mRNA binding protein p62/IGF2BP2-2 induces a fatty liver, which highly expresses IGF2…”
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IGF2 mRNA binding protein p62/IMP2-2 in hepatocellular carcinoma: antiapoptotic action is independent of IGF2/PI3K signaling by Kessler, Sonja M, Pokorny, Juliane, Zimmer, Vincent, Laggai, Stephan, Lammert, Frank, Bohle, Rainer M, Kiemer, Alexandra K

“…The insulin-like growth factor II (IGF2) mRNA binding protein (IMP) p62/IMP2-2, originally isolated from a hepatocellular carcinoma (HCC) patient, induces a…”
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The mRNA-binding Protein TTP/ZFP36 in Hepatocarcinogenesis and Hepatocellular Carcinoma by Kröhler, Tarek, Kessler, Sonja M, Hosseini, Kevan, List, Markus, Barghash, Ahmad, Patial, Sonika, Laggai, Stephan, Gemperlein, Katja, Haybaeck, Johannes, Müller, Rolf, Helms, Volkhard, Schulz, Marcel H, Hoppstädter, Jessica, Blackshear, Perry J, Kiemer, Alexandra K

“…Hepatic lipid deposition and inflammation represent risk factors for hepatocellular carcinoma (HCC). The mRNA-binding protein tristetraprolin (TTP, gene name )…”
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Alterations in the hepatocyte epigenetic landscape in steatosis by Maji, Ranjan Kumar, Czepukojc, Beate, Scherer, Michael, Tierling, Sascha, Cadenas, Cristina, Gianmoena, Kathrin, Gasparoni, Nina, Nordström, Karl, Gasparoni, Gilles, Laggai, Stephan, Yang, Xinyi, Sinha, Anupam, Ebert, Peter, Falk-Paulsen, Maren, Kinkley, Sarah, Hoppstädter, Jessica, Chung, Ho-Ryun, Rosenstiel, Philip, Hengstler, Jan G, Walter, Jörn, Schulz, Marcel H, Kessler, Sonja M, Kiemer, Alexandra K

“…Fatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the…”
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The long non-coding RNA H19 suppresses carcinogenesis and chemoresistance in hepatocellular carcinoma by Schultheiss, Christina S, Laggai, Stephan, Czepukojc, Beate, Hussein, Usama K, List, Markus, Barghash, Ahmad, Tierling, Sascha, Hosseini, Kevan, Golob-Schwarzl, Nicole, Pokorny, Juliane, Hachenthal, Nina, Schulz, Marcel, Helms, Volkhard, Walter, Jörn, Zimmer, Vincent, Lammert, Frank, Bohle, Rainer M, Dandolo, Luisa, Haybaeck, Johannes, Kiemer, Alexandra K, Kessler, Sonja M

“…The long non-coding RNA (lncRNA) represents a maternally expressed and epigenetically regulated imprinted gene product and is discussed to have either…”
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Corrigendum: Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation by Kessler, Sonja M, Laggai, Stephan, Van Wonterghem, Elien, Gemperlein, Katja, Müller, Rolf, Haybaeck, Johannes, Vandenbroucke, Roosmarijn E, Ogris, Manfred, Libert, Claude, Kiemer, Alexandra K

“…[This corrects the article on p. 147 in vol. 7, PMID: 27199763.]…”
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Rapid chromatographic method to decipher distinct alterations in lipid classes in NAFLD/NASH by Laggai, Stephan, Simon, Yvette, Ranssweiler, Theo, Kiemer, Alexandra K, Kessler, Sonja M

“…AIM: To establish a simple method to quantify lipid classes in liver diseases and to decipher the lipid profile in p62/IMP2-2/IGF2BP2-2 transgenic…”
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First Small-Molecule Inhibitors Targeting the RNA-Binding Protein IGF2BP2/IMP2 for Cancer Therapy by Dahlem, Charlotte, Abuhaliema, Ali, Kessler, Sonja M, Kröhler, Tarek, Zoller, Ben G. E, Chanda, Shilpee, Wu, Yingwen, Both, Simon, Müller, Fabian, Lepikhov, Konstantin, Kirsch, Susanne H, Laggai, Stephan, Müller, Rolf, Empting, Martin, Kiemer, Alexandra K

“…The RNA-binding protein IGF2BP2/IMP2/VICKZ2/p62 is overexpressed in several tumor entities, promotes tumorigenesis and tumor progression, and has been…”
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Lack of Kupffer cell depletion in diethylnitrosamine-induced hepatic inflammation by Kessler, Sonja M., Hoppstädter, Jessica, Hosseini, Kevan, Laggai, Stephan, Haybaeck, Johannes, Kiemer, Alexandra K.

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Hepatic hepcidin expression is decreased in cirrhosis and HCC by Kessler, Sonja M, Laggai, Stephan, Kiemer, Alexandra K, Barghash, Ahmad, Helms, Volkhard

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Lack of Kupffer cell depletion in diethylnitrosamine-induced hepatic inflammation/Reply to: “Lack of Kupffer cell depletion in diethylnitrosamine-induced hepatic inflammation” by Kessler, Sonja M, Hoppstädter, Jessica, Hosseini, Kevan, Laggai, Stephan, Haybaeck, Johannes, Kiemer, Alexandra K, Borst, Katharina, Graalmann, Theresa, Kalinke, Ulrich

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Hepatic interleukin-6 production is maintained during endotoxin tolerance and facilitates lipid accumulation by Dembek, Anna, Laggai, Stephan, Kessler, Sonja M, Czepukojc, Beate, Simon, Yvette, Kiemer, Alexandra K, Hoppstädter, Jessica

“…Graphical abstract…”
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THU-470-The mRNA-binding protein tristetraprolin promotes hepatocarcinogenesis but inhibits tumour progression in liver cancer by Kessler, Sonja, Hosseini, Kevan, Kröhler, Tarek, Barghash, Ahmad, Patial, Sonika, Hoppstädter, Jessica, Gemperlein, Katja, Haybäck, Johannes, List, Markus, Müller, Rolf, Helms, Volkhard, Schulz, Marcel, Laggai, Stephan, Blackshear, Perry, Kiemer, Alexandra K.

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IMP2/IGF2BP2 expression, but not IMP1 and IMP3, predicts poor outcome in patients and high tumor growth rate in xenograft models of gallbladder cancer by Kessler, Sonja M, Lederer, Eva, Laggai, Stephan, Golob-Schwarzl, Nicole, Hosseini, Kevan, Petzold, Johannes, Schweiger, Caroline, Reihs, Robert, Keil, Marlen, Hoffmann, Jens, Mayr, Christian, Kiesslich, Tobias, Pichler, Martin, Kim, Kyung Sik, Rhee, Hyungjin, Park, Young Nyun, Lax, Sigurd, Obrist, Peter, Kiemer, Alexandra K, Haybaeck, Johannes

“…Overexpression of the oncofetal insulin-like growth factor 2 mRNA-binding protein 2 (IMP2/IGF2BP2) has been described in different cancer types. Gallbladder…”
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Lipid Metabolism Signatures in NASH-Associated HCC-Letter by KESSLER, Sonja M, LAGGAI, Stephan, BARGHASH, Ahmad, HELMS, Volkhard, KIEMER, Alexandra K

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Erratum to “Hepatic hepcidin expression is decreased in cirrhosis and HCC” [J Hepatol 2015;62:977–979] by Kessler, Sonja M, Barghash, Ahmad, Laggai, Stephan, Helms, Volkhard, Kiemer, Alexandra K

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Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation by Kessler, Sonja M, Laggai, Stephan, Van Wonterg, Elien, Gemperlein, Katja, Müller, Rolf, Haybaeck, Johannes, Vandenbroucke, Roosmarijn E, Ogris, Manfred, Libert, Claude, Kiemer, Alexandra K

“…Although insulin-like growth factor 2 (IGF2) has been reported to be overexpressed in steatosis and steatohepatitis, a causal role of IGF2 in steatosis…”
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