Search Results - "Lagas, J S"

The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential by Kfoury-Beaumont, N, Prakasam, R, Pondugula, S, Lagas, J S, Matkovich, S, Gontarz, P, Yang, L, Yano, H, Kim, A H, Rubin, J B, Kroll, K L

“…Neurodevelopmental disorders increase brain tumor risk, suggesting that normal brain development may have protective properties. Mutations in epigenetic…”
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Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation by Hendrikx, J J M A, Lagas, J S, Wagenaar, E, Rosing, H, Schellens, J H M, Beijnen, J H, Schinkel, A H

“…Background: The intestinal uptake of the taxanes paclitaxel and docetaxel is seriously hampered by drug efflux through P-glycoprotein (P-gp) and drug…”
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Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice by Vlaming, M L H, Mohrmann, K, Wagenaar, E, de Waart, D R, Elferink, R P J Oude, Lagas, J S, van Tellingen, O, Vainchtein, L D, Rosing, H, Beijnen, J H, Schellens, J H M, Schinkel, A H

“…The ATP-binding-cassette (ABC) transporter multidrug resistance protein (MRP) 2 (ABCC2) forms a natural barrier and efflux system for various (conjugates of)…”
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Pharmacokinetic Assessment of Multiple ATP-binding Cassette Transporters: The Power of Combination Knockout Mice by Lagas, Jurjen S, Vlaming, Maria L H, Schinkel, Alfred H

“…A TP-binding cassette (ABC) multidrug transporters are cellular efflux pumps with broad and often widely overlapping substrate specificities. They can have a…”
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Individual and combined roles of CYP3A, P‐glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel by van Waterschoot, Robert A.B., Lagas, Jurjen S., Wagenaar, Els, Rosing, Hilde, Beijnen, Jos H., Schinkel, Alfred H.

“…Docetaxel is one of the most widely used anticancer drugs. A major problem with docetaxel treatment, however, is the considerable interpatient variability in…”
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Lethal morphine intoxication in a patient with a sickle cell crisis and renal impairment: case report and a review of the literature by Lagas, Jurjen S, Wagenaar, Jiri F P, Huitema, Alwin D R, Hillebrand, Michel J X, Koks, Cornelis H W, Gerdes, Victor E A, Brandjes, Desiderius P M, Beijnen, Jos H

“…Morphine-6-glucuronide, the active metabolite of morphine, and to a lesser extent morphine itself are known to accumulate in patients with renal failure. A…”
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