Search Results - "Lagal, Daniel J."

Protocol to identify and isolate rare murine tumor-resident dendritic cell populations for low-input transcriptomic profiling by Papadas, Athanasios, Lagal, Daniel J., Dou, Yaling, Hong, Duncan, Gibbons, Alicia, Cicala, Alexander, Huang, Yun, Zomalan, Brolyn, Molina, Elsa, Asimakopoulos, Fotis

“…Conventional type 1 dendritic cells (cDC1s) are critical for innate sensing of cancer, yet they are scarce in the tumor microenvironment (TME). Here, we…”
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Tumoral Malignancy Decreases Coupled with Higher ROS and Lipid Peroxidation in HCT116 Colon Cancer Cells upon Loss of PRDX6 by Lagal, Daniel J, Montes-Osuna, Antonio M, Ortiz-Olivencia, Alberto, Arribas-Parejas, Candela, Ortiz-Alcántara, Ángel, Pescuezo-Castillo, Cristina, Bárcena, José Antonio, Padilla, Carmen Alicia, Requejo-Aguilar, Raquel

“…Peroxiredoxin 6 (PRDX6) is an atypical member of the peroxiredoxin family that presents not only peroxidase but also phospholipase A2 and…”
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NOX1 and PRDX6 synergistically support migration and invasiveness of hepatocellular carcinoma cells through enhanced NADPH oxidase activity by Lagal, Daniel J., Bárcena, J. Antonio, Requejo-Aguilar, Raquel, Padilla, C. Alicia, Leto, Thomas L.

“…•NOX1 activity promotes hallmarks of metastasis including cell migration and invasion.•PRDX6 contributes to these pro-metastatic pathways through direct…”
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Loss of PRDX6 Aborts Proliferative and Migratory Signaling in Hepatocarcinoma Cell Lines by Lagal, Daniel J, López-Grueso, María J, Pedrajas, José R, Leto, Thomas L, Bárcena, J Antonio, Requejo-Aguilar, Raquel, Padilla, C Alicia

“…Peroxiredoxin 6 (PRDX6), the only mammalian 1-Cys member of the peroxiredoxin family, has peroxidase, phospholipase A2 (PLA2), and lysophosphatidylcholine…”
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Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity by Papadas, Athanasios, Huang, Yun, Cicala, Alexander, Dou, Yaling, Fields, Matteo, Gibbons, Alicia, Hong, Duncan, Lagal, Daniel J, Quintana, Victoria, Rizo, Alejandro, Zomalan, Brolyn, Asimakopoulos, Fotis

“…Advances in immunotherapy in the last decade have revolutionized treatment paradigms across multiple cancer diagnoses. However, only a minority of patients…”
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Abstract 4210: Stromal remodeling danger signals regulate “second-touch” antigenic encounters and promote CD8+ T cell effector differentiation in the TME by Papadas, Athanasios, Hong, Duncan, Cicala, Alexander, Gibbons, Alicia, Lagal, Daniel J., Huang, Yun, Dou, Yaling, Asimakopoulos, Fotis

“…Tumor immune infiltration (“hot” tumor microenvironment, TME) constitutes a powerful predictor of outcomes and immunotherapy efficacy, however underlying…”
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