Search Results - "Lagacé, Monique"

Combining resonance energy transfer methods reveals a complex between the α₂A-adrenergic receptor, Gαi₁β₁γ₂, and GRK2 by Breton, Billy, Lagacé, Monique, Bouvier, Michel

“…Traditionally, G-protein-coupled receptor (GPCR) interactions with their G proteins and regulatory proteins, GPCR kinases (GRKs) and arrestins, are described…”
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Homodimerization of the β2-Adrenergic Receptor as a Prerequisite for Cell Surface Targeting by Salahpour, Ali, Angers, Stéphane, Mercier, Jean-François, Lagacé, Monique, Marullo, Stefano, Bouvier, Michel

“…Although homodimerization has been demonstrated for a large number of G protein-coupled receptors (GPCRs), no general role has been attributed to this process…”
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Functional Rescue of the Constitutively Internalized V2 Vasopressin Receptor Mutant R137H by the Pharmacological Chaperone Action of SR49059 by Bernier, Virginie, Lagacé, Monique, Lonergan, Michèle, Arthus, Marie-Françoise, Bichet, Daniel G, Bouvier, Michel

“…In most cases, nephrogenic diabetes insipidus results from mutations in the V2 vasopressin receptor (V2R) gene that cause intracellular retention of improperly…”
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Protein‐protein interactions monitored in cells from transgenic mice using bioluminescence resonance energy transfer by Audet, Martin, Lagacé, Monique, Silversides, David W., Bouvier, Michel

“…ABSTRACTMonitoring the dynamics of protein‐protein interactions in their natural environment remains a challenge. Resonance energy transfer approaches…”
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Pharmacological chaperones: potential treatment for conformational diseases by Bernier, Virginie, Lagacé, Monique, Bichet, Daniel G, Bouvier, Michel

“…Increasing numbers of inherited diseases are found to result from mutations that lead to misfolded proteins. In many cases, the changes in conformation are…”
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The gene product of the gp78/AMFR ubiquitin E3 ligase cDNA is selectively recognized by the 3F3A antibody within a subdomain of the endoplasmic reticulum by Registre, Marilyn, Goetz, Jacky G., St. Pierre, Pascal, Pang, Hao, Lagacé, Monique, Bouvier, Michel, Le, Phuong U., Nabi, Ivan R.

“…The receptor for the autocrine motility factor/phosphoglucose isomerase cytokine (gp78 or AMFR) has been extensively characterized using the 3F3A monoclonal…”
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Hetero-oligomerization between β2- and β3-Adrenergic Receptors Generates a β-Adrenergic Signaling Unit with Distinct Functional Properties by Breit, Andreas, Lagacé, Monique, Bouvier, Michel

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Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR by Lukasheva, Viktoriya, Devost, Dominic, Le Gouill, Christian, Namkung, Yoon, Martin, Ryan D., Longpré, Jean-Michel, Amraei, Mohammad, Shinjo, Yuji, Hogue, Mireille, Lagacé, Monique, Breton, Billy, Aoki, Junken, Tanny, Jason C., Laporte, Stéphane A., Pineyro, Graciela, Inoue, Asuka, Bouvier, Michel, Hébert, Terence E.

“…A comprehensive understanding of signalling downstream of GPCRs requires a broad approach to capture novel signalling modalities in addition to established…”
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The palmitoylation state of the β2‐adrenergic receptor regulates the synergistic action of cyclic AMP‐dependent protein kinase and β‐adrenergic receptor kinase involved in its phosphorylation and desensitization by Moffett, Serge, Rousseau, Guy, Lagacé, Monique, Bouvier, Michel

“…Although palmitoylation of the β2‐adrenergic receptor (β2AR), as well as its phosphorylation by the cyclic AMP‐dependant protein kinase (PKA) and the…”
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Combining resonance energy transfer methods reveals a complex between the α 2A ‐adrenergic receptor, Gα i1 β 1 γ 2 , and GRK2 by Breton, Billy, Lagacé, Monique, Bouvier, Michel

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Combining resonance energy transfer methods reveals a complex between the α2A‐adrenergic receptor, Gαi1β1γ2, and GRK2 by Breton, Billy, Lagacé, Monique, Bouvier, Michel

“…ABSTRACT Traditionally, G‐protein‐coupled receptor (GPCR) interactions with their G proteins and regulatory proteins, GPCR kinases (GRKs) and ar‐restins, are…”
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The carbamyl phosphate synthetase promoter contains multiple binding sites for C/EBP-related proteins by Lagacé, M, Goping, I S, Mueller, C R, Lazzaro, M, Shore, G C

“…The promoter of the gene (CPS) encoding rat carbamyl phosphate synthetase I has been mapped 5' to a segment of about 525 nucleotides upstream from the…”
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Signal profiling of the β 1 AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β 1 AR and β 2 AR by Lukasheva, Viktoriya, Devost, Dominic, Le Gouill, Christian, Namkung, Yoon, Martin, Ryan D, Longpré, Jean-Michel, Amraei, Mohammad, Shinjo, Yuji, Hogue, Mireille, Lagacé, Monique, Breton, Billy, Aoki, Junken, Tanny, Jason C, Laporte, Stéphane A, Pineyro, Graciela, Inoue, Asuka, Bouvier, Michel, Hébert, Terence E

“…A comprehensive understanding of signalling downstream of GPCRs requires a broad approach to capture novel signalling modalities in addition to established…”
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Combining resonance energy transfer methods reveals a complex between the alpha2A-adrenergic receptor, Galphai1beta1gamma2, and GRK2 by Breton, Billy, Lagacé, Monique, Bouvier, Michel

“…Traditionally, G-protein-coupled receptor (GPCR) interactions with their G proteins and regulatory proteins, GPCR kinases (GRKs) and arrestins, are described…”
Get full text

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties by Breit, Andreas, Lagacé, Monique, Bouvier, Michel

“…The ability of the closely related beta(2)- and beta(3)-adrenergic receptors (AR) to form hetero-oligomers was assessed by bioluminescence resonance energy…”
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Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling by Breit, Andreas, Gagnidze, Khatuna, Devi, Lakshmi A, Lagacé, Monique, Bouvier, Michel

“…Hetero-oligomerization among G protein-coupled receptors has been proposed to contribute to signal integration. Because sensory neuron-specific receptors…”
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Homodimerization of the beta 2-Adrenergic Receptor as a Prerequisite for Cell Surface Targeting by Salahpour, Ali, Angers, Stephane, Mercier, Jean-Francois, Lagace, Monique, Marullo, Stefano, Bouvier, Michel

“…Although homodimerization has been demonstrated for a large number of G protein-coupled receptors (GPCRs), no general role has been attributed to this process…”
Get full text

Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting by Salahpour, Ali, Angers, Stéphane, Mercier, Jean-François, Lagacé, Monique, Marullo, Stefano, Bouvier, Michel

“…Although homodimerization has been demonstrated for a large number of G protein-coupled receptors (GPCRs), no general role has been attributed to this process…”
Get full text

The palmitoylation state of the β 2 ‐adrenergic receptor regulates the synergistic action of cyclic AMP‐dependent protein kinase and β‐adrenergic receptor kinase involved in its phosphorylation and desensitization by Moffett, Serge, Rousseau, Guy, Lagacé, Monique, Bouvier, Michel

“…Although palmitoylation of the β 2 ‐adrenergic receptor (β 2 AR), as well as its phosphorylation by the cyclic AMP‐dependant protein kinase (PKA) and the…”
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Activation of the β2-Adrenergic Receptor-Gαs Complex Leads to Rapid Depalmitoylation and Inhibition of Repalmitoylation of Both the Receptor and Gαs by Loisel, Thomas P., Ansanay, Hervé, Adam, Lynda, Marullo, Stefano, Seifert, Roland, Lagacé, Monique, Bouvier, Michel

“…Palmitoylation is unique among lipid modifications in that it is reversible. In recent years, dynamic palmitoylation of G protein α subunits and of their…”
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