Search Results - "Lafleur, Marc A."

Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis by Lafleur, Marc A, Xu, Daosong, Hemler, Martin E

“…Membrane type-1 matrix metalloproteinase (MT1-MMP) supports tumor cell invasion through extracellular matrix barriers containing fibrin, collagen, fibronectin,…”
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MRGPRX2 activation as a rapid, high-throughput mechanistic-based approach for detecting peptide-mediated human mast cell degranulation liabilities by Lafleur, Marc A., Werner, Jonathan, Fort, Madeline, Lobenhofer, Edward K., Balazs, Mercedesz, Goyos, Ana

“…Mast cells play key roles in allergy, anaphylaxis/anaphylactoid reactions, and defense against pathogens/toxins. These cells contain cytoplasmic granules with…”
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Reversible transdifferentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro by Cooley, Lindsay S, Handsley, Madeleine M, Zhou, Zhigang, Lafleur, Marc A, Pennington, Caroline J, Thompson, Erik W, Pöschl, Ernst, Edwards, Dylan R

“…Blood vascular cells and lymphatic endothelial cells (BECs and LECs, respectively) form two separate vascular systems and are functionally distinct cell types…”
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High threshold of β1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase (MT1-MMP) activation of matrix metalloproteinase 2 (MMP-2) by Borrirukwanit, Kulrut, Pavasant, Prasit, Blick, Tony, Lafleur, Marc A, Thompson, Erik W

“…Matrix metalloproteinase-2 (MMP-2) is an endopeptidase that facilitates extracellular matrix remodeling and molecular regulation, and is implicated in tumor…”
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Glioblastoma Inhibition by Cell Surface Immunoglobulin Protein EWI-2, In Vitro and In Vivo by Kolesnikova, Tatiana V., Kazarov, Alexander R., Lemieux, Madeleine E., Lafleur, Marc A., Kesari, Santosh, Kung, Andrew L., Hemler, Martin E.

“…EWI-2, a cell surface IgSF protein, is highly expressed in normal human brain but is considerably diminished in glioblastoma tumors and cell lines. Moreover,…”
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Type I Collagen Abrogates the Clathrin-mediated Internalization of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) via the MT1-MMP Hemopexin Domain by Lafleur, Marc A., Mercuri, Francesca A., Ruangpanit, Neeracha, Seiki, Motoharu, Sato, Hiroshi, Thompson, Erik W.

“…Type I collagen (Col I)-stimulated matrix metalloproteinase-2 (MMP-2) activation via membrane type 1 MMP (MT1-MMP) involves both a transcriptional increase in…”
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Selective involvement of TIMP-2 in the second activational cleavage of pro-MMP-2: refinement of the pro-MMP-2 activation mechanism by Lafleur, Marc A, Tester, Angus M, Thompson, Erik W

“…A tissue inhibitor of metalloproteinases-2 (TIMP-2)-independent mechanism for generating the first activational cleavage of pro-matrix metalloproteinase-2…”
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Xenobiotic Perturbation of ER Stress and the Unfolded Protein Response by Lafleur, Marc A., Stevens, James L., Lawrence, Jeffrey W.

“…The proper folding, assembly, and maintenance of cellular proteins is a highly regulated process and is critical for cellular homeostasis. Multiple cellular…”
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Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs) by Lafleur, Marc A, Handsley, Madeleine M, Knäuper, Vera, Murphy, Gillian, Edwards, Dylan R

“…Macro- and microvascular endothelial cells (EC) formed tubular structures when cultured within a 3D fibrin matrix, a process that was enhanced by vascular…”
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Metalloproteinases and their inhibitors in angiogenesis by Lafleur, Marc A, Handsley, Madeleine M, Edwards, Dylan R

“…Angiogenesis, the formation of new blood vessels from the pre-existing vasculature, is an integral part of physiological processes such as embryonic…”
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Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts: A major induction of stromal MMP‐13 by Lafleur, Marc A., Drew, Angela F., de Sousa, Emma L., Blick, Tony, Bills, Margaret, Walker, Emma C., Williams, Elizabeth D., Waltham, Mark, Thompson, Erik W.

“…In human breast cancer (HBC), as with many carcinoma systems, most matrix metalloproteinases (MMPs) are largely expressed by the stromal cells, whereas the…”
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Reversible transdifferentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro by Cooley, Lindsay S., Handsley, Madeleine M., Zhou, Zhigang, Lafleur, Marc A., Pennington, Caroline J., Thompson, Erik W., Pöschl, Ernst, Edwards, Dylan R.

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Perivascular Cells Regulate Endothelial Membrane Type-1 Matrix Metalloproteinase Activity by Lafleur, Marc A., Forsyth, Peter A., Atkinson, Susan J., Murphy, Gillian, Edwards, Dylan R.

“…Angiogenic stimuli selectively induced expression of membrane type-1 matrix metalloproteinase (MT1-MMP) transcripts and protein in human umbilical vein…”
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Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species by LAFLEUR, Marc A., HOLLENBERG, Morley D., ATKINSON, Susan J., KNÄUPER, Vera, MURPHY, Gillian, EDWARDS, Dylan R.

“…Thrombin, a critical enzyme in the coagulation cascade, has also been associated with angiogenesis and activation of the zymogen form of matrix…”
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High threshold of [beta]1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase (MT1-MMP) activation of matrix metalloproteinase 2 (MMP-2) by Borrirukwanit, Kulrut, Pavasant, Prasit, Blick, Tony, Lafleur, Marc A, Thompson, Erik W

“…Doc number: 99 Abstract Background: Matrix metalloproteinase-2 (MMP-2) is an endopeptidase that facilitates extracellular matrix remodeling and molecular…”
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The type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by αVβ3 integrin in human breast cancer cells by Borrirukwanit, Kulrut, Lafleur, Marc A., Mercuri, Francesca A., Blick, Tony, Price, John T., Fridman, Rafael, Pereira, Joseph J., Leardkamonkarn, Vijittra, Thompson, Erik W.

“…The influence of αVβ3 integrin on MT1-MMP functionality was studied in human breast cancer cells of differing β3 integrin status. Overexpression of β3 integrin…”
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Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species by Lafleur, M A, Hollenberg, M D, Atkinson, S J, Knäuper, V, Murphy, G, Edwards, D R

“…Thrombin, a critical enzyme in the coagulation cascade, has also been associated with angiogenesis and activation of the zymogen form of matrix…”
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Glioblastoma Inhibition by Cell Surface Immunoglobulin Protein EWI-2, In Vitro and In Vivo1,2 by Kolesnikova, Tatiana V, Kazarov, Alexander R, Lemieux, Madeleine E, Lafleur, Marc A, Kesari, Santosh, Kung, Andrew L, Hemler, Martin E

“…EWI-2, a cell surface IgSF protein, is highly expressed in normal human brain but is considerably diminished in glioblastoma tumors and cell lines. Moreover,…”
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The type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells by Borrirukwanit, Kulrut, Lafleur, Marc A, Mercuri, Francesca A, Blick, Tony, Price, John T, Fridman, Rafael, Pereira, Joseph J, Leardkamonkarn, Vijittra, Thompson, Erik W

“…The influence of alphaVbeta3 integrin on MT1-MMP functionality was studied in human breast cancer cells of differing beta3 integrin status. Overexpression of…”
Get full text