Search Results - "Laffray, Sophie"

Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis by Ferrini, Francesco, Trang, Tuan, Mattioli, Theresa-Alexandra M, Laffray, Sophie, Del'Guidice, Thomas, Lorenzo, Louis-Etienne, Castonguay, Annie, Doyon, Nicolas, Zhang, Wenbo, Godin, Antoine G, Mohr, Daniela, Beggs, Simon, Vandal, Karen, Beaulieu, Jean-Martin, Cahill, Catherine M, Salter, Michael W, De Koninck, Yves

“…Treatment of pain with morphine leads to paradoxical hyperalgesia. The authors provide evidence that morphine-induced hyperalgesia is a result of…”
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The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function by François, Amaury, Schüetter, Niklas, Laffray, Sophie, Sanguesa, Juan, Pizzoccaro, Anne, Dubel, Stefan, Mantilleri, Annabelle, Nargeot, Joel, Noël, Jacques, Wood, John N., Moqrich, Aziz, Pongs, Olaf, Bourinet, Emmanuel

“…The T-type calcium channel Cav3.2 emerges as a key regulator of sensory functions, but its expression pattern within primary afferent neurons and its…”
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Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain by Fayad, Sophie L, Ourties, Guillaume, Le Gac, Benjamin, Jouffre, Baptiste, Lamoine, Sylvain, Fruquière, Antoine, Laffray, Sophie, Gasmi, Laila, Cauli, Bruno, Mallet, Christophe, Bourinet, Emmanuel, Bessaih, Thomas, Lambert, Régis C, Leresche, Nathalie

“…Cav3.2 T-type calcium channel is a major molecular actor of neuropathic pain in peripheral sensory neurons, but its involvement at the supraspinal level is…”
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Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons by Candelas, Miriam, Reynders, Ana, Arango-Lievano, Margarita, Neumayer, Christoph, Fruquière, Antoine, Demes, Elsa, Hamid, Jawed, Lemmers, Céline, Bernat, Claire, Monteil, Arnaud, Compan, Vincent, Laffray, Sophie, Inquimbert, Perrine, Le Feuvre, Yves, Zamponi, Gerald W., Moqrich, Aziz, Bourinet, Emmanuel, Méry, Pierre-François

“…The T-type calcium channel, Cav3.2, is necessary for acute pain perception, as well as mechanical and cold allodynia in mice. Being found throughout sensory…”
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Transcriptional Profiling of Cutaneous MRGPRD Free Nerve Endings and C-LTMRs by Reynders, Ana, Mantilleri, Annabelle, Malapert, Pascale, Rialle, Stéphanie, Nidelet, Sabine, Laffray, Sophie, Beurrier, Corinne, Bourinet, Emmanuel, Moqrich, Aziz

“…Cutaneous C-unmyelinated MRGPRD+ free nerve endings and C-LTMRs innervating hair follicles convey two opposite aspects of touch sensation: a sensation of pain…”
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Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor by Vilar, Bruno, Busserolles, Jérôme, Ling, Bing, Laffray, Sophie, Ulmann, Lauriane, Malhaire, Fanny, Chapuy, Eric, Aissouni, Youssef, Etienne, Monique, Bourinet, Emmanuel, Acher, Francine, Pin, Jean-Philippe, Eschalier, Alain, Goudet, Cyril

“…Hyperactivity of the glutamatergic system is involved in the development of central sensitization in the pain neuraxis, associated with allodynia and…”
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Adaptive movement compensation for in vivo imaging of fast cellular dynamics within a moving tissue by Laffray, Sophie, Pagès, Stéphane, Dufour, Hugues, De Koninck, Paul, De Koninck, Yves, Côté, Daniel

“…In vivo non-linear optical microscopy has been essential to advance our knowledge of how intact biological systems work. It has been particularly enabling to…”
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Dissociation and trafficking of rat GABAB receptor heterodimer upon chronic capsaicin stimulation by Laffray, Sophie, Tan, Kelly, Dulluc, Josette, Bouali-Benazzouz, Rabia, Calver, Andrew R., Nagy, Frédéric, Landry, Marc

“…Gamma‐aminobutyric acid type B receptors (GABAB) are G‐protein‐coupled receptors that mediate GABAergic inhibition in the brain. Their functional expression is…”
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T-type calcium channels in neuropathic pain by Bourinet, Emmanuel, Francois, Amaury, Laffray, Sophie

“…Pain is a quite frequent complaint accompanying numerous pathologies. Among these pathological cases, numerous neuropathies are retrieved with identified…”
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T-type calcium channels in chronic pain: mouse models and specific blockers by François, Amaury, Laffray, Sophie, Pizzoccaro, Anne, Eschalier, Alain, Bourinet, Emmanuel

“…Pain is a quite frequent complaint accompanying numerous pathologies. Among these pathological cases, neuropathies are retrieved with identified etiologies…”
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T-type calcium channel Cav3.2 deficient mice show elevated anxiety, impaired memory and reduced sensitivity to psychostimulants by Gangarossa, Giuseppe, Laffray, Sophie, Bourinet, Emmanuel, Valjent, Emmanuel

“…The fine-tuning of neuronal excitability relies on a tight control of Ca(2+) homeostasis. The low voltage-activated (LVA) T-type calcium channels (Cav3.1,…”
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Fxyd2 regulates Aδ- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain by Ventéo, Stéphanie, Laffray, Sophie, Wetzel, Christiane, Rivat, Cyril, Scamps, Frédérique, Méchaly, Ilana, Bauchet, Luc, Raoul, Cédric, Bourinet, Emmanuel, Lewin, Gary R., Carroll, Patrick, Pattyn, Alexandre

“…Identification of the molecular mechanisms governing sensory neuron subtype excitability is a key requisite for the development of treatments for somatic…”
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Impairment of GABAB receptor dimer by endogenous 14-3-3ζ in chronic pain conditions by Laffray, Sophie, Bouali-Benazzouz, Rabia, Papon, Marie-Amélie, Favereaux, Alexandre, Jiang, Yang, Holm, Tina, Spriet, Corentin, Desbarats, Pascal, Fossat, Pascal, Le Feuvre, Yves, Decossas, Marion, Héliot, Laurent, Langel, Ulo, Nagy, Frédéric, Landry, Marc

“…In the central nervous system, the inhibitory GABAB receptor is the archetype of heterodimeric G protein‐coupled receptors (GPCRs). However, the regulation of…”
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Automated method for the segmentation and morphometry of nerve fibers in large-scale CARS images of spinal cord tissue by Bégin, Steve, Dupont-Therrien, Olivier, Bélanger, Erik, Daradich, Amy, Laffray, Sophie, De Koninck, Yves, Côté, Daniel C

“…A fully automated method for large-scale segmentation of nerve fibers from coherent anti-Stokes Raman scattering (CARS) microscopy images is presented. The…”
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Live animal myelin histomorphometry of the spinal cord with video-rate multimodal nonlinear microendoscopy by Be´langer, Erik, Cre´peau, Joe¨l, Laffray, Sophie, Valle´e, Re´al, De Koninck, Yves, Coˆte´, Daniel

“…imaging of cellular dynamics can be dramatically enabling to understand the pathophysiology of nervous system diseases. To fully exploit the power of this…”
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Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain by Fayad, Sophie, Ourties, Guillaume, Le Gac, Benjamin, Jouffre, Baptiste, Lamoine, Sylvain, Fruquière, Antoine, Laffray, Sophie, Gasmi, Laila, Cauli, Bruno, Mallet, Christophe, Bourinet, Emmanuel, Bessaih, Thomas, Lambert, Régis, Leresche, Nathalie

“…Cav3.2 T-type calcium channel is a major molecular actor of neuropathic pain in peripheral sensory neurons, but its involvement at the supraspinal level is…”
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Fxyd2 regulates Adelta- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain by Venteo, Stéphanie, Laffray, Sophie, Wetzel, Christiane, Rivat, Cyril, Scamps, Frédérique, Mechaly, Ilana, Bauchet, Luc, Raoul, Cedric, Bourinet, Emmanuel, Lewin, Gary R., Carroll, Patrick, Pattyn, Alexandre

“…Identification of the molecular mechanisms governing sensory neuron subtype excitability is a key requisite for the development of treatments for somatic…”
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Transcriptional Profiling of Cutaneous MRGPRD Free Nerve Endings and C-LTMRs by Reynders, Ana, Mantilleri, Annabelle, Malapert, Pascale, Rialle, Stéphanie, Nidelet, Sabine, Laffray, Sophie, Beurrier, Corinne, Bourinet, Emmanuel, Moqrich, Aziz

“…Highlights d GINIP and IB4 staining segregate DRG neurons in four distinct subpopulations d MRGPRD + free nerve endings and C-LTRMs display distinct…”
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In vivo optical monitoring of tissue pathologies and diseases with vibrational contrast by Bégin, Steve, Bélanger, Erik, Laffray, Sophie, Vallée, Réal, Côté, Daniel

“…Studies of tissue remodeling require in vivo imaging techniques that are as minimally invasive as possible to avoid microenvironment perturbations. To this…”
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Local assessment of myelin health in a multiple sclerosis mouse model using a 2D Fourier transform approach by Bégin, Steve, Bélanger, Erik, Laffray, Sophie, Aubé, Benoît, Chamma, Emilie, Bélisle, Jonathan, Lacroix, Steve, De Koninck, Yves, Côté, Daniel

“…We present an automated two-dimensional Fourier transform (2D-FT) approach to analyze the local organization of myelinated axons in the spinal cord. Coherent…”
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