Search Results - "Laffer, Cheryl L."

Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association by Carey, Robert M, Calhoun, David A, Bakris, George L, Brook, Robert D, Daugherty, Stacie L, Dennison-Himmelfarb, Cheryl R, Egan, Brent M, Flack, John M, Gidding, Samuel S, Judd, Eric, Lackland, Daniel T, Laffer, Cheryl L, Newton-Cheh, Christopher, Smith, Steven M, Taler, Sandra J, Textor, Stephen C, Turan, Tanya N, White, William B

“…Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a patient despite the concurrent use of 3 antihypertensive drug classes,…”
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Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide by Loperena, Roxana, Van Beusecum, Justin P, Itani, Hana A, Engel, Noah, Laroumanie, Fanny, Xiao, Liang, Elijovich, Fernando, Laffer, Cheryl L, Gnecco, Juan S, Noonan, Jonathan, Maffia, Pasquale, Jasiewicz-Honkisz, Barbara, Czesnikiewicz-Guzik, Marta, Mikolajczyk, Tomasz, Sliwa, Tomasz, Dikalov, Sergey, Weyand, Cornelia M, Guzik, Tomasz J, Harrison, David G

“…Abstract Aims Monocytes play an important role in hypertension. Circulating monocytes in humans exist as classical, intermediate, and non-classical forms…”
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In Memoriam: Fernando Elijovich by Ertuglu, Lale A., Laffer, Cheryl L., Kirabo, Annet

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Hemodynamics and Salt-and-Water Balance Link Sodium Storage and Vascular Dysfunction in Salt-Sensitive Subjects by Laffer, Cheryl L, Scott, Robert C, Titze, Jens M, Luft, Friedrich C, Elijovich, Fernando

“…We investigated 24-hour hemodynamic changes produced by salt loading and depletion in 8 salt-sensitive (SS) and 13 salt-resistant (SR) normotensive volunteers…”
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Salt-Sensitivity of Blood Pressure and Insulin Resistance by Ertuglu, Lale A, Elijovich, Fernando, Laffer, Cheryl L, Kirabo, Annet

“…Salt sensitivity of blood pressure (SSBP) is an independent risk factor for cardiovascular morbidity and mortality that is seen in both hypertensive and…”
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Regulation of human salt-sensitivite hypertension by myeloid cell renin-angiotensin-aldosterone system by Ertuglu, Lale A, Pitzer Mutchler, Ashley, Elijovich, Fernando, Laffer, Cheryl L, Sheng, Quanhu, Wanjalla, Celestine N, Kirabo, Annet

“…Salt sensitivity of blood pressure is a phenomenon in which blood pressure changes according to dietary sodium intake. Our previous studies found that high…”
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Salt Sensitivity of Blood Pressure in Black People: The Need to Sort Out Ancestry Versus Epigenetic Versus Social Determinants of Its Causation by Elijovich, Fernando, Kirabo, Annet, Laffer, Cheryl L

“…Race is a social construct, but self-identified Black people are known to have higher prevalence and worse outcomes of hypertension than White people. This may…”
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Effects of carotid body tumor resection on the blood pressure of essential hypertensive patients by Fudim, Marat, Groom, Kelly L, Laffer, Cheryl L, Netterville, James L, Robertson, David, Elijovich, Fernando

“…Removal of carotid body (CB) improves animal models of hypertension (HTN) and heart failure, via withdrawal of chemoreflex-induced sympathetic activation…”
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Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans by Laffer, Cheryl L, Elijovich, Fernando, Eckert, George J, Tu, Wanzhu, Pratt, J Howard, Brown, Nancy J

“…An rs3890011 variant of CYP4A11, which is in linkage disequilibrium with the loss-of-function variant rs1126742, is associated with hypertension in humans. In…”
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The T8590C Polymorphism of CYP4A11 and 20-Hydroxyeicosatetraenoic Acid in Essential Hypertension by Laffer, Cheryl L, Gainer, James V, Waterman, Michael R, Capdevila, Jorge H, Laniado-Schwartzman, Michal, Nasjletti, Alberto, Brown, Nancy J, Elijovich, Fernando

“…A role for a deficit in transport actions of 20-hydroxyeicosatetraenoic acid (20-HETE) in hypertension is supported by the following(1) diminished renal…”
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Immune Mechanisms of Dietary Salt-Induced Hypertension and Kidney Disease: Harry Goldblatt Award for Early Career Investigators 2020 by Elijovich, Fernando, Kleyman, Thomas R., Laffer, Cheryl L., Kirabo, Annet

“…Salt sensitivity of blood pressure is an independent risk factor for cardiovascular mortality not only in hypertensive but also in normotensive adults. The…”
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Is Clonidine Contraindicated for the Treatment of Hypertensive Urgencies in Hospitalized Patients? by Laffer, Cheryl L, Elijovich, Fernando

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Patient Stratification Using Electronic Health Records from a Chronic Disease Management Program by Chen, Robert, Sun, Jimeng, Dittus, Robert S., Fabbri, Daniel, Kirby, Jacqueline, Laffer, Cheryl L., McNaughton, Candace D., Malin, Bradley

“…Objective: The goal of this study is to devise a machine learning framework to assist care coordination programs in prognostic stratification to design and…”
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What Kind of Evidence Is Needed to Dictate Practice Regarding Inhibitors of the Renin-Angiotensin System in COVID-19? by Elijovich, Fernando, Laffer, Cheryl L.

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Salt Sensitivity of Blood Pressure: A Scientific Statement From the American Heart Association by Elijovich, Fernando, Weinberger, Myron H, Anderson, Cheryl A.M, Appel, Lawrence J, Bursztyn, Michael, Cook, Nancy R, Dart, Richard A, Newton-Cheh, Christopher H, Sacks, Frank M, Laffer, Cheryl L

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Hypertension: Do Inflammation and Immunity Hold the Key to Solving this Epidemic? by Madhur, Meena S., Elijovich, Fernando, Alexander, Matthew R., Pitzer, Ashley, Ishimwe, Jeanne, Van Beusecum, Justin P., Patrick, David M., Smart, Charles D., Kleyman, Thomas R., Kingery, Justin, Peck, Robert N., Laffer, Cheryl L., Kirabo, Annet

“…Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even after normalization of blood pressure in patients with…”
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New Insights Into the Renin-Angiotensin System in Chronic Kidney Disease by Laffer, Cheryl L., Elijovich, Fernando, Sahinoz, Melis, Pitzer, Ashley, Kirabo, Annet

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Recent advances in modulation of cardiovascular diseases by the gut microbiota by Masenga, Sepiso K., Hamooya, Benson, Hangoma, Joy, Hayumbu, Valerie, Ertuglu, Lale A., Ishimwe, Jeanne, Rahman, Sharla, Saleem, Mohammad, Laffer, Cheryl L., Elijovich, Fernando, Kirabo, Annet

“…The gut microbiota has recently gained attention due to its association with cardiovascular health, cancers, gastrointestinal disorders, and non-communicable…”
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DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension by Pitzer, Ashley, Elijovich, Fernando, Laffer, Cheryl L., Ertuglu, Lale A., Sahinoz, Melis, Saleem, Mohammad, Krishnan, Jaya, Dola, Thanvi, Aden, Luul A., Sheng, Quanhu, Raddatz, Michael A., Wanjalla, Celestine, Pakala, Suman, Davies, Sean S., Patrick, David M., Kon, Valentina, Ikizler, T. Alp, Kleyman, Thomas, Kirabo, Annet

“…Salt sensitivity of blood pressure is an independent predictor of cardiovascular morbidity and mortality. The exact mechanism by which salt intake increases…”
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Urinary sodium excretion measures and health outcomes by Elijovich, Fernando, Laffer, Cheryl L

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