Search Results - "Lafarga, Vanesa"

The complex G protein‐coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets by Penela, Petronila, Murga, Cristina, Ribas, Catalina, Lafarga, Vanesa, Mayor Jr, Federico

“…GRK2 is a ubiquitous member of the G protein‐coupled receptor kinase (GRK) family that appears to play a central, integrative role in signal transduction…”
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PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection by Morales, Carmen, Ruiz-Torres, Miguel, Rodríguez-Acebes, Sara, Lafarga, Vanesa, Rodríguez-Corsino, Miriam, Megías, Diego, Cisneros, David A., Peters, Jan-Michael, Méndez, Juan, Losada, Ana

“…Cohesin is a chromatin-bound complex that mediates sister chromatid cohesion and facilitates long-range interactions through DNA looping. How the transcription…”
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A novel GRK2/HDAC6 interaction modulates cell spreading and motility by Lafarga, Vanesa, Aymerich, Ivette, Tapia, Olga, Mayor Jr, Federico, Penela, Petronila

“…Cell motility and adhesion involves dynamic microtubule (MT) acetylation/deacetylation, a process regulated by enzymes as HDAC6, a major cytoplasmic α‐tubulin…”
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p38 Mitogen-Activated Protein Kinase- and HuR-Dependent Stabilization of p21Cip1 mRNA Mediates the G1/S Checkpoint by Lafarga, Vanesa, Cuadrado, Ana, Lopez de Silanes, Isabel, Bengoechea, Rocio, Fernandez-Capetillo, Oscar, Nebreda, Angel R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Decoding protein methylation function with thermal stability analysis by Sayago, Cristina, Sánchez-Wandelmer, Jana, García, Fernando, Hurtado, Begoña, Lafarga, Vanesa, Prieto, Patricia, Zarzuela, Eduardo, Ximénez-Embún, Pilar, Ortega, Sagrario, Megías, Diego, Fernández-Capetillo, Oscar, Malumbres, Marcos, Munoz, Javier

“…Protein methylation is an important modification beyond epigenetics. However, systems analyses of protein methylation lag behind compared to other…”
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Mislocalization of SMN from the I-band and M-band in human skeletal myofibers in spinal muscular atrophy associates with primary structural alterations of the sarcomere by Berciano, María T., Castillo-Iglesias, María S., Val-Bernal, J. Fernando, Lafarga, Vanesa, Rodriguez-Rey, José C., Lafarga, Miguel, Tapia, Olga

“…Spinal muscular atrophy (SMA) is caused by a deletion or mutation of the survival motor neuron 1 ( SMN1 ) gene. Reduced SMN levels lead to motor neuron…”
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A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitors by Corman, Alba, Kanellis, Dimitris C, Michalska, Patrycja, Häggblad, Maria, Lafarga, Vanesa, Bartek, Jiri, Carreras-Puigvert, Jordi, Fernandez-Capetillo, Oscar

“…We here conducted an image-based chemical screen to evaluate how medically approved drugs, as well as drugs that are currently under development, influence…”
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Nucleolin reorganization and nucleolar stress in Purkinje cells of mutant PCD mice by Baltanás, Fernando C., Berciano, María T., Tapia, Olga, Narcis, Josep Oriol, Lafarga, Vanesa, Díaz, David, Weruaga, Eduardo, Santos, Eugenio, Lafarga, Miguel

“…The Purkinje cell (PC) degeneration (pcd) mouse harbors a mutation in Agtpbp1 gene that encodes for the cytosolic carboxypeptidase, CCP1. The mutation causes…”
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G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis by Nogués, Laura, Reglero, Clara, Rivas, Verónica, Salcedo, Alicia, Lafarga, Vanesa, Neves, Maria, Ramos, Paula, Mendiola, Marta, Berjón, Alberto, Stamatakis, Kostas, Zhou, Xiao Zhen, Lu, Kun Ping, Hardisson, David, Mayor, Federico, Penela, Petronila

“…In addition to oncogenic drivers, signaling nodes can critically modulate cancer-related cellular networks to strength tumor hallmarks. We identify…”
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GRK2-mediated AKT activation controls cell cycle progression and G2 checkpoint in a p53-dependent manner by Rivas, Verónica, González-Muñoz, Teresa, Albitre, Ángela, Lafarga, Vanesa, Delgado-Arévalo, Cristina, Mayor, Federico, Penela, Petronila

“…Cell cycle checkpoints, activated by stressful events, halt the cell cycle progression, and prevent the transmission of damaged DNA. These checkpoints prompt…”
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S179: HNRNPK OVEREXPRESSION DRIVES NUCLEOLAR ABERRANCIES CAUSING RIBOSOMPATHIES by Garrido, Pedro Aguilar, Estevez, Maria Velasco, Ángel Navarro Aguadero, Miguel, Hernández Sánchez, María, Malaney, Prerna, Hornbaker, Marisa, Zhang, Xiaorui, Ibañez Navarro, Marta, Ortiz‐Ruiz, Alejandra, Otero‐Sobrino, Álvaro, Megías, Diego, Pérez, Manuel, Gómez, Jesús, Mata, Gadea, Dominguez, Orlando, Grana, Osvaldo, Caleiras, Eduardo, Isasa, Marta, Andrés, Paloma Jimena, Rodriguez, Sandra, Torres, Raúl, Sirozh, Oleksandra, Lafarga, Vanesa, Martínez‐Lopez, Joaquín, Post, Sean, Gallardo, Miguel

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p18Hamlet Mediates Different p53-Dependent Responses to DNA Damage Inducing Agents by Lafarga, Vanesa, Cuadrado, Ana, Nebreda, Angel R.

“…Cells organize appropriate responses to environmental cues by activating specific signaling networks. Two proteins that play key roles in coordinating stress…”
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Targeting the nucleolus as a therapeutic strategy in human disease by Corman, Alba, Sirozh, Oleksandra, Lafarga, Vanesa, Fernandez-Capetillo, Oscar

“…The nucleolus is the site of ribosome biogenesis, one of the most resource-intensive processes in eukaryotic cells. Accordingly, nucleolar morphology and…”
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Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation by Cuadrado, Ana, Corrado, Nadia, Perdiguero, Eusebio, Lafarga, Vanesa, Muñoz-Canoves, Pura, Nebreda, Angel R

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USP7 limits CDK1 activity throughout the cell cycle by Galarreta, Antonio, Valledor, Pablo, Ubieto‐Capella, Patricia, Lafarga, Vanesa, Zarzuela, Eduardo, Muñoz, Javier, Malumbres, Marcos, Lecona, Emilio, Fernandez‐Capetillo, Oscar

“…Chemical inhibitors of the deubiquitinase USP7 are currently being developed as anticancer agents based on their capacity to stabilize P53. Regardless of this…”
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CBP-mediated SMN acetylation modulates Cajal body biogenesis and the cytoplasmic targeting of SMN by Lafarga, Vanesa, Tapia, Olga, Sharma, Sahil, Bengoechea, Rocio, Stoecklin, Georg, Lafarga, Miguel, Berciano, Maria T.

“…The survival of motor neuron (SMN) protein plays an essential role in the biogenesis of spliceosomal snRNPs and the molecular assembly of Cajal bodies (CBs)…”
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Widespread displacement of DNA‐ and RNA‐binding factors underlies toxicity of arginine‐rich cell‐penetrating peptides by Lafarga, Vanesa, Sirozh, Oleksandra, Díaz‐López, Irene, Galarreta, Antonio, Hisaoka, Misaru, Zarzuela, Eduardo, Boskovic, Jasminka, Jovanovic, Bogdan, Fernandez‐Leiro, Rafael, Muñoz, Jaime, Stoecklin, Georg, Ventoso, Iván, Fernandez‐Capetillo, Oscar

“…Due to their capability to transport chemicals or proteins into target cells, cell‐penetrating peptides (CPPs) are being developed as therapy delivery tools…”
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Hnrnpk Overexpression Drives Nucleolar Aberrancies Causing Ribosomopathies by Aguilar-Garrido, Pedro, Velasco-Estevez, Maria, Navarro-Aguadero, Miguel Ángel, Hernández-Sánchez, María, Ibáñez-Navarro, Marta, Malaney, Prerna, Aitken, Marisa, Zhang, Xiaorui, Fernández, Adrián, Ortiz-Ruiz, Alejandra, Otero-Sobrino, Álvaro, Megías, Diego, Pérez, Manuel, Gómez, Jesús, Mata, Gadea, Domínguez, Orlando, Graña, Osvaldo, Ximénez, Pilar, Isasa, Marta, Jimena-de Andrés, Paloma, Rodríguez, Sandra, Torres, Raúl, Lafarga, Miguel, Sirozh, Oleksandra, Lafarga, Vanesa, Martinez-Lopez, Joaquin, Post, Sean M., Gallardo, Miguel

“…Background: Protein biogenesis is a complex process involving nucleoli and ribosomes. Alterations in any step could lead to alterations in ribosome…”
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USP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork by Franz, André, Valledor, Pablo, Ubieto-Capella, Patricia, Pilger, Domenic, Galarreta, Antonio, Lafarga, Vanesa, Fernández-Llorente, Alejandro, de la Vega-Barranco, Guillermo, den Brave, Fabian, Hoppe, Thorsten, Fernandez-Capetillo, Oscar, Lecona, Emilio

“…The AAA+ ATPase VCP regulates the extraction of SUMO and ubiquitin-modified DNA replication factors from chromatin. We have previously described that active…”
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The SMN Tudor SIM-like domain is key to SmD1 and coilin interactions and to Cajal body biogenesis by Tapia, Olga, Lafarga, Vanesa, Bengoechea, Rocio, Palanca, Ana, Lafarga, Miguel, Berciano, María T

“…Cajal bodies (CBs) are nuclear organelles involved in the maturation of spliceosomal small nuclear ribonucleoproteins (snRNPs). They concentrate coilin, snRNPs…”
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