Search Results - "Laduron, P"

Pharmacological Properties of a Potent and Selective Nonpeptide Substance P Antagonist by Garret, Claude, Carruette, Anne, Fardin, Veronique, Moussaoui, Saliha, Peyronel, Jean-Francois, Blanchard, Jean-Charles, Laduron, Pierre M.

“…We describe here the pharmacological properties of RP 67580 {(3aR,7aR)-7,7-diphenyl-2-[1-imino-2-(2-methoxyphenyl)ethyl] perhydroisoindol-4-one}, a nonpeptide…”
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Riluzole Series. Synthesis and in Vivo “Antiglutamate” Activity of 6-Substituted-2-benzothiazolamines and 3-Substituted-2-imino-benzothiazolines by Jimonet, Patrick, Audiau, François, Barreau, Michel, Blanchard, Jean-Charles, Boireau, Alain, Bour, Yvette, Coléno, Marie-Annick, Doble, Adam, Doerflinger, Gilles, Do Huu, Claudine, Donat, Marie-Hélène, Duchesne, Jean Marie, Ganil, Pierre, Guérémy, Claude, Honoré, Eliane, Just, Bernard, Kerphirique, Roselyne, Gontier, Sylvie, Hubert, Philippe, Laduron, Pierre M, Le Blevec, Joseph, Meunier, Mireille, Miquet, Jean-Marie, Nemecek, Conception, Pasquet, Martine, Piot, Odile, Pratt, Jeremy, Rataud, Jean, Reibaud, Michel, Stutzmann, Jean-Marie, Mignani, Serge

“…Two series of analogues of riluzole, a blocker of excitatory amino acid mediated neurotransmission, have been synthesized: monosubstituted 2-benzothiazolamines…”
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Interleukin-1β induces long-term increase of axonally transported opiate receptors and substance P by Jeanjean, A.P., Moussaoui, S.M., Maloteaux, J.-M., Laduron, P.M.

“…Interleukin-1 is known to exert pleiotropic effects in host defence mechanisms and in inflammation. Chronic pain, inflammation and interleukin-1β enhance the…”
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Riluzole, a novel antiglutamate, prevents memory loss and hippocampal neuronal damage in ischemic gerbils by Malgouris, C, Bardot, F, Daniel, M, Pellis, F, Rataud, J, Uzan, A, Blanchard, JC, Laduron, PM

“…The neuroprotective effects of riluzole, a novel antiglutamate, has been demonstrated in a model of ischemia induced in female Mongolian gerbils by transient…”
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Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonist by Leysen, J E, Gommeren, W, Van Gompel, P, Wynants, J, Janssen, P F, Laduron, P M

“…In vitro and in vivo receptor-binding properties of the new serotonin antagonist, ritanserin, are reported. In in vitro binding assays, ritanserin shows high…”
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Axonal transport of TREK and TRAAK potassium channels in rat sciatic nerves by Bearzatto, Bertrand, Lesage, Florian, Reyes, Roberto, Lazdunski, Michel, Laduron, Pierre M

“…The recent cloning, functional expression and brain localization of two new potassium channels, TREK and TRAAK, led us to examine whether both channels are…”
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Presynaptic receptors: more hetero than auto by Laduron, Pierre M

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From receptor internalization to nuclear translocation. New targets for long-term pharmacology by Laduron, P M

“…Receptors involved in intercellular communication at the cell surface share the capacity to desensitize through molecular and cellular mechanisms. Cellular…”
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Functional consequences of retrograde axonal transport of receptor-bound neurotensin by Laduron, Pierre M.

“…Transport mechanisms or trafficking systems in axons allow neuronal constituents to reach nerve terminals. Accordingly, presynaptic receptors undergo axonal…”
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Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia by Pratt, J, Rataud, J, Bardot, F, Roux, M, Blanchard, J C, Laduron, P M, Stutzmann, J M

“…Riluzole (2 amino 6-trifluoromethoxybenzothiazole), when administered at 4 and 8 mg/kg i.p., 0.5, 4.5, 24 and 28 h after the initiation of ischaemia,…”
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Distribution of neurokinin B in rat spinal cord and peripheral tissues: comparison with neurokinin A and substance P and effects of neonatal capsaicin treatment by Moussaoui, S M, Le Prado, N, Bonici, B, Faucher, D C, Cuiné, F, Laduron, P M, Garret, C

“…In the present study, highly specific radioimmunoassays were developed and used to measure neurokinin B, neurokinin A and substance P in the rat spinal cord…”
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A non‐peptide NK1‐receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically by Moussaoui, S.M., Montier, F., Carruette, A., Blanchard, J.C., Laduron, P.M., Garret, C.

“…1 The non‐peptide neurokinin NK1‐receptor antagonist, RP 67580 (3aR, 7a), a perhydroisoindolone derivative, powerfully reduced plasma extravasation in rat hind…”
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Polyclonal antibodies against the rat NK1 receptor: characterization and localization in the spinal cord by Moussaoui, S M, Hermans, E, Mathieu, A M, Bonici, B, Clerc, F, Guinet, F, Garret, C, Laduron, P M

“…We have developed antibodies against the NK1 receptor and have investigated its cellular distribution. Rabbit polyclonal antibodies were generated against…”
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Neurotensin increases tyrosine hydroxylase messenger RNA-positive neurons in substantia nigra after retrograde axonal transport by Burgevin, M C, Castel, M N, Quarteronet, D, Chevet, T, Laduron, P M

“…In previous studies we have shown that labelled neurotensin injected into the rat striatum was found to be transported retrogradely in dopaminergic neurons…”
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Ketanserin binds to the monoamine transporter of chromaffin granules and of synaptic vesicles by Darchen, F, Scherman, D, Laduron, P M, Henry, J P

“…[3H]Ketanserin binding studies were performed on purified chromaffin granule membranes. Binding was found to occur on one class of sites and was temperature…”
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Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors by Leysen, J E, Awouters, F, Kennis, L, Laduron, P M, Vandenberk, J, Janssen, P A

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Axonal transport of neuroreceptors: possible involvement in long-term memory by Laduron, P M

“…Evidence is presented that neuroreceptors move bidirectionally along axons of neurons through fast axoplasmic transport mechanisms. The retrograde transport of…”
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Retrograde axonal transport of neurotensin in the dopaminergic nigrostriatal pathway in the rat by Castel, M N, Malgouris, C, Blanchard, J C, Laduron, P M

“…Although the existence of receptor transport has been clearly demonstrated in peripheral nerves, there is no clear cut evidence in the brain of such a process…”
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Genomic pharmacology: more intracellular sites for drug action by Laduron, P M

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Evidence for a displaceable non-specific [3H]neurotensin binding site in rat brain by Schotte, A, Leysen, J E, Laduron, P M

“…Levocabastine is a potent antihistamine drug, structurally unrelated to neurotensin. In rat and mouse brain but not in other animal species, it inhibited 60%…”
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