Search Results - "Ladouceur, Gaetan H."

Discovery of 5-Hydroxyalkyl-4-phenylpyridines as a New Class of Glucagon Receptor Antagonists by Ladouceur, Gaetan H., Cook, James H., Doherty, Elizabeth M., Schoen, William R., MacDougall, Margit L., Livingston, James N.

“…5-Hydroxyalkyl-4-phenylpyridines have been identified as a novel class of glucagon antagonists with potential utility for the treatment of diabetes. A lead…”
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Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists by Ladouceur, Gaetan H., Cook, James H., Hertzog, Donald L., Jones, J.Howard, Hundertmark, Thomas, Korpusik, Mary, Lease, Timothy G., Livingston, James N., MacDougall, Margit L., Osterhout, Martin H., Phelan, Kathleen, Romero, Romulo H., Schoen, William R., Shao, Chunning, Smith, Roger A.

“…Optimized substituent patterns in 4-aryl-pyridine glucagon receptor antagonists were merged to produce highly potent derivatives containing both a 3-[(1…”
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Optimization of the 4-aryl group of 4-aryl-pyridine glucagon antagonists: development of an efficient, alternative synthesis by Smith, Roger A., Hertzog, Donald L., Osterhout, Martin H., Ladouceur, Gaetan H., Korpusik, Mary, Bobko, Mark A., Jones, J.Howard, Phelan, Kathleen, Romero, Romulo H., Hundertmark, Thomas, MacDougall, Margit L., Livingston, James N., Schoen, William R.

“…A narrow structure–activity relationship was established for the 4-aryl group in 4-aryl-pyridine glucagon antagonists, with only small substituents being…”
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4-Phenylpyridine glucagon receptor antagonists: synthetic approaches to the sterically hindered chiral hydroxy group by Ladouceur, Gaetan H., Cook, James H., Doherty, Elizabeth M., Giebel, Dierk, Schoen, William R.

“…Systematic evaluation of the structure–activity relationships of a new class of 4-aryl-pyridine glucagon antagonists led to the discovery of potent analogues…”
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