Search Results - "Ladiges, C."

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival by Ramos, Fresnida J, Chen, Steven C, Garelick, Michael G, Dai, Dao-Fu, Liao, Chen-Yu, Schreiber, Katherine H, MacKay, Vivian L, An, Elroy H, Strong, Randy, Ladiges, Warren C, Rabinovitch, Peter S, Kaeberlein, Matt, Kennedy, Brian K

“…Mutations in LMNA, the gene that encodes A-type lamins, cause multiple diseases including dystrophies of the skeletal muscle and fat, dilated cardiomyopathy,…”
Get more information

Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging by DAI, Dao-Fu, SANTANA, Luis F, RABINOVITCH, Peter S, VERMULST, Marc, TOMAZELA, Daniela M, EMOND, Mary J, MACCOSS, Michael J, GOLLAHON, Katherine, MARTIN, George M, LOEB, Lawrence A, LADIGES, Warren C

“…Age is a major risk for cardiovascular diseases. Although mitochondrial reactive oxygen species have been proposed as one of the causes of aging, their role in…”
Get full text

Measures of Healthspan as Indices of Aging in Mice-A Recommendation by Richardson, Arlan, Fischer, Kathleen E, Speakman, John R, de Cabo, Rafael, Mitchell, Sarah J, Peterson, Charlotte A, Rabinovitch, Peter, Chiao, Ying A, Taffet, George, Miller, Richard A, Rentería, René C, Bower, James, Ingram, Donald K, Ladiges, Warren C, Ikeno, Yuji, Sierra, Felipe, Austad, Steven N

“…Over the past decade, a large number of discoveries have shown that interventions (genetic, pharmacological, and nutritional) increase the lifespan of…”
Get full text

Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice by McElroy, Gregory S., Chakrabarty, Ram P., D’Alessandro, Karis B., Hu, Yuan-Shih, Vasan, Karthik, Tan, Jerica, Stoolman, Joshua S., Weinberg, Samuel E., Steinert, Elizabeth M., Reyfman, Paul A., Singer, Benjamin D., Ladiges, Warren C., Gao, Lin, Lopéz-Barneo, José, Ridge, Karen, Budinger, G. R. Scott, Chandel, Navdeep S.

“…Aging in mammals leads to reduction in genes encoding the 45-subunit mitochondrial electron transport chain complex I. It has been hypothesized that normal…”
Get full text

The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1 by O'Leary, Monique N, Schreiber, Katherine H, Zhang, Yong, Duc, Anne-Cécile E, Rao, Shuyun, Hale, J Scott, Academia, Emmeline C, Shah, Shreya R, Morton, John F, Holstein, Carly A, Martin, Dan B, Kaeberlein, Matt, Ladiges, Warren C, Fink, Pamela J, Mackay, Vivian L, Wiest, David L, Kennedy, Brian K

“…Most yeast ribosomal protein genes are duplicated and their characterization has led to hypotheses regarding the existence of specialized ribosomes with…”
Get full text

C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension by McQuary, Philip R., Liao, Chen-Yu, Chang, Jessica T., Kumsta, Caroline, She, Xingyu, Davis, Andrew, Chu, Chu-Chiao, Gelino, Sara, Gomez-Amaro, Rafael L., Petrascheck, Michael, Brill, Laurence M., Ladiges, Warren C., Kennedy, Brian K., Hansen, Malene

“…Deficiency of S6 kinase (S6K) extends the lifespan of multiple species, but the underlying mechanisms are unclear. To discover potential effectors of…”
Get full text

Canagliflozin extends life span in genetically heterogeneous male but not female mice by Miller, Richard A, Harrison, David E, Allison, David B, Bogue, Molly, Debarba, Lucas, Diaz, Vivian, Fernandez, Elizabeth, Galecki, Andrzej, Garvey, W Timothy, Jayarathne, Hashan, Kumar, Navasuja, Javors, Martin A, Ladiges, Warren C, Macchiarini, Francesca, Nelson, James, Reifsnyder, Peter, Rosenthal, Nadia A, Sadagurski, Marianna, Salmon, Adam B, Smith, Jr, Daniel L, Snyder, Jessica M, Lombard, David B, Strong, Randy

“…Canagliflozin (Cana) is an FDA-approved diabetes drug that protects against cardiovascular and kidney diseases. It also inhibits the sodium glucose transporter…”
Get full text

Exercise training in transgenic mice is associated with attenuation of early breast cancer growth in a dose-dependent manner by Goh, Jorming, Tsai, Jesse, Bammler, Theo K, Farin, Frederico M, Endicott, Emma, Ladiges, Warren C

“…Epidemiological research suggests that regular physical activity confers beneficial effects that mediate an anti-tumor response and may reduce cancer…”
Get full text

Glutamate Cysteine Ligase Modifier Subunit Deficiency and Gender as Determinants of Acetaminophen-Induced Hepatotoxicity in Mice by McConnachie, Lisa A., Mohar, Isaac, Hudson, Francesca N., Ware, Carol B., Ladiges, Warren C., Fernandez, Carolina, Chatterton-Kirchmeier, Sam, White, Collin C., Pierce, Robert H., Kavanagh, Terrance J.

“…The analgesic and antipyretic drug acetaminophen (APAP) is bioactivated to the reactive intermediate N-acetyl-p-benzoquinoneimine, which is scavenged by…”
Get full text

Mouse models of XRCC1 DNA repair polymorphisms and cancer by LADIGES, W. C

“…DNA damage plays a major role in mutagenesis, carcinogenesis and aging. A gene that is emerging as an essential element in the repair of both damaged bases and…”
Get full text

Adverse Neurological Effects of Short-Term Sleep Deprivation in Aging Mice Are Prevented by SS31 Peptide by Wu, Jinzi, Dou, Yan, Ladiges, Warren C

“…Sleep deprivation is a potent stress factor that disrupts regulatory pathways in the brain resulting in cognitive dysfunction and increased risk of…”
Get full text

Reduction of Age-Associated Pathology in Old Mice by Overexpression of Catalase in Mitochondria by Treuting, Piper M., Linford, Nancy J., Knoblaugh, Sue E., Emond, M. J., Morton, John F., Martin, George M., Rabinovitch, Peter S., Ladiges, Warren C.

“…We describe the effects of mitochondrially targeted catalase (MCAT) expression on end-of-life pathology in mice using detailed semiquantitative…”
Get full text

Author Correction: Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice by McElroy, Gregory S., Chakrabarty, Ram P., D’Alessandro, Karis B., Hu, Yuan-Shih, Vasan, Karthik, Tan, Jerica, Stoolman, Joshua S., Weinberg, Samuel E., Steinert, Elizabeth M., Reyfman, Paul A., Singer, Benjamin D., Ladiges, Warren C., Gao, Lin, Lopéz‑Barneo, José, Ridge, Karen, Budinger, G. R. Scott, Chandel, Navdeep S.

Get full text

Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells by Wiley, Jesse C, Meabon, James S, Frankowski, Harald, Smith, Elise A, Schecterson, Leslayann C, Bothwell, Mark, Ladiges, Warren C

“…The familial and sporadic forms of Alzheimer's disease (AD) have an identical pathology with a severe disparity in the time of onset [1]. The pathological…”
Get full text

Deficiency of the RIIβ subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations by Zheng, Ruimao, Yang, Linghai, Sikorski, Maria A, Enns, Linda C, Czyzyk, Traci A, Ladiges, Warren C, McKnight, G Stanley

“…Targeted disruption of RIIβ-protein kinase A (PKA) in mice leads to a lean phenotype, increased nocturnal locomotor activity, and activation of brown adipose…”
Get full text

Disruption of protein kinase A in mice enhances healthy aging by Enns, Linda C, Morton, John F, Treuting, Piper R, Emond, Mary J, Wolf, Norman S, Dai, Dao-Fu, McKnight, G S, Rabinovitch, Peter S, Ladiges, Warren C

“…Mutations that cause a reduction in protein kinase A (PKA) activity have been shown to extend lifespan in yeast. Loss of function of mammalian RIIbeta, a…”
Get full text

Mutation at the Polymerase Active Site of Mouse DNA Polymerase δ Increases Genomic Instability and Accelerates Tumorigenesis by Venkatesan, Ranga N., Treuting, Piper M., Fuller, Evan D., Goldsby, Robert E., Norwood, Thomas H., Gooley, Ted A., Ladiges, Warren C., Preston, Bradley D., Loeb, Lawrence A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency by Ito, Takashi K, Lu, Chenhao, Khan, Jacob, Nguyen, Quy, Huang, Heather Z, Kim, Dayae, Phillips, James, Tan, Jo, Lee, Yenna, Nguyen, Tuyet, Khessib, Samy, Lim, Natalie, Mekvanich, Surapat, Oh, Joshua, Pineda, Victor V, Wang, Weirong, Bitto, Alessandro, An, Jonathan Y, Morton, John F, Setou, Mitsutoshi, Ladiges, Warren C, Kaeberlein, Matt

“…The inactivation of ribosomal protein S6 kinase 1 (S6K1) recapitulates aspects of caloric restriction and mTORC1 inhibition to achieve prolonged longevity in…”
Get full text

Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice by Frock, Richard L, Chen, Steven C, Da, Dao-Fu, Frett, Ellie, Lau, Carmen, Brown, Christina, Pak, Diana N, Wang, Yuexia, Muchir, Antoine, Worman, Howard J, Santana, Luis F, Ladiges, Warren C, Rabinovitch, Peter S, Kennedy, Brian K

“…Lmna(-/-) mice display multiple tissue defects and die by 6-8 weeks of age reportedly from dilated cardiomyopathy with associated conduction defects. We sought…”
Get full text

Polymorphic variation in hOGG1 and risk of cancer: A review of the functional and epidemiologic literature by Weiss, J.M., Goode, E.L., Ladiges, W.C., Ulrich, Cornelia M.

“…The gene encoding human 8‐oxoguanine glycosylase 1 (hOGG1) is involved in DNA base excision repair. The encoded DNA glycosylase excises…”
Get full text