Search Results - "Ladenheim, B"

Genome-wide DNA hydroxymethylation identifies potassium channels in the nucleus accumbens as discriminators of methamphetamine addiction and abstinence by Cadet, J L, Brannock, C, Krasnova, I N, Jayanthi, S, Ladenheim, B, McCoy, M T, Walther, D, Godino, A, Pirooznia, M, Lee, R S

“…Epigenetic consequences of exposure to psychostimulants are substantial but the relationship of these changes to compulsive drug taking and abstinence is not…”
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Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders by Ayhan, Y, Abazyan, B, Nomura, J, Kim, R, Ladenheim, B, Krasnova, I N, Sawa, A, Margolis, R L, Cadet, J L, Mori, S, Vogel, M W, Ross, C A, Pletnikov, M V

“…Strong genetic evidence implicates mutations and polymorphisms in the gene Disrupted-In-Schizophrenia-1 ( DISC1 ) as risk factors for both schizophrenia and…”
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Chronic co-administration of nicotine and methamphetamine causes differential expression of immediate early genes in the dorsal striatum and nucleus accumbens of Rats by Saint-Preux, F, Bores, L.R, Tulloch, I, Ladenheim, B, Kim, R, Thanos, P.K, Volkow, N.D, Cadet, J.L

“…Highlights • Chronic nicotine and METH, alone, increased striatal expression of nr4a2/nurr1. • Chronic nicotine decreased the expression of all members of the…”
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Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain by COLANTUONI, C, SCHWENKER, J, MCCARTHY, J, RADA, P, LADENHEIM, B, CADET, J.-L, SCHWARTZ, G. J, MORAN, T. H, HOEBEL, B. G

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A single high dose of methamphetamine increases cocaine self-administration by depletion of striatal dopamine in rats by Xi, Z.-X, Kleitz, H.K, Deng, X, Ladenheim, B, Peng, X.-Q, Li, X, Gardner, E.L, Stein, E.A, Cadet, J.L

“…Abstract Psychostimulant addicts often take high doses of drugs, and high doses of psychostimulants such as methamphetamine (METH) are neurotoxic to striatal…”
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Long-Term Protective Effects of Methamphetamine Preconditioning Against Single-Day Methamphetamine Toxic Challenges by Hodges, A B, Ladenheim, B, McCoy, M T, Beauvais, G, Cai, N, Krasnova, I N, Cadet, J L

“…Methamphetamine (METH) use is associated with neurotoxic effects which include decreased levels of dopamine (DA), serotonin (5-HT) and their metabolites in the…”
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Overexpression of human copper/zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (Ecstasy) by Jayanthi, S, Ladenheim, B, Andrews, A.M, Cadet, J.L

“…Administration of 3,4-methylenedioxymethamphetamine (4×20 mg/kg) to non-transgenic CD-1 mice caused marked depletion in dopamine, 3,4-dihydroxyphenylacetic…”
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Amphetamine-induced toxicity in dopamine terminals in CD-1 and C57BL/6J mice: complex roles for oxygen-based species and temperature regulation by Krasnova, I.N, Ladenheim, B, Jayanthi, S, Oyler, J, Moran, T.H, Huestis, M.A, Cadet, J.L

“…In order to examine differential strain susceptibility to neurotoxic effects of amphetamine and to assess the potential role of superoxide radicals in…”
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Molecular Adaptations in the Rat Dorsal Striatum and Hippocampus Following Abstinence-Induced Incubation of Drug Seeking After Escalated Oxycodone Self-Administration by Blackwood, Christopher A., Hoerle, Reece, Leary, Michael, Schroeder, Jennifer, Job, Martin O., McCoy, Michael T., Ladenheim, Bruce, Jayanthi, Subramaniam, Cadet, Jean Lud

“…Repeated exposure to the opioid agonist, oxycodone, can lead to addiction. Here, we sought to identify potential neurobiological consequences of withdrawal…”
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Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2'-NH2-MPTP on serotonergic and noradrenergic nerve terminals by Andrews, A M, Ladenheim, B, Epstein, C J, Cadet, J L, Murphy, D L

“…Administration of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) analog 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP; 4 x 15…”
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Prenatal Interaction of Mutant DISC1 and Immune Activation Produces Adult Psychopathology by Abazyan, Bagrat, Nomura, Jun, Kannan, Geetha, Ishizuka, Koko, Tamashiro, Kellie L, Nucifora, Frederick, Pogorelov, Vladimir, Ladenheim, Bruce, Yang, Chunxia, Krasnova, Irina N, Cadet, Jean Lud, Pardo, Carlos, Mori, Susumu, Kamiya, Atsushi, Vogel, Michael W, Sawa, Akira, Ross, Christopher A, Pletnikov, Mikhail V

“…Background Gene-environment interactions (GEI) are involved in the pathogenesis of mental diseases. We evaluated interaction between mutant human…”
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Methamphetamine induces neuronal apoptosis via cross‐talks between endoplasmic reticulum and mitochondria‐dependent death cascades by Jayanthi, Subramaniam, Deng, Xiaolin, H. Noailles, Pierre‐Antoine, Ladenheim, Bruce, Lud Cadet, Jean

“…Methamphetamine (METH) is an illicit drug that causes neurodegenerative effects in humans. In rodents, METH induces apoptosis of striatal glutamic acid…”
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Calcineurin/NFAT-Induced Up-Regulation of the Fas Ligand/Fas Death Pathway Is Involved in Methamphetamine-Induced Neuronal Apoptosis by Jayanthi, Subramaniam, Deng, Xiaolin, Ladenheim, Bruce, McCoy, Michael T., Cluster, Andrew, Cai, Ning-Sheng, Cadet, Jean Lud, Hökfelt, Tomas

“…Methamphetamine [METH ("speed")] is an abused psychostimulant that can cause psychotic, cognitive, and psychomotor impairment in humans. These signs and…”
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Involvement of oxidative and L-arginine-NO pathways in the neurotoxicity of drugs of abuse in vitro by Cerruti, C, Sheng, P, Ladenheim, B, Epstein, C J, Cadet, J L

“…1. Inhibitors of nitric oxide (NO) formation or ADP-ribosylation attenuate methamphetamine (METH)- and methylenedioxymetamphetamine (MDMA)-induced…”
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Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain by Colantuoni, C, Schwenker, J, McCarthy, J, Rada, P, Ladenheim, B, Cadet, J.-L, Schwartz, G J, Moran, T H, Hoebel, B G

“…Palatable food stimulates neural systems implicated in drug dependence; thus sugar might have effects like a drug of abuse. Rats were given 25% glucose…”
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l -Dopa induced dyskinesias in Parkinsonian mice: Disease severity or l -Dopa history by Shan, Lufei, Diaz, Oscar, Zhang, Yajun, Ladenheim, Bruce, Cadet, Jean-Lud, Chiang, Yung-Hsiao, Olson, Lars, Hoffer, Barry J, Bäckman, Cristina M

“…Abstract In Parkinson’s disease, the efficacy of l -Dopa treatment changes over time, as dyskinesias emerge with previously beneficial doses. Using MitoPark…”
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Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease by Duan, Wenzhen, Ladenheim, Bruce, Cutler, Roy G., Kruman, Inna I., Cadet, Jean Lud, Mattson, Mark P.

“…Although the cause of Parkinson's disease (PD) is unknown, data suggest roles for environmental factors that may sensitize dopaminergic neurons to age‐related…”
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Methamphetamine Administration Causes Death of Dopaminergic Neurons in the Mouse Olfactory Bulb by Deng, Xiaolin, Ladenheim, Bruce, Jayanthi, Subramaniam, Cadet, Jean Lud

“…Background Methamphetamine (METH) is an addictive drug that can cause neurological and psychiatric disorders. In the rodent brain, toxic doses of METH cause…”
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p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism by Duan, Wenzhen, Zhu, Xiaoxiang, Ladenheim, Bruce, Yu, Qian-Sheng, Guo, Zhihong, Oyler, Jon, Cutler, Roy G., Cadet, Jean Lud, Greig, Nigel H., Mattson, Mark P.

“…Drugs currently used for patients with Parkinson's disease provide temporary relief of symptoms but do not halt or slow the underlying neurodegenerative…”
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Neuropeptide Y Protects against Methamphetamine-Induced Neuronal Apoptosis in the Mouse Striatum by Thiriet, Nathalie, Deng, Xiaolin, Solinas, Marcello, Ladenheim, Bruce, Curtis, Wendy, Goldberg, Steven R, Palmiter, Richard D, Cadet, Jean Lud

“…Methamphetamine (METH) is an illicit drug that causes neuronal apoptosis in the mouse striatum, in a manner similar to the neuronal loss observed in…”
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