Search Results - "Ladd, Thomas B"

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2 by Lessard, Christian B, Malnik, Samuel L, Zhou, Yingyue, Ladd, Thomas B, Cruz, Pedro E, Ran, Yong, Mahan, Thomas E, Chakrabaty, Paramita, Holtzman, David M, Ulrich, Jason D, Colonna, Marco, Golde, Todd E

“…Rare coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with increased risk for Alzheimer's disease (AD), but how…”
Get full text

APP-Mediated Signaling Prevents Memory Decline in Alzheimer’s Disease Mouse Model by Deyts, Carole, Clutter, Mary, Pierce, Nicholas, Chakrabarty, Paramita, Ladd, Thomas B., Goddi, Anna, Rosario, Awilda M., Cruz, Pedro, Vetrivel, Kulandaivelu, Wagner, Steven L., Thinakaran, Gopal, Golde, Todd E., Parent, Angèle T.

“…Amyloid precursor protein (APP) and its metabolites play key roles in Alzheimer’s disease (AD) pathophysiology. Whereas short amyloid-β (Aβ) peptides derived…”
Get full text

Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity by Jung, Joo In, Premraj, Sasha, Cruz, Pedro E, Ladd, Thomas B, Kwak, Yewon, Koo, Edward H, Felsenstein, Kevin M, Golde, Todd E, Ran, Yong

“…Altered production of β-amyloid (Aβ) from the amyloid precursor protein (APP) is closely associated with Alzheimer's disease (AD). APP has a number of homo-…”
Get full text

Designing antibodies against LRRK2-targeted tau epitopes by Hamm, Matthew, Ladd, Thomas B, Levites, Yona, Golde, Todd E, Giasson, Benoit I, Lewis, Jada

“…Phosphorylation of the microtubule associated protein tau is an important modulator of its normal physiological functioning; however, it may also contribute to…”
Get full text

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not by Lessard, Christian B, Rodriguez, Edgardo, Ladd, Thomas B, Minter, Lisa M, Osborne, Barbara A, Miele, Lucio, Golde, Todd E, Ran, Yong

“…γ-Secretase is a multiprotein protease that cleaves amyloid protein precursor (APP) and other type I transmembrane proteins. It has two catalytic subunits,…”
Get full text

Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase by Nyborg, Andrew C, Ladd, Thomas B, Jansen, Karen, Kukar, Thomas, Golde, Todd E

“…Signal peptide peptidase (SPP) is an intramembrane cleaving protease (I-CLiP) identified by its cleavage of several type II membrane signal peptides. To date,…”
Get full text

Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates by Nyborg, Andrew C, Ladd, Thomas B, Zwizinski, Craig W, Lah, James J, Golde, Todd E

“…The mammalian Vps10p sorting receptor family is a group of 5 type I membrane homologs (Sortilin, SorLA, and SorCS1-3). These receptors bind various cargo…”
Get full text

A Signal Peptide Peptidase (SPP) Reporter Activity Assay Based on the Cleavage of Type II Membrane Protein Substrates Provides Further Evidence for an Inverted Orientation of the SPP Active Site Relative to Presenilin by Nyborg, Andrew C, Jansen, Karen, Ladd, Thomas B, Fauq, Abdul, Golde, Todd E

“…Signal peptide peptidase (SPP) is an intramembrane-cleaving protease identified by its cleavage of several type II membrane signal peptides after signal…”
Get full text

Short Aβ peptides attenuate Aβ42 toxicity in vivo by Moore, Brenda D, Martin, Jason, de Mena, Lorena, Sanchez, Jonatan, Cruz, Pedro E, Ceballos-Diaz, Carolina, Ladd, Thomas B, Ran, Yong, Levites, Yona, Kukar, Thomas L, Kurian, Justin J, McKenna, Robert, Koo, Edward H, Borchelt, David R, Janus, Christopher, Rincon-Limas, Diego, Fernandez-Funez, Pedro, Golde, Todd E

“…Processing of amyloid-β (Aβ) precursor protein (APP) by γ-secretase produces multiple species of Aβ: Aβ40, short Aβ peptides (Aβ37-39), and longer Aβ peptides…”
Get full text

Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells by Lessard, Christian B., Rodriguez, Edgardo, Ladd, Thomas B., Minter, Lisa M., Osborne, Barbara A., Miele, Lucio, Golde, Todd E., Ran, Yong

“…Presenilins 1 and 2 (PS1 and 2) are the catalytic subunits of γ-secretase, a multiprotein protease that cleaves amyloid protein precursor and other type I…”
Get full text

TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease by Chakrabarty, Paramita, Li, Andrew, Ladd, Thomas B, Strickland, Michael R, Koller, Emily J, Burgess, Jeremy D, Funk, Cory C, Cruz, Pedro E, Allen, Mariet, Yaroshenko, Mariya, Wang, Xue, Younkin, Curtis, Reddy, Joseph, Lohrer, Benjamin, Mehrke, Leonie, Moore, Brenda D, Liu, Xuefei, Ceballos-Diaz, Carolina, Rosario, Awilda M, Medway, Christopher, Janus, Christopher, Li, Hong-Dong, Dickson, Dennis W, Giasson, Benoit I, Price, Nathan D, Younkin, Steven G, Ertekin-Taner, Nilüfer, Golde, Todd E

“…There is considerable interest in harnessing innate immunity to treat Alzheimer's disease (AD). Here, we explore whether a decoy receptor strategy using the…”
Get full text

Substrate-targeting γ-secretase modulators by Kukar, Thomas L., Ladd, Thomas B., Bann, Maralyssa A., Fraering, Patrick C., Narlawar, Rajeshwar, Maharvi, Ghulam M., Healy, Brent, Chapman, Robert, Welzel, Alfred T., Price, Robert W., Moore, Brenda, Rangachari, Vijayaraghavan, Cusack, Bernadette, Eriksen, Jason, Jansen-West, Karen, Verbeeck, Christophe, Yager, Debra, Eckman, Christopher, Ye, Wenjuan, Sagi, Sarah, Cottrell, Barbara A., Torpey, Justin, Rosenberry, Terrone L., Fauq, Abdul, Wolfe, Michael S., Schmidt, Boris, Walsh, Dominic M., Koo, Edward H., Golde, Todd E.

“…Alzheimer's disease: γ-secretase modulators target Aβ42 One promising approach to Alzheimer's disease treatment involves the use of drugs to reduce the rate of…”
Get full text

An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes by Futch, Hunter S, McFarland, Karen N, Moore, Brenda D, Kuhn, M Zino, Giasson, Benoit I, Ladd, Thomas B, Scott, Karen A, Shapiro, Melanie R, Nosacka, Rachel L, Goodwin, Marshall S, Ran, Yong, Cruz, Pedro E, Ryu, Daniel H, Croft, Cara L, Levites, Yona, Janus, Christopher, Chakrabarty, Paramita, Judge, Andrew R, Brusko, Todd M, de Kloet, Annette D, Krause, Eric G, Golde, Todd E

“…Hypothalamic-pituitary-adrenal (HPA) axis dysfunction contributes to numerous human diseases and disorders. We developed a high-affinity monoclonal antibody,…”
Get full text

Steroids as γ‐secretase modulators by Jung, Joo In, Ladd, Thomas B., Kukar, Thomas, Price, Ashleigh R., Moore, Brenda D., Koo, Edward H., Golde, Todd E., Felsenstein, Kevin M.

“…Aggregation and accumulation of Aβ42 play an initiating role in Alzheimer's disease (AD); thus, selective lowering of Aβ42 by γ‐secretase modulators (GSMs)…”
Get full text

Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region by Kukar, Thomas L, Ladd, Thomas B, Robertson, Paul, Pintchovski, Sean A, Moore, Brenda, Bann, Maralyssa A, Ren, Zhao, Jansen-West, Karen, Malphrus, Kim, Eggert, Simone, Maruyama, Hiroko, Cottrell, Barbara A, Das, Pritam, Basi, Guriqbal S, Koo, Edward H, Golde, Todd E

“…γ-Secretase is a multiprotein intramembrane cleaving aspartyl protease (I-CLiP) that catalyzes the final cleavage of the amyloid β precursor protein (APP) to…”
Get full text

γ-Secretase Processing and Effects of γ-Secretase Inhibitors and Modulators on Long Aβ Peptides in Cells by Ran, Yong, Cruz, Pedro E., Ladd, Thomas B., Fauq, Abdul H., Jung, Joo In, Matthews, Julian, Felsenstein, Kevin M., Golde, Todd E.

“…Understanding how different species of Aβ are generated by γ-secretase cleavage has broad therapeutic implications, because shifts in γ-secretase processing…”
Get full text

Cyanobacterial Peptides as a Prototype for the Design of Potent β‑Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases by Liu, Yanxia, Zhang, Wei, Li, Li, Salvador, Lilibeth A., Chen, Tiantian, Chen, Wuyan, Felsenstein, Kevin M., Ladd, Thomas B., Price, Ashleigh R., Golde, Todd E., He, Jianhua, Xu, Yechun, Li, Yingxia, Luesch, Hendrik

“…Inspired by marine cyanobacterial natural products, we synthesized modified peptides with a central statine-core unit, characteristic for aspartic protease…”
Get full text

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice by Rutherford, Nicola J, Sacino, Amanda N, Brooks, Mieu, Ceballos-Diaz, Carolina, Ladd, Thomas B, Howard, Jasie K, Golde, Todd E, Giasson, Benoit I

“…Parkinson's disease (PD) is a progressive neurodegenerative disorder that is pathologically characterized by loss of dopaminergic neurons from the substantia…”
Get full text

Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells by Nyborg, Andrew C, Herl, Lauren, Berezovska, Oksana, Thomas, Anne V, Ladd, Thomas B, Jansen, Karen, Hyman, Bradley T, Golde, Todd E

“…Signal peptide peptidase (SPP) is an intramembrane cleaving protease identified by its cleavage of several type II membrane signal peptides. Conservation of…”
Get full text

Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains by Moore, Brenda D, Chakrabarty, Paramita, Levites, Yona, Kukar, Tom L, Baine, Ann-Marie, Moroni, Tina, Ladd, Thomas B, Das, Pritam, Dickson, Dennis W, Golde, Todd E

“…A hallmark of Alzheimer's disease (AD) is the presence of senile plaques composed of aggregated amyloid β (Aβ) peptides. Pathological aging (PA) is a…”
Get full text