Search Results - "Ladd, Nicole A"
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Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells
Published in Scientific reports (29-12-2022)“…MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early…”
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Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation
Published in Communications biology (24-02-2024)“…MR1-restricted T cells have been implicated in microbial infections, sterile inflammation, wound healing and cancer. Similar to other antigen presentation…”
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Multiple Isomers of Photolumazine V Bind MR1 and Differentially Activate MAIT Cells
Published in The Journal of immunology (1950) (15-03-2024)“…In response to microbial infection, the nonclassical Ag-presenting molecule MHC class I-related protein 1 (MR1) presents secondary microbial metabolites to…”
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Production of MR1 Tetramers Loaded with Microbial Ligands
Published in Methods in molecular biology (Clifton, N.J.) (2020)“…In lieu of peptides, the monomorphic MHC-I-like molecule MR1 presents small molecule antigens to stimulate a subset of αβ T cells known as mucosal-associated…”
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Identifying the Expression Patterns of xCT in Zebrafish to Determine its Role in Neuroregeneration
Published in The FASEB journal (01-04-2017)“…Abstract only System x c − is a heterodimeric amino acid transporter comprised of a transmembrane light chain unit, xCT, and an extracellular heavy chain unit,…”
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