Search Results - "Ladd, Andrea N"

The importance of CELF control: molecular and biological roles of the CUG-BP, Elav-like family of RNA-binding proteins by Dasgupta, Twishasri, Ladd, Andrea N.

“…RNA processing is important for generating protein diversity and modulating levels of protein expression. The CUG‐BP, Elav‐like family (CELF) of RNA‐binding…”
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Identification of Targets of CUG-BP, Elav-Like Family Member 1 (CELF1) Regulation in Embryonic Heart Muscle by Blech-Hermoni, Yotam, Dasgupta, Twishasri, Coram, Ryan J, Ladd, Andrea N

“…CUG-BP, Elav-like family member 1 (CELF1) is a highly conserved RNA binding protein that regulates pre-mRNA alternative splicing, polyadenylation, mRNA…”
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Conserved developmental alternative splicing of muscleblind-like (MBNL) transcripts regulates MBNL localization and activity by Terenzi, Fulvia, Ladd, Andrea N.

“…Muscleblind-like (MBNL) proteins have been shown to regulate pre-mRNA alternative splicing, and MBNL1 has been implicated in regulating fetal-to-adult…”
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Gene Expression Analyses during Spontaneous Reversal of Cardiomyopathy in Mice with Repressed Nuclear CUG-BP, Elav-Like Family (CELF) Activity in Heart Muscle by Dasgupta, Twishasri, Coram, Ryan J, Stillwagon, Samantha J, Ladd, Andrea N

“…CUG-BP, Elav-like family (CELF) proteins regulate cell type- and developmental stage-specific alternative splicing in the heart. Repression of CELF-mediated…”
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Gene expression analyses implicate an alternative splicing program in regulating contractile gene expression and serum response factor activity in mice by Dasgupta, Twishasri, Stillwagon, Samantha J, Ladd, Andrea N

“…Members of the CUG-BP, Elav-like family (CELF) regulate alternative splicing in the heart. In MHC-CELFΔ transgenic mice, CELF splicing activity is inhibited…”
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Expression of a dominant negative CELF protein in vivo leads to altered muscle organization, fiber size, and subtype by Berger, Dara S, Moyer, Michelle, Kliment, Gregory M, van Lunteren, Erik, Ladd, Andrea N

“…CUG-BP and ETR-3-like factor (CELF) proteins regulate tissue- and developmental stage-specific alternative splicing in striated muscle. We previously…”
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neurofibromatosis type I pre-mRNA is a novel target of CELF protein-mediated splicing regulation by Barron, Victoria A, Zhu, Hui, Hinman, Melissa N, Ladd, Andrea N, Lou, Hua

“…The CUG-BP and ETR-3 like factors (CELF) are a family of six highly conserved RNA-binding proteins that preferentially bind to UG-rich sequences. One of the…”
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Identification of transcripts regulated by CUG-BP, Elav-like family member 1 (CELF1) in primary embryonic cardiomyocytes by RNA-seq by Blech-Hermoni, Yotam, Ladd, Andrea N.

“…CUG-BP, Elav-like family member 1 (CELF1) is a multi-functional RNA binding protein that regulates pre-mRNA alternative splicing in the nucleus, as well as…”
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Dynamic balance between activation and repression regulates pre‐mRNA alternative splicing during heart development by Ladd, Andrea N., Stenberg, Myrna G., Swanson, Maurice S., Cooper, Thomas A.

“…Cardiac troponin T (cTNT) exon 5 splicing is developmentally regulated such that it is included in embryonic but not adult heart. CUG‐BP and ETR‐3‐like factor…”
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Cloning and embryonic expression patterns of the chicken CELF family by Brimacombe, Kyle R., Ladd, Andrea N.

“…The CUG‐BP and ETR‐3‐like factor (CELF) protein family has been implicated in the regulation of pre‐mRNA alternative splicing, mRNA stability, and translation…”
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Cardiac Tissue-Specific Repression of CELF Activity Disrupts Alternative Splicing and Causes Cardiomyopathy by Ladd, Andrea N., Taffet, George, Hartley, Craig, Kearney, Debra L., Cooper, Thomas A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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CELF6, a Member of the CELF Family of RNA-binding Proteins, Regulates Muscle-specific Splicing Enhancer-dependent Alternative Splicing by Ladd, Andrea N., Nguyen, Nicole H., Malhotra, Kavin, Cooper, Thomas A.

“…We previously described a family of five RNA-binding proteins: CUG-binding protein, embryonic lethal abnormal vision-type RNA-binding protein 3, and the…”
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RNA binding proteins in the regulation of heart development by Blech-Hermoni, Yotam, Ladd, Andrea N.

“…In vivo, RNA molecules are constantly accompanied by RNA binding proteins (RBPs), which are intimately involved in every step of RNA biology, including…”
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Multiple domains control the subcellular localization and activity of ETR-3, a regulator of nuclear and cytoplasmic RNA processing events by Ladd, Andrea N, Cooper, Thomas A

“…Embryonic lethal abnormal vision (ELAV) type RNA binding protein 3 (ETR-3; also called NAPOR, CUGBP2, or BRUNOL3) has been implicated in the regulation of…”
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CUG-BP, Elav-like family (CELF)-mediated alternative splicing regulation in the brain during health and disease by Ladd, Andrea N.

“…Alternative splicing is an important mechanism for generating transcript and protein diversity. In the brain, alternative splicing is particularly prevalent,…”
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CUG‐BP, Elav‐like family member 1 (CELF1) is required for normal myofibrillogenesis, morphogenesis, and contractile function in the embryonic heart by Blech‐Hermoni, Yotam, Sullivan, Connor B., Jenkins, Michael W., Wessely, Oliver, Ladd, Andrea N.

“…Background: CUG‐BP, Elav‐like family member 1 (CELF1) is a multifunctional RNA binding protein found in a variety of adult and embryonic tissues. In the heart,…”
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The CELF Family of RNA Binding Proteins Is Implicated in Cell-Specific and Developmentally Regulated Alternative Splicing by Ladd, A N, Charlet, N, Cooper, T A

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Alternative splicing of the neurofibromatosis type 1 pre-mRNA is regulated by the muscleblind-like proteins and the CUG-BP and ELAV-like factors by Fleming, Victoria A, Geng, Cuiyu, Ladd, Andrea N, Lou, Hua

“…Alternative splicing is often subjected to complex regulatory control that involves many protein factors and cis-acting RNA sequence elements. One major…”
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Muscleblind-like 1 is required for normal heart valve development in vivo by Coram, Ryan J, Stillwagon, Samantha J, Guggilam, Anuradha, Jenkins, Michael W, Swanson, Maurice S, Ladd, Andrea N

“…Development of the valves and septa of the heart depends on the formation and remodeling of the endocardial cushions in the atrioventricular canal and outflow…”
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Differential susceptibility of muscles to myotonia and force impairment in a mouse model of myotonic dystrophy by Moyer, Michelle, Berger, Dara S., Ladd, Andrea N., Van Lunteren, Erik

“…Introduction: Myotonic dystrophy, or dystrophia myotonica (DM), is characterized by prominent muscle wasting and weakness as well as delayed muscle relaxation…”
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