Experimental infection of cattle with the agents of transmissible mink encephalopathy and scrapie

Cattle are susceptible to experimental infection with the Stetsonville isolate of the transmissible mink encephalopathy (TME) agent. To determine if they are susceptible to other TME isolates, two groups of calves were inoculated intracerebrally with homogenate of mink brain containing the Hayward i...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of comparative pathology Vol. 113; no. 3; pp. 241 - 251
Main Authors:	Robinson, M.M., Hadlow, W.J., Knowles, D.P., Huff, T.P., Lacy, P.A., Marsh, R.F., Gorham, J.R.
Format:	Journal Article
Language:	English
Published:	London Elsevier Ltd 01-10-1995 Elsevier
Subjects:	Animals Biological and medical sciences Brain - pathology Brain Diseases - pathology Brain Diseases - veterinary Cattle Cattle Diseases - pathology Disease Susceptibility Experimental viral diseases and models Female Genotype Goats Infectious diseases Male Medical sciences Mink Nerve Tissue Proteins - genetics Nervous System - pathology Prions - genetics Prions - pathogenicity Scrapie - pathology Sheep Viral diseases Bovine Pathogenesis Transmissible mink encephalopathy virus Scrapie agent Cerebral disorder Virus Vertebrata Experimental disease Mammalia Animal Central nervous system disease Artiodactyla Ungulata
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Cattle are susceptible to experimental infection with the Stetsonville isolate of the transmissible mink encephalopathy (TME) agent. To determine if they are susceptible to other TME isolates, two groups of calves were inoculated intracerebrally with homogenate of mink brain containing the Hayward isolate or the Blackfoot isolate. For comparison, a third group was inoculated with a brain homogenate from a steer infected with the Stetsonville isolate in its primary cattle passage and a fourth group was inoculated with a pool of brain homogenate from three cattle experimentally infected with a sheep and goat scrapie agent in its primary cattle passage. Clinical signs of neurological disease appeared in each steer of every group between 15 and 25 months after inoculation. An encephalopathy characterized by severe spongiform change and pronounced astrocytosis occurred in the three groups inoculated with the TME agent. In contrast, the neurohistological changes in the steers inoculated with the cattle-passaged scrapie agent were slight and subtle. Analysis of the octapeptide repeat region of the bovine protease-resistant protein (PrP) gene showed that variations in incubation period, clinical signs, and neurohistological changes were unrelated to the homozygous or heterozygous condition of six or six/five octapeptide repeats.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0021-9975 1532-3129
DOI:	10.1016/S0021-9975(05)80039-8