Search Results - "Lacroix, Ian S."

Effect of leukoreduction on the omics phenotypes of canine packed red blood cells during refrigerated storage by Miglio, Arianna, Rocconi, Francesca, Cremoni, Valentina, D'Alessandro, Angelo, Reisz, Julie A., Maslanka, Mark, Lacroix, Ian S., Di Francesco, Daniela, Antognoni, Maria T., Di Tommaso, Morena

“…Background Red blood cell (RBC) storage promotes biochemical and morphological alterations, collectively referred to as storage lesions (SLs). Studies in…”
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Effect of leukoreduction on the metabolism of equine packed red blood cells during refrigerated storage by Miglio, Arianna, Rocconi, Francesca, Cremonini, Valentina, D'Alessandro, Angelo, Reisz, Julie A., Maslanka, Mark, Lacroix, Ian S., Tiscar, Giorgio, Di Tommaso, Morena, Antognoni, Maria T.

“…Background Understanding of the biochemical and morphological lesions associated with storage of equine blood is limited. Objective To demonstrate the temporal…”
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Omics Markers of Red Blood Cell Transfusion in Trauma by LaCroix, Ian S, Cohen, Mitchell, Moore, Ernest E, Dzieciatkowska, Monika, Nemkov, Travis, Schaid, Jr, Terry R, Debot, Margaret, Jones, Kenneth, Silliman, Christopher C, Hansen, Kirk C, D'Alessandro, Angelo

“…Red blood cell (RBC) transfusion is a life-saving intervention for millions of trauma patients every year worldwide. While hemoglobin thresholds are clinically…”
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Metabolic correlates to critical speed in murine models of sickle cell disease by Cendali, Francesca I, Nemkov, Travis, Lisk, Christina, Lacroix, Ian S, Nouraie, Seyed-Mehdi, Zhang, Yingze, Gordeuk, Victor R, Buehler, Paul W, Irwin, David, D'Alessandro, Angelo

“…Exercise intolerance is a common clinical manifestation in patients with sickle cell disease (SCD), though the mechanisms are incompletely understood. Here we…”
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The iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI by Kim, Sun A., LaCroix, Ian S., Gerber, Scott A., Guerinot, Mary Lou

“…Iron is an essential nutrient for plants, but excess iron is toxic due to its catalytic role in the formation of hydroxyl radicals. Thus, iron uptake is highly…”
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Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes by Wolf, Bennett K., Zhao, Yanding, McCray, Andrew, Hawk, William H., Deary, Luke T., Sugiarto, Nicholas W., LaCroix, Ian S., Gerber, Scott A., Cheng, Chao, Wang, Xiaofeng

“…The mechanism controlling the dynamic targeting of SWI/SNF has long been postulated to be coordinated by transcription factors (TFs), yet demonstrating a…”
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Let-7b-5p in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic sensitivity of P. aeruginosa by Koeppen, Katja, Nymon, Amanda, Barnaby, Roxanna, Bashor, Laura, Li, Zhongyou, Hampton, Thomas H., Liefeld, Amanda E., Kolling, Fred W., LaCroix, Ian S., Gerber, Scott A., Hogan, Deborah A., Kasetty, Swetha, Nadell, Carey D., Stanton, Bruce A.

“…Pseudomonas aeruginosa is an opportunistic pathogen that forms antibiotic-resistant biofilms, which facilitate chronic infections in immunocompromised hosts…”
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Multiomics Signatures of Coagulopathy in a Polytrauma Swine Model Contrasted with Severe Multisystem Injured Patients by LaCroix, Ian S., Moore, Ernest E., Cralley, Alexis, Cendali, Francesca I., Dzieciatkowska, Monika, Hom, Patrick, Mitra, Sanchayita, Cohen, Mitchell, Silliman, Christopher, Hansen, Kirk C., D’Alessandro, Angelo

“…Trauma-induced coagulopathy (TIC) is a leading contributor to preventable mortality in severely injured patients. Understanding the molecular drivers of TIC is…”
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Omics markers of platelet transfusion in trauma patients by LaCroix, Ian S., Cohen, Mitchell, Moore, Ernest E., Dzieciatkowska, Monika, Silliman, Christopher C., Hansen, Kirk C., D'Alessandro, Angelo

“…Background Even in the era of the COVID‐19 pandemic, trauma remains the global leading cause of mortality under the age of 49. Trauma‐induced coagulopathy is a…”
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Trauma patients with type O blood exhibit unique multiomics signature with decreased lectin pathway of complement levels by Stocker, Benjamin W, LaCroix, Ian S, Erickson, Christopher, Gallagher, Lauren T, Ramser, Benjamin J, Thielen, Otto, Hallas, William, Mitra, Sanchayita, Moore, Ernest E, Hansen, Kirk, D'Alessandro, Angelo, Silliman, Christopher C, Cohen, Mitchell J

“…Patients with type O blood may have an increased risk of hemorrhagic complications because of lower baseline levels of von Willebrand factor and factor VIII,…”
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Regulation of kynurenine metabolism by blood donor genetics and biology impacts red cell hemolysis in vitro and in vivo by Nemkov, Travis, Stephenson, Daniel, Erickson, Christopher, Dzieciatkowska, Monika, Key, Alicia, Moore, Amy, Earley, Eric J, Page, Grier P, Lacroix, Ian S, Stone, Mars, Deng, Xutao, Raife, Thomas, Kleinman, Steven, Zimring, James C, Roubinian, Nareg, Hansen, Kirk C, Busch, Michael P, Norris, Philip J, D'Alessandro, Angelo

“…In the field of transfusion medicine, the clinical relevance of the metabolic markers of the red blood cell (RBC) storage lesion is incompletely understood…”
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Omics Signatures of Tissue Injury and Hemorrhagic Shock in Swine by LaCroix, Ian S., Cralley, Alexis, Moore, Ernest E., Cendali, Francesca I., Dzieciatkowska, Monika, Hom, Patrick, Mitra, Sanchayita, Cohen, Mitchell, Silliman, Christopher, Sauaia, Angela, Hansen, Kirk C., D’Alessandro, Angelo

“…Advanced mass spectrometry methods were leveraged to analyze both proteomics and metabolomics signatures in plasma upon controlled tissue injury (TI) and…”
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Pharmacological induction of chromatin remodeling drives chemosensitization in triple-negative breast cancer by Bagheri, Meisam, Mohamed, Gadisti Aisha, Mohamed Saleem, Mohammed Ashick, Ognjenovic, Nevena B., Lu, Hanxu, Kolling, Fred W., Wilkins, Owen M., Das, Subhadeep, LaCroix, Ian S., Nagaraj, Shivashankar H., Muller, Kristen E., Gerber, Scott A., Miller, Todd W., Pattabiraman, Diwakar R.

“…Targeted therapies have improved outcomes for certain cancer subtypes, but cytotoxic chemotherapy remains a mainstay for triple-negative breast cancer (TNBC)…”
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Increased exercise tolerance in humanized G6PD deficient mice by Cendali, Francesca I, Lisk, Christina, Dzieciatkowska, Monika, LaCroix, Ian S, Reisz, Julie A., Harral, Julie, Stephenson, Daniel, Hay, Ariel M, Wartchow, Eric, Darehshouri, Anza, Dziewulska, Karolina, Buehler, Paul W, Norris, Philip J, Deng, Xutao, Busch, Michael P., Earley, Eric J, Page, Grier P, Hansen, Kirk C, Zimring, James C, Irwin, David, Nemkov, Travis, D'Alessandro, Angelo

“…Glucose-6-phosphate dehydrogenase (G6PD) deficiency affects 500 million people globally, impacting red blood cell (RBC) antioxidant pathways and increasing…”
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Abstract P3-06-01: Eribulin alters the chromatin landscape to induce MET, attenuating metastatic progression and sensitizing breast tumors to subsequent chemotherapy by Pattabiraman, Diwakar R, Bagheri, Meisam, Ognjenovic, Nevena B, LaCroix, Ian S, Gerber, Scott A

“…Abstract Introduction: Two major hurdles faced in clinical cancer therapy are metastatic progression that results in the majority of cancer deaths, and…”
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Abstract 1417: Curtailing epithelial-mesenchymal plasticity for improved response to breast cancer therapy by Bagheri, Meisam, LaCroix, Ian S., Wang, Xiaofeng, Gerber, Scott A., Pattabiraman, Diwakar R.

“…Abstract Introduction: Two major hurdles faced in clinical cancer therapy are metastatic progression that results in the majority of cancer deaths, and…”
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Abstract 1785: Eribulin alters the chromatin landscape to induce MET, attenuating metastatic progression sensitizing breast tumors to subsequent chemotherapy by Bagheri, Meisam, Ognjenovic, Nevena B., Mohamed, Gadisti Aisha, LaCroix, Ian S., McCray, Andrew, Muller, Kristen E., Wang, Xiaofeng, Gerber, Scott A., Pattabiraman, Diwakar R.

“…Abstract Introduction: Two major hurdles faced in clinical cancer therapy are metastatic progression that results in the majority of cancer deaths, and…”
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