Search Results - "Lacro, Ronald"

Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association by Pierpont, Mary Ella, Brueckner, Martina, Chung, Wendy K., Garg, Vidu, Lacro, Ronald V., McGuire, Amy L., Mital, Seema, Priest, James R., Pu, William T., Roberts, Amy, Ware, Stephanie M., Gelb, Bruce D., Russell, Mark W.

“…This review provides an updated summary of the state of our knowledge of the genetic contributions to the pathogenesis of congenital heart disease. Since 2007,…”
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Angiotensin receptor blockers and β blockers in Marfan syndrome: an individual patient data meta-analysis of randomised trials by Pitcher, Alex, Spata, Enti, Emberson, Jonathan, Davies, Kelly, Halls, Heather, Holland, Lisa, Wilson, Kate, Reith, Christina, Child, Anne H, Clayton, Tim, Dodd, Matthew, Flather, Marcus, Jin, Xu Yu, Sandor, George, Groenink, Maarten, Mulder, Barbara, De Backer, Julie, Evangelista, Arturo, Forteza, Alberto, Teixido-Turà, Gisela, Boileau, Catherine, Jondeau, Guillaume, Milleron, Olivier, Lacro, Ronald V, Sleeper, Lynn A, Chiu, Hsin-Hui, Wu, Mei-Hwan, Neubauer, Stefan, Watkins, Hugh, Dietz, Hal, Baigent, Colin

“…Angiotensin receptor blockers (ARBs) and β blockers are widely used in the treatment of Marfan syndrome to try to reduce the rate of progressive aortic root…”
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Increased Vertebral Artery Tortuosity Index Is Associated With Adverse Outcomes in Children and Young Adults With Connective Tissue Disorders by MORRIS, Shaine A, ORBACH, Darren B, GEVA, Tal, SINGH, Michael N, GAUVREAU, Kimberlee, LACRO, Ronald V

“…Arterial tortuosity is described as a common and distinctive feature of Loeys-Dietz syndrome (LDS), yet reports on arterial tortuosity are based on qualitative…”
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Health Supervision for Children and Adolescents With Marfan Syndrome by Tinkle, Brad T, Lacro, Ronald V, Burke, Leah W

“…Marfan syndrome is a heritable connective tissue disorder that affects many different organ systems. In some cases, features of Marfan syndrome can be…”
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Bicuspid aortic valve and its ascending aortopathy by Dunne, Emma C., Lacro, Ronald V., Flyer, Jonathan N.

“…To synthesize and critically assess recent clinical and research advancements in pediatric bicuspid aortic valve (BAV) and its associated aortopathy. In…”
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Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome by Lacro, Ronald V, Dietz, Harry C, Sleeper, Lynn A, Yetman, Anji T, Bradley, Timothy J, Colan, Steven D, Pearson, Gail D, Selamet Tierney, E. Seda, Levine, Jami C, Atz, Andrew M, Benson, D. Woodrow, Braverman, Alan C, Chen, Shan, De Backer, Julie, Gelb, Bruce D, Grossfeld, Paul D, Klein, Gloria L, Lai, Wyman W, Liou, Aimee, Loeys, Bart L, Markham, Larry W, Olson, Aaron K, Paridon, Stephen M, Pemberton, Victoria L, Pierpont, Mary Ella, Pyeritz, Reed E, Radojewski, Elizabeth, Roman, Mary J, Sharkey, Angela M, Stylianou, Mario P, Wechsler, Stephanie Burns, Young, Luciana T, Mahony, Lynn

“…In this study, children and young adults with Marfan's syndrome were randomly assigned to receive atenolol or losartan and were followed for 3 years. There was…”
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Molecular characterization and investigation of the role of genetic variation in phenotypic variability and response to treatment in a large pediatric Marfan syndrome cohort by Meester, Josephina A.N., Peeters, Silke, Van Den Heuvel, Lotte, Vandeweyer, Geert, Fransen, Erik, Cappella, Elizabeth, Dietz, Harry C., Forbus, Geoffrey, Gelb, Bruce D., Goldmuntz, Elizabeth, Hoskoppal, Arvind, Landstrom, Andrew P., Lee, Teresa, Mital, Seema, Morris, Shaine, Olson, Aaron K., Renard, Marjolijn, Roden, Dan M., Singh, Michael N., Selamet Tierney, Elif Seda, Tretter, Justin T., Van Driest, Sara L., Willing, Marcia, Verstraeten, Aline, Van Laer, Lut, Lacro, Ronald V., Loeys, Bart L.

“…In a large cohort of 373 pediatric patients with Marfan syndrome (MFS) with a severe cardiovascular phenotype, we explored the proportion of patients with MFS…”
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Performant Mutation Identification Using Targeted Next-Generation Sequencing of 14 Thoracic Aortic Aneurysm Genes by Proost, Dorien, Vandeweyer, Geert, Meester, Josephina A.N., Salemink, Simone, Kempers, Marlies, Ingram, Christie, Peeters, Nils, Saenen, Johan, Vrints, Christiaan, Lacro, Ronald V., Roden, Dan, Wuyts, Wim, Dietz, Harry C., Mortier, Geert, Loeys, Bart L., Van Laer, Lut

“…ABSTRACT At least 14 causative genes have been identified for both syndromic and nonsyndromic forms of thoracic aortic aneurysm/dissection (TAA), an important…”
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Pulmonary Artery Hypertension in Formerly Premature Infants With Bronchopulmonary Dysplasia: Clinical Features and Outcomes in the Surfactant Era by Khemani, Ekta, McElhinney, Doff B, Rhein, Lawrence, Andrade, Olyn, Lacro, Ronald V, Thomas, Kristin C, Mullen, Mary P

“…Although abnormal pulmonary vascular structure and function in preterm infants with bronchopulmonary dysplasia may predispose infants to pulmonary artery…”
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Recent Clinical Drug Trials Evidence in Marfan Syndrome and Clinical Implications by Singh, Michael N., MD, Lacro, Ronald V., MD

“…Abstract Marfan syndrome is a genetic disorder of connective tissue with principal manifestations in the cardiovascular, ocular, and skeletal systems…”
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Cardiovascular Management of Aortopathy in Children: A Scientific Statement From the American Heart Association by Morris, Shaine A, Flyer, Jonathan N, Yetman, Anji T, Quezada, Emilio, Cappella, Elizabeth S, Dietz, Harry C, Milewicz, Dianna M, Ouzounian, Maral, Rigelsky, Christina M, Tierney, Seda, Lacro, Ronald V

“…Aortopathy encompasses a spectrum of conditions predisposing to dilation, aneurysm, dissection, or rupture of the aorta and other blood vessels. Aortopathy is…”
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Longitudinal Changes in Segmental Aortic Stiffness Determined by Cardiac Magnetic Resonance in Children and Young Adults With Connective Tissue Disorders (the Marfan, Loeys-Dietz, and Ehlers-Danlos Syndromes, and Nonspecific Connective Tissue Disorders) by Merlocco, Anthony, Lacro, Ronald V., Gauvreau, Kimberlee, Rabideau, Nicole, Singh, Michael N., Prakash, Ashwin

“…Aortic stiffness measured by cardiac magnetic resonance (CMR) in connective tissue disorder (CTD) patients has been previously shown to be abnormal and to be…”
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Echocardiographic image collection and evaluation in infants with CHD: lessons learned from the imaging core lab for the Residual Lesion Score study by Levine, Jami C, Colan, Steven, Trachtenberg, Felicia, Marcus, Edward, Ferguson, Matthew, Parthiban, Anitha, Taylor, Carolyn, Dragulescu, Andreea, Goot, Benjamin, Lacro, Ronald V, McFarland, Carol, Narasimhan, Shanthi, O'Connor, Matthew, Schamberger, Marcus, Srivistava, Shubhika, Taylor, Michael, Nathan, Meena

“…Many factors affect patient outcome after congenital heart surgery, including the complexity of the heart disease, pre-operative status, patient specific…”
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Effect of Losartan or Atenolol on Children and Young Adults With Bicuspid Aortic Valve and Dilated Aorta by Flyer, Jonathan N., Sleeper, Lynn A., Colan, Steven D., Singh, Michael N., Lacro, Ronald V.

“…•Bicuspid aortopathy increases aortic aneurysm and dissection risk.•Medical prophylaxis reduces aortic growth rates in other types of aortopathy.•Therapy with…”
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Cardiovascular disease in Noonan syndrome by Prendiville, Terence W, Gauvreau, Kimberlee, Tworog-Dube, Erica, Patkin, Lynne, Kucherlapati, Raju S, Roberts, Amy E, Lacro, Ronald V

“…Background Noonan syndrome (NS), a relatively common autosomal dominant disorder with an incidence of 1 in 1000 to 2500 live births, is the most common…”
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Genome Sequencing Identifies the Pathogenic Variant Missed by Prior Testing in an Infant with Marfan Syndrome by Wojcik, Monica H., Thiele, Katri, Grant, Carly F., Chao, Katherine, Goodrich, Julia, O'Donnell-Luria, Anne, Lacro, Ronald V., Tan, Wen-Hann, Agrawal, Pankaj B.

“…We describe an infant with a phenotype typical of early onset Marfan syndrome whose genetic evaluation, including Sanger sequencing and deletion/duplication…”
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Segmental Aortic Stiffness in Children and Young Adults With Connective Tissue Disorders: Relationships With Age, Aortic Size, Rate of Dilation, and Surgical Root Replacement by Prakash, Ashwin, Adlakha, Himanshu, Rabideau, Nicole, Hass, Cara J, Morris, Shaine A, Geva, Tal, Gauvreau, Kimberlee, Singh, Michael N, Lacro, Ronald V

“…BACKGROUND—Aortic diameter is an imperfect predictor of aortic complications in connective tissue disorders (CTDs). Novel indicators of vascular phenotype…”
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Growth, development, and phenotypic spectrum of individuals with deletions of 2q33.1 involving SATB2 by Zarate, Yuri A., Bosanko, Katherine A., Thomas, Mary Ann, Miller, David T., Cusmano‐Ozog, Kristina, Martinez‐Monseny, Antonio, Curry, Cynthia J., Graham, John M., Velsher, Lea, Bekheirnia, Mir Reza, Seidel, Veronica, Dedousis, Demitrios, Mitchell, Anna L., DiMarino, Amy M., Riess, Angelika, Balasubramanian, Meena, Fish, Jennifer L., Caffrey, Aisling R., Fleischer, Nicole, Pierson, Tyler Mark, Lacro, Ronald V.

“…SATB2‐Associated syndrome (SAS) is an autosomal dominant, multisystemic, neurodevelopmental disorder due to alterations in SATB2 at 2q33.1. A limited number of…”
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MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus by Quintero-Rivera, Fabiola, Xi, Qiongchao J, Keppler-Noreuil, Kim M, Lee, Ji Hyun, Higgins, Anne W, Anchan, Raymond M, Roberts, Amy E, Seong, Ihn Sik, Fan, Xueping, Lage, Kasper, Lu, Lily Y, Tao, Joanna, Hu, Xuchen, Berezney, Ronald, Gelb, Bruce D, Kamp, Anna, Moskowitz, Ivan P, Lacro, Ronald V, Lu, Weining, Morton, Cynthia C, Gusella, James F, Maas, Richard L

“…Cardiac left ventricular outflow tract (LVOT) defects represent a common but heterogeneous subset of congenital heart disease for which gene identification has…”
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Extracardiac Manifestations Fail to Predict the Severity of Cardiac Phenotype in Children and Young Adults with Marfan Syndrome by John, Sheba, Young, Luciana T, Lacro, Ronald V, Hoskoppal, Arvind, Ou, Zhining, Presson, Angela P, Johnson, Joyce T, Andrade, Lauren, Minich, L LuAnn, Menon, Shaji

“…We performed a secondary analysis of the Pediatric Heart Network (PHN) Marfan Trial public-use database to evaluate associations between extracardiac features…”
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