Search Results - "Lacoux, Caroline"

Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis by Torrino, Stéphanie, Grasset, Eloise M., Audebert, Stephane, Belhadj, Ilyes, Lacoux, Caroline, Haynes, Meagan, Pisano, Sabrina, Abélanet, Sophie, Brau, Frederic, Chan, Stephen Y., Mari, Bernard, Oldham, William M., Ewald, Andrew J., Bertero, Thomas

“…Mechanical signals from the tumor microenvironment modulate cell mechanics and influence cell metabolism to promote cancer aggressiveness. Cells withstand…”
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Versatile and flexible microfluidic qPCR test for high-throughput SARS-CoV-2 and cellular response detection in nasopharyngeal swab samples by Fassy, Julien, Lacoux, Caroline, Leroy, Sylvie, Noussair, Latifa, Hubac, Sylvain, Degoutte, Aurélien, Vassaux, Georges, Leclercq, Vianney, Rouquié, David, Marquette, Charles-Hugo, Rottman, Martin, Touron, Patrick, Lemoine, Antoinette, Herrmann, Jean-Louis, Barbry, Pascal, Nahon, Jean-Louis, Zaragosi, Laure-Emmanuelle, Mari, Bernard

“…The emergence and quick spread of SARS-CoV-2 has pointed at a low capacity response for testing large populations in many countries, in line of material,…”
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Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma by Diazzi, Serena, Baeri, Alberto, Fassy, Julien, Lecacheur, Margaux, Marin‐Bejar, Oskar, Girard, Christophe A, Lefevre, Lauren, Lacoux, Caroline, Irondelle, Marie, Mounier, Carine, Truchi, Marin, Couralet, Marie, Ohanna, Mickael, Carminati, Alexandrine, Berestjuk, Ilona, Larbret, Frederic, Gilot, David, Vassaux, Georges, Marine, Jean‐Christophe, Deckert, Marcel, Mari, Bernard, Tartare‐Deckert, Sophie

“…Lineage dedifferentiation toward a mesenchymal‐like state displaying myofibroblast and fibrotic features is a common mechanism of adaptive and acquired…”
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Detecting subtle transcriptomic perturbations induced by lncRNAs knock-down in single-cell CRISPRi screening using a new sparse supervised autoencoder neural network by Truchi, Marin, Lacoux, Caroline, Gille, Cyprien, Fassy, Julien, Magnone, Virginie, Lopes Goncalves, Rafael, Girard-Riboulleau, Cédric, Manosalva-Pena, Iris, Gautier-Isola, Marine, Lebrigand, Kevin, Barbry, Pascal, Spicuglia, Salvatore, Vassaux, Georges, Rezzonico, Roger, Barlaud, Michel, Mari, Bernard

“…Single-cell CRISPR-based transcriptome screens are potent genetic tools for concomitantly assessing the expression profiles of cells targeted by a set of…”
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Monitoring SARS-CoV-2 variants alterations in Nice neighborhoods by wastewater nanopore sequencing by Rios, Géraldine, Lacoux, Caroline, Leclercq, Vianney, Diamant, Anna, Lebrigand, Kévin, Lazuka, Adèle, Soyeux, Emmanuel, Lacroix, Sébastien, Fassy, Julien, Couesnon, Aurélie, Thiery, Richard, Mari, Bernard, Pradier, Christian, Waldmann, Rainer, Barbry, Pascal

“…Wastewater surveillance was proposed as an epidemiological tool to define the prevalence and evolution of the SARS-CoV-2 epidemics. However, most implemented…”
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The catalytic activity of the translation termination factor methyltransferase Mtq2-Trm112 complex is required for large ribosomal subunit biogenesis by Lacoux, Caroline, Wacheul, Ludivine, Saraf, Kritika, Pythoud, Nicolas, Huvelle, Emmeline, Figaro, Sabine, Graille, Marc, Carapito, Christine, Lafontaine, Denis L J, Heurgué-Hamard, Valérie

“…Abstract The Mtq2-Trm112 methyltransferase modifies the eukaryotic translation termination factor eRF1 on the glutamine side chain of a universally conserved…”
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Absence of the Fragile X Mental Retardation Protein results in defects of RNA editing of neuronal mRNAs in mouse by Filippini, Alice, Bonini, Daniela, Lacoux, Caroline, Pacini, Laura, Zingariello, Maria, Sancillo, Laura, Bosisio, Daniela, Salvi, Valentina, Mingardi, Jessica, La Via, Luca, Zalfa, Francesca, Bagni, Claudia, Barbon, Alessandro

“…The fragile X syndrome (FXS), the most common form of inherited intellectual disability, is due to the absence of FMRP, a protein regulating RNA metabolism…”
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Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension by Tai, Yi-Yin, Yu, Qiujun, Tang, Ying, Sun, Wei, Kelly, Neil J, Okawa, Satoshi, Zhao, Jingsi, Schwantes-An, Tae-Hwi, Lacoux, Caroline, Torrino, Stephanie, Al Aaraj, Yassmin, El Khoury, Wadih, Negi, Vinny, Liu, Mingjun, Corey, Catherine G, Belmonte, Frances, Vargas, Sara O, Schwartz, Brian, Bhat, Bal, Chau, B Nelson, Karnes, Jason H, Satoh, Taijyu, Barndt, Robert J, Wu, Haodi, Parikh, Victoria N, Wang, Jianrong, Zhang, Yingze, McNamara, Dennis, Li, Gang, Speyer, Gil, Wang, Bing, Shiva, Sruti, Kaufman, Brett, Kim, Seungchan, Gomez, Delphine, Mari, Bernard, Cho, Michael H, Boueiz, Adel, Pauciulo, Michael W, Southgate, Laura, Trembath, Richard C, Sitbon, Olivier, Humbert, Marc, Graf, Stefan, Morrell, Nicholas W, Rhodes, Christopher J, Wilkins, Martin R, Nouraie, Mehdi, Nichols, William C, Desai, Ankit A, Bertero, Thomas, Chan, Stephen Y

“…Hypoxic reprogramming of vasculature relies on genetic, epigenetic, and metabolic circuitry, but the control points are unknown. In pulmonary arterial…”
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BC1-FMRP interaction is modulated by 2'-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapses by Lacoux, Caroline, Di Marino, Daniele, Boyl, Pietro Pilo, Zalfa, Francesca, Yan, Bing, Ciotti, Maria Teresa, Falconi, Mattia, Urlaub, Henning, Achsel, Tilmann, Mougin, Annie, Caizergues-Ferrer, Michèle, Bagni, Claudia

“…The brain cytoplasmic RNA, BC1, is a small non-coding RNA that is found in different RNP particles, some of which are involved in translational control. One…”
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Dynamic insights on transcription initiation and RNA processing during bacterial adaptation by Lacoux, Caroline, Fouquier d'Hérouël, Aymeric, Wessner-Le Bohec, Françoise, Innocenti, Nicolas, Bohn, Chantal, Kennedy, Sean P, Rochat, Tatiana, Bonnin, Rémy A, Serror, Pascale, Aurell, Erik, Bouloc, Philippe, Repoila, Francis

“…Transcription initiation and RNA processing govern gene expression and enable bacterial adaptation by reshaping the RNA landscape. The aim of this study was to…”
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Whole-genome mapping of 5' RNA ends in bacteria by tagged sequencing: a comprehensive view in Enterococcus faecalis by Innocenti, Nicolas, Golumbeanu, Monica, Fouquier d'Hérouël, Aymeric, Lacoux, Caroline, Bonnin, Rémy A, Kennedy, Sean P, Wessner, Françoise, Serror, Pascale, Bouloc, Philippe, Repoila, Francis, Aurell, Erik

“…Enterococcus faecalis is the third cause of nosocomial infections. To obtain the first snapshot of transcriptional organizations in this bacterium, we used a…”
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An international, interlaboratory ring trial confirms the feasibility of an extraction-less "direct" RT-qPCR method for reliable detection of SARS-CoV-2 RNA in clinical samples by Mills, Margaret G, Bruce, Emily, Huang, Meei-Li, Crothers, Jessica W, Hyrien, Ollivier, Oura, Christopher A L, Blake, Lemar, Brown Jordan, Arianne, Hester, Susan, Wehmas, Leah, Mari, Bernard, Barby, Pascal, Lacoux, Caroline, Fassy, Julien, Vial, Pablo, Vial, Cecilia, Martinez, Jose R W, Oladipo, Olusola Olalekan, Inuwa, Bitrus, Shittu, Ismaila, Meseko, Clement A, Chammas, Roger, Santos, Carlos Ferreira, Dionísio, Thiago José, Garbieri, Thais Francini, Parisi, Viviane Aparecida, Mendes-Correa, Maria Cassia, de Paula, Anderson V, Romano, Camila M, Góes, Luiz Gustavo Bentim, Minoprio, Paola, Campos, Angelica C, Cunha, Marielton P, Vilela, Ana Paula P, Nyirenda, Tonney, Mkakosya, Rajhab Sawasawa, Muula, Adamson S, Dumm, Rebekah E, Harris, Rebecca M, Mitchell, Constance A, Pettit, Syril, Botten, Jason, Jerome, Keith R

“…Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is used worldwide to test and trace the spread of severe acute respiratory syndrome…”
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KRAS and NRAS Translation Is Increased upon MEK Inhibitors-Induced Processing Bodies Dissolution by Vidal-Cruchez, Olivia, Nicolini, Victoria J, Rete, Tifenn, Jacquet, Karine, Rezzonico, Roger, Lacoux, Caroline, Domdom, Marie-Angela, Roméo, Barnabé, Roux, Jérémie, Hubstenberger, Arnaud, Mari, Bernard, Mograbi, Baharia, Hofman, Paul, Brest, Patrick

“…Overactivation of the mitogen-activated protein kinase (MAPK) pathway is a critical driver of many human cancers. However, therapies directly targeting this…”
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Molecular dynamics simulations show how the FMRP Ile304Asn mutation destabilizes the KH2 domain structure and affects its function by Di Marino, Daniele, Achsel, Tilmann, Lacoux, Caroline, Falconi, Mattia, Bagni, Claudia

“…Mutations or deletions of FMRP, involved in the regulation of mRNA metabolism in brain, lead to the Fragile X syndrome (FXS), the most frequent form of…”
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Regulatory crosstalk between type I and type II toxin-antitoxin systems in the human pathogen Enterococcus faecalis by Wessner, Françoise, Lacoux, Caroline, Goeders, Nathalie, Fouquier d'Hérouel, Aymeric, Matos, Renata, Serror, Pascale, Van Melderen, Laurence, Repoila, Francis

“…We discovered a chromosomal locus containing 2 toxin-antitoxin modules (TAs) with an antisense transcriptional organization in the E. faecalis clinical isolate…”
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Overexpression of Enterococcus faecalis elr operon protects from phagocytosis by Cortes-Perez, Naima G, Dumoulin, Romain, Gaubert, Stéphane, Lacoux, Caroline, Bugli, Francesca, Martin, Rebeca, Chat, Sophie, Piquand, Kevin, Meylheuc, Thierry, Langella, Philippe, Sanguinetti, Maurizio, Posteraro, Brunella, Rigottier-Gois, Lionel, Serror, Pascale

“…Mechanisms underlying the transition from commensalism to virulence in Enterococcus faecalis are not fully understood. We previously identified the…”
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Molecular dynamics simulations show how the FMRP II304Asn mutation destabilizes the KH2 domain structure and affects its function by Di Marino, Daniele, Achsel, Tilmann, Lacoux, Caroline, Falconi, Mattia, Bagni, Claudia

“…Mutations or deletions of FMRP, involved in the regulation of mRNA metabolism in brain, lead to the Fragile X syndrome (FXS), the most frequent form of…”
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The Brain Cytoplasmic RNA BC1 Regulates Dopamine D2 Receptor-Mediated Transmission in the Striatum by Centonze, Diego, Rossi, Silvia, Napoli, Ilaria, Mercaldo, Valentina, Lacoux, Caroline, Ferrari, Francesca, Ciotti, Maria Teresa, De Chiara, Valentina, Prosperetti, Chiara, Maccarrone, Mauro, Fezza, Filomena, Calabresi, Paolo, Bernardi, Giorgio, Bagni, Claudia

“…Dopamine D(2) receptor (D(2)DR)-mediated transmission in the striatum is remarkably flexible, and changes in its efficacy have been heavily implicated in a…”
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The Brain Cytoplasmic RNA BC1 Regulates Dopamine D 2 Receptor-Mediated Transmission in the Striatum by Centonze, Diego, Rossi, Silvia, Napoli, Ilaria, Mercaldo, Valentina, Lacoux, Caroline, Ferrari, Francesca, Ciotti, Maria Teresa, De Chiara, Valentina, Prosperetti, Chiara, Maccarrone, Mauro, Fezza, Filomena, Calabresi, Paolo, Bernardi, Giorgio, Bagni, Claudia

“…Dopamine D 2 receptor (D 2 DR)-mediated transmission in the striatum is remarkably flexible, and changes in its efficacy have been heavily implicated in a…”
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The Brain Cytoplasmic RNA BC1 Regulates Dopamine D sub(2) Receptor-Mediated Transmission in the Striatum by Centonze, Diego, Rossi, Silvia, Napoli, Ilaria, Mercaldo, Valentina, Lacoux, Caroline, Ferrari, Francesca, Ciotti, Maria Teresa, De Chiara, Valentina, Prosperetti, Chiara, Maccarrone, Mauro, Fezza, Filomena, Calabresi, Paolo, Bernardi, Giorgio, Bagni, Claudia

“…Dopamine D sub(2) receptor (D sub(2)DR)-mediated transmission in the striatum is remarkably flexible, and changes in its efficacy have been heavily implicated…”
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