Search Results - "Lacombe, Véronique A"

Dysregulation of insulin-sensitive glucose transporters during insulin resistance-induced atrial fibrillation by Maria, Zahra, Campolo, Allison R., Scherlag, Benjamin J., Ritchey, Jerry W., Lacombe, Véronique A.

“…Diabetes has been identified as major risk factor for atrial fibrillation (AF). Although glucose and insulin disturbances during diabetes may affect atrial…”
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Impact of Delta SARS-CoV-2 Infection on Glucose Metabolism: Insights on Host Metabolism and Virus Crosstalk in a Feline Model by Rochowski, Matthew T, Jayathilake, Kaushalya, Balcerak, John-Michael, Selvan, Miruthula Tamil, Gunasekara, Sachithra, Miller, Craig, Rudd, Jennifer M, Lacombe, Véronique A

“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes enhanced mortality in people with metabolic and cardiovascular diseases. Other highly…”
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Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes by Lacombe, Véronique A, Viatchenko-Karpinski, Serge, Terentyev, Dmitry, Sridhar, Arun, Emani, Sitaramesh, Bonagura, John D, Feldman, David S, Györke, Sandor, Carnes, Cynthia A

“…Isolated diastolic dysfunction is found in almost half of asymptomatic patients with well-controlled diabetes and may precede diastolic heart failure. However,…”
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Glial Growth Factor 2 Regulates Glucose Transport in Healthy Cardiac Myocytes and During Myocardial Infarction via an Akt-Dependent Pathway by Shoop, Shanell, Maria, Zahra, Campolo, Allison, Rashdan, Nabil, Martin, Dominic, Lovern, Pamela, Lacombe, Véronique A

“…Neuregulin (NRG), a paracrine factor in myocytes, promotes cardiac development via the ErbB receptors. NRG-1β also improves cardiac function and cell survival…”
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Advanced glycation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling by Kranstuber, Allyson L, Del Rio, Carlos, Biesiadecki, Brandon J, Hamlin, Robert L, Ottobre, Joseph, Gyorke, Sandor, Lacombe, Véronique A

“…Diabetic heart disease is a distinct clinical entity that can progress to heart failure and sudden death. However, the mechanisms responsible for the…”
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Investigating the Relationship Between Cardiac Function and Insulin Sensitivity in Horses: A Pilot Study by Williams, Natasha J., Furr, Martin, Navas de Solis, Cristobal, Campolo, Allison, Davis, Michael, Lacombe, Véronique A.

“…Metabolic syndrome in humans is commonly associated with cardiovascular dysfunction, including atrial fibrillation and left ventricular diastolic dysfunction…”
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Insulin Treatment Reduces Susceptibility to Atrial Fibrillation in Type 1 Diabetic Mice by Maria, Zahra, Campolo, Allison R, Scherlag, Benjamin J, Ritchey, Jerry W, Lacombe, Véronique A

“…Diabetes has been identified as an independent risk factor for atrial fibrillation (AF), the most common chronic cardiac arrhythmia. Whether or not glucose and…”
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Differential Proteomic Expression of Equine Cardiac and Lamellar Tissue During Insulin-Induced Laminitis by Campolo, Allison, Frantz, Matthew W., de Laat, Melody A., Hartson, Steven D., Furr, Martin O., Lacombe, Véronique A.

“…Endocrinopathic laminitis is pathologically similar to the multi-organ dysfunction and peripheral neuropathy found in human patients with metabolic syndrome…”
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Expression and Regulation of Facilitative Glucose Transporters in Equine Insulin-Sensitive Tissue: From Physiology to Pathology by Lacombe, Véronique A.

“…Glucose uptake is the rate-limiting step in glucose utilization in mammalians and is tightly regulated by a family of specialized proteins, called the…”
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Hyperinsulinemia Down-Regulates TLR4 Expression in the Mammalian Heart by de Laat, Melody A, Gruntmeir, Kaylynn J, Pollitt, Christopher C, McGowan, Catherine M, Sillence, Martin N, Lacombe, Véronique A

“…Toll-like receptors (TLR) are key regulators of innate immune and inflammatory responses and their activation is linked to impaired glucose metabolism during…”
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Diabetes Alters the Expression and Translocation of the Insulin-Sensitive Glucose Transporters 4 and 8 in the Atria by Maria, Zahra, Campolo, Allison R, Lacombe, Veronique A

“…Although diabetes has been identified as a major risk factor for atrial fibrillation, little is known about glucose metabolism in the healthy and diabetic…”
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Quantification of Cell-Surface Glucose Transporters in the Heart Using a Biotinylated Photolabeling Assay by Maria, Zahra, Lacombe, Véronique A

“…The biotinylated photolabeling assay enables quantification of cell-surface glucose transporters (GLUTs). This technique has been successfully applied to…”
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Equine insulin dysregulation causes tissue specific alterations of proinflammatory cytokines and acute phase proteins in a NF-kB independent manner by Jayathilake, W.M.N.K., Furr, Martin, Risco, Carlos, Lacombe, Véronique A.

“…Similar to human diabetes, equine metabolic syndrome (EMS) causes insulin dysregulation leading to debilitating sequela including laminitis. The…”
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Diabetes Causes Significant Alterations in Pulmonary Glucose Transporter Expression by Campolo, Allison, Maria, Zahra, Lacombe, Véronique A

“…Diabetes has been identified as a significant and independent risk factor for the development or increased severity of respiratory infections. However, the…”
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Up-regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2 by Kalyanasundaram, Anuradha, Lacombe, Véronique A, Belevych, Andriy E, Brunello, Lucia, Carnes, Cynthia A, Janssen, Paul M L, Knollmann, Bjørn C, Periasamy, Muthu, Gyørke, Sandor

“…Although aberrant Ca(2+) release (i.e. Ca(2+) 'leak') from the sarcoplasmic reticulum (SR) through cardiac ryanodine receptors (RyR2) is linked to heart…”
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Up-regulation of sarcoplasmic reticulum Ca2+ uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2 by Kalyanasundaram, Anuradha, Lacombe, Véronique A., Belevych, Andriy E., Brunello, Lucia, Carnes, Cynthia A., Janssen, Paul M.L., Knollmann, Bjørn C., Periasamy, Muthu, Gyørke, Sandor

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GLUT12 functions as a basal and insulin-independent glucose transporter in the heart by Waller, Amanda P, George, Michael, Kalyanasundaram, Anuradha, Kang, Chen, Periasamy, Muthu, Hu, Keli, Lacombe, Véronique A

“…Glucose uptake from the bloodstream is the rate-limiting step in whole body glucose utilization, and is regulated by a family of membrane proteins called…”
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Sarcoplasmic reticulum Ca2+ ATPase pump is a major regulator of glucose transport in the healthy and diabetic heart by Waller, Amanda P., Kalyanasundaram, Anuradha, Hayes, Summer, Periasamy, Muthu, Lacombe, Véronique A.

“…Despite intensive research, the pathways that mediate calcium (Ca2+)-stimulated glucose transport in striated muscle remain elusive. Since the sarcoplasmic…”
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Loss of Toll-Like Receptor 4 Function Partially Protects against Peripheral and Cardiac Glucose Metabolic Derangements During a Long-Term High-Fat Diet by Jackson, Ellen E, Rendina-Ruedy, Elisabeth, Smith, Brenda J, Lacombe, Veronique A

“…Diabetes is a chronic inflammatory disease that carries a high risk of cardiovascular disease. However, the pathophysiological link between these disorders is…”
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Chronic heart failure selectively induces regional heterogeneity of insulin-responsive glucose transporters by Ware, Bruce, Bevier, Marie, Nishijima, Yoshinori, Rogers, Suzanne, Carnes, Cynthia A, Lacombe, Véronique A

“…Glucose uptake across the sarcolemma is regulated by a family of membrane proteins called glucose transporters (GLUTs), which includes GLUT4 (the major cardiac…”
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