Search Results - "Lacombe, V"

Polyreactivity of antibodies from different B-cell subpopulations is determined by distinct sequence patterns of variable region by Lecerf, Maxime, Lacombe, Robin V, Dimitrov, Jordan D

“…An antibody molecule that can bind to multiple distinct antigens is defined as polyreactive. In the present study, we performed statistical analyses to assess…”
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Temperature sensitivity of bat antibodies links metabolic state of bats with antigen-recognition diversity by Toshkova, Nia, Zhelyzkova, Violeta, Reyes-Ruiz, Alejandra, Haerens, Eline, de Castro Deus, Marina, Lacombe, Robin V., Lecerf, Maxime, Gonzalez, Gaelle, Jouvenet, Nolwenn, Planchais, Cyril, Dimitrov, Jordan D.

“…The bat immune system features multiple unique properties such as dampened inflammatory responses and increased tissue protection, explaining their long…”
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Prolonged hyperinsulinemia increases the production of inflammatory cytokines in equine digital lamellae but not in striated muscle by Jayathilake, W.M.N.K., de Laat, M.A., Furr, M., Risco, C., Lacombe, V.A.

“…Hyperinsulinemia is the key feature of equine metabolic syndrome (EMS) which leads to debilitating sequelae. Hyperinsulinemia-associated laminitis (HAL) is one…”
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Treatment of ITP and AIHA in CVID: A systematic literature review by Lacombe, V, Lozac'h, P, Orvain, C, Lavigne, C, Miot, C, Pellier, I, Urbanski, G

“…Ten to 15% of common variable immunodeficiencies (CVID) develop auto-immune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Treatment is based on…”
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Distribution and predictive factors of seizure types in 104 cases by Lacombe, V. A, Mayes, M, Mosseri, S, Reed, S. M, Ou, T. H

“…REASONS FOR PERFORMING THE STUDY: Although many studies have been performed to classify seizures by type in man and small animals, a similar study in horses is…”
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Diagnostic utility of computed tomography imaging in equine intracranial conditions by Lacombe, V.A, Sogaro-Robinson, C, Reed, S.M

“…Summary Reasons for performing study: The use of computer tomography (CT) and contrast‐enhanced CT (CCT) to image the head is common. However, the validity of…”
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Challenges associated with the diagnosis and treatment of parasitic encephalitis by Lacombe, V. A.

“…See also article by Wilford et al…”
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Novel link between inflammation and impaired glucose transport during equine insulin resistance by Waller, A.P., Huettner, L., Kohler, K., Lacombe, V.A.

“…Although insulin resistance (IR) has been increasingly recognized in horses, a clear understanding of its pathophysiology is lacking. The purpose of the…”
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Epilepsy in horses: Aetiological classification and predictive factors by Lacombe, V. A., Mayes, M., Mosseri, S., Reed, S. M., Fenner, W. R., Ou, H. T.

“…Summary Reasons for performing the study: In contrast with reports in man and small animals, a systematic classification of seizures in horses is lacking…”
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Prolonged hyperinsulinemia affects metabolic signal transduction markers in a tissue specific manner by Campolo, A., de Laat, M.A., Keith, L., Gruntmeir, K.J., Lacombe, V.A.

“…Insulin dysregulation is common in horses although the mechanisms of metabolic dysfunction are poorly understood. We hypothesized that insulin signaling in…”
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impact of prolonged hyperinsulinaemia on glucose transport in equine skeletal muscle and digital lamellae by de Laat, M. A., Clement, C. K., Sillence, M. N., McGowan, C. M., Pollitt, C. C., Lacombe, V. A.

“…REASONS FOR PERFORMING STUDY: An increased incidence of metabolic disease in horses has led to heightened recognition of the pathological consequences of…”
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Naturally occurring compensated insulin resistance selectively alters glucose transporters in visceral and subcutaneous adipose tissues without change in AS160 activation by Waller, A.P., Kohler, K., Burns, T.A., Mudge, M.C., Belknap, J.K., Lacombe, V.A.

“…Although the importance of adipose tissue (AT) glucose transport in regulating whole-body insulin sensitivity is becoming increasingly evident and insulin…”
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Insulin Resistance Selectively Alters Cell-Surface Glucose Transporters but not their Total Protein Expression in Equine Skeletal Muscle by Waller, A.P, Burns, T.A, Mudge, M.C, Belknap, J.K, Lacombe, V.A

“…Background: Insulin resistance (IR) has been widely recognized in humans, and more recently in horses, but its underlying mechanisms are still not well…”
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AICAR administration affects glucose metabolism by upregulating the novel glucose transporter, GLUT8, in equine skeletal muscle by de Laat, M.A., Robinson, M.A., Gruntmeir, K.J., Liu, Y., Soma, L.R., Lacombe, V.A.

“…•The role of AMPK in regulating glucose metabolism in horses is unknown.•AICAR administration induces transient hypoglycaemia and hyperinsulinaemia in…”
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Toll-like receptor and pro-inflammatory cytokine expression during prolonged hyperinsulinaemia in horses: Implications for laminitis by de Laat, M.A., Clement, C.K., McGowan, C.M., Sillence, M.N., Pollitt, C.C., Lacombe, V.A.

“…Equine laminitis, a disease of the lamellar structure of the horse's hoof, can be incited by numerous factors that include inflammatory and metabolic…”
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Onset of immunity in kittens after vaccination with a non-adjuvanted vaccine against feline panleucopenia, feline calicivirus and feline herpesvirus by Jas, D., Aeberlé, C., Lacombe, V., Guiot, A.L., Poulet, H.

“…The induction of a quick onset of immunity against feline parvovirus (FPV), feline herpesvirus (FHV) and feline calicivirus (FCV) is critical both in young…”
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The plateau outward current in canine ventricle, sensitive to 4‐aminopyridine, is a constitutive contributor to ventricular repolarization by Sridhar, A, Cunha, D N Q, Lacombe, V A, Zhou, Q, Fox, J J, Hamlin, R L, Carnes, C A

“…Background and purpose: IKur (Ultra‐rapid delayed rectifier current) has μM sensitivity to 4‐aminopyridine (4‐AP) and is an important modulator of the plateau…”
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Immature and mature antibodies as defenders against cancer by Lacombe, Robin V., Sibéril, Sophie, Dimitrov, Jordan D.

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High intensity exercise conditioning increases accumulated oxygen deficit of horses by HINCHCLIFF, K. W., LAUDERDALE, M. A., DUTSON, J., GEOR, R. J., LACOMBE, V. A., TAYLOR, L. E.

“…Summary High intensity exercise is associated with production of energy by both aerobic and anaerobic metabolism. Conditioning by repeated exercise increases…”
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AN EQUINE PROTOZOAL MYELOENCEPHALITIS CHALLENGE MODEL TESTING A SECOND TRANSPORT AFTER INOCULATION WITH SARCOCYSTIS NEURONA SPOROCYSTS by Saville, W. J A, Sofaly, C. D, Reed, S. M, Dubey, J. P, Oglesbee, M. J, Lacombe, V. A, Keene, R. O, Gugisberg, K. M, Swensen, S. W, Shipley, R. D, Chiang, Y-W, Chu, H. J, Ng, T

“…Previous challenge studies performed at Ohio State University involved a transport-stress model where the study animals were dosed with Sarcocystis neurona…”
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