Search Results - "Lacombe, Marie‐Lise"

The mitochondrial nucleoside diphosphate kinase (NDPK-D/NME4), a moonlighting protein for cell homeostasis by Lacombe, Marie-Lise, Tokarska-Schlattner, Malgorzata, Boissan, Mathieu, Schlattner, Uwe

“…Mitochondrial nucleoside diphosphate kinase (NDPK-D; synonyms: NME4, NM23-H4) represents the major mitochondrial NDP kinase. The homohexameric complex emerged…”
Get full text

Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance by Lodillinsky, Catalina, Fuhrmann, Laetitia, Irondelle, Marie, Pylypenko, Olena, Li, Xiao-Yan, Bonsang-Kitzis, Hélène, Reyal, Fabien, Vacher, Sophie, Calmel, Claire, De Wever, Olivier, Bièche, Ivan, Lacombe, Marie-Lise, Eiján, Ana Maria, Houdusse, Anne, Vincent-Salomon, Anne, Weiss, Stephen J., Chavrier, Philippe, Boissan, Mathieu

“…Membrane Type 1 Matrix Metalloprotease (MT1-MMP) contributes to the invasive progression of breast cancers by degrading extracellular matrix tissues…”
Get full text

mammalian Nm23/NDPK family: from metastasis control to cilia movement by Boissan, Mathieu, Dabernat, Sandrine, Peuchant, Evelyne, Schlattner, Uwe, Lascu, Ioan, Lacombe, Marie-Lise

“…Nucleoside diphosphate kinases (NDPK) are encoded by the NME genes, also called NM23. They catalyze the transfer of γ-phosphate from nucleoside triphosphates…”
Get full text

The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor by Lacombe, Marie-Lise, Lamarche, Frederic, De Wever, Olivier, Padilla-Benavides, Teresita, Carlson, Alyssa, Khan, Imran, Huna, Anda, Vacher, Sophie, Calmel, Claire, Desbourdes, Céline, Cottet-Rousselle, Cécile, Hininger-Favier, Isabelle, Attia, Stéphane, Nawrocki-Raby, Béatrice, Raingeaud, Joël, Machon, Christelle, Guitton, Jérôme, Le Gall, Morgane, Clary, Guilhem, Broussard, Cedric, Chafey, Philippe, Thérond, Patrice, Bernard, David, Fontaine, Eric, Tokarska-Schlattner, Malgorzata, Steeg, Patricia, Bièche, Ivan, Schlattner, Uwe, Boissan, Mathieu

“…Mitochondrial nucleoside diphosphate kinase (NDPK-D, NME4, NM23-H4) is a multifunctional enzyme mainly localized in the intermembrane space, bound to the inner…”
Get full text

Metastasis suppressor NM23 limits oxidative stress in mammals by preventing activation of stress‐activated protein kinases/JNKs through its nucleoside diphosphate kinase activity by Peuchant, Evelyne, Bats, Marie‐Lise, Moranvillier, Isabelle, Lepoivre, Michel, Guitton, Jérôme, Wendum, Dominique, Lacombe, Marie‐Lise, Moreau‐Gaudry, François, Boissan, Mathieu, Dabernat, Sandrine

“…NME1 (nonmetastatic expressed 1) gene, which encodes nucleoside diphosphate kinase (NDPK) A [also known as nonmetastatic clone 23 (NM23)‐H1 in humans and…”
Get full text

Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells by BOISSAN, Mathieu, DE WEVER, Olivier, BRACKE, Marc, CHAVRIER, Philippe, GESPACH, Christian, LACOMBE, Marie-Lise, LIZARRAGA, Floria, WENDUM, Dominique, POINCLOUX, Renaud, CHIGNARD, Nicolas, DESBOIS-MOUTHON, Christèle, DUFOUR, Sylvie, NAWROCKI-RABY, Béatrice, BIREMBAUT, Philippe

“…Loss of NM23-H1 expression correlates with the degree of metastasis and with unfavorable clinical prognosis in several types of human carcinoma. However, the…”
Get full text

CXCR7 is up-regulated in human and murine hepatocellular carcinoma and is specifically expressed by endothelial cells by Monnier, Justin, Boissan, Mathieu, L’Helgoualc’h, Annie, Lacombe, Marie-Lise, Turlin, Bruno, Zucman-Rossi, Jessica, Théret, Nathalie, Piquet-Pellorce, Claire, Samson, Michel

“…Abstract Development of hepatocellular carcinoma (HCC) is a complex and progressive disease that involves cycles of liver cell death, inflammation, and tissue…”
Get full text

KIF20A mRNA and Its Product MKlp2 Are Increased During Hepatocyte Proliferation and Hepatocarcinogenesis by Gasnereau, Isabelle, Boissan, Mathieu, Margall-Ducos, Germain, Couchy, Gabrielle, Wendum, Dominique, Bourgain-Guglielmetti, Florence, Desdouets, Chantal, Lacombe, Marie-Lise, Zucman-Rossi, Jessica, Sobczak-Thépot, Joëlle

“…Mitotic kinesin-like protein 2 (MKlp2), a microtubule-associated motor, is required during mitosis exit for the final step of cytokinesis. It also contributes…”
Get full text

The Nucleoside Diphosphate Kinase D (NM23-H4) Binds the Inner Mitochondrial Membrane with High Affinity to Cardiolipin and Couples Nucleotide Transfer with Respiration by Tokarska-Schlattner, Malgorzata, Boissan, Mathieu, Munier, Annie, Borot, Caroline, Mailleau, Christiane, Speer, Oliver, Schlattner, Uwe, Lacombe, Marie-Lise

“…Nucleoside diphosphate kinase (NDPK/Nm23), responsible for intracellular di- and triphosphonucleoside homeostasis, plays multiple roles in cellular energetics,…”
Get full text

The NDPK/NME superfamily: state of the art by Boissan, Mathieu, Schlattner, Uwe, Lacombe, Marie-Lise

“…Nucleoside diphosphate kinases (NDPK) are nucleotide metabolism enzymes encoded by NME genes (also called NM23). Given the fact that not all NME-encoded…”
Get full text

Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2 by HORAK, Christine E, JONG HEUN LEE, MELTZER, Paul S, STEEG, Patricia S, ELKAHLOUN, Abdel G, BOISSAN, Mathieu, DUMONT, Sylvie, MAGA, Tara K, ARNAUD-DABERNAT, Sandrine, PALMIERI, Diane, STETLER-STEVENSON, William G, LACOMBE, Marie-Lise

“…Exogenous overexpression of the metastasis suppressor gene Nm23-H1 reduces the metastatic potential of multiple types of cancer cells and suppresses in vitro…”
Get full text

Mitochondrial NM23-H4/NDPK-D: a bifunctional nanoswitch for bioenergetics and lipid signaling by Schlattner, Uwe, Tokarska-Schlattner, Malgorzata, Epand, Richard M., Boissan, Mathieu, Lacombe, Marie-Lise, Klein-Seetharaman, Judith, Kagan, Valerian E.

“…A novel paradigm for the function of the mitochondrial nucleoside diphosphate kinase NM23-H4/NDPK-D is proposed: acting as a bifunctional nanoswitch in…”
Get full text

Overexpression of Insulin Receptor Substrate-2 in Human and Murine Hepatocellular Carcinoma by Boissan, Mathieu, Beurel, Eléonore, Wendum, Dominique, Rey, Colette, Lécluse, Yann, Housset, Chantal, Lacombe, Marie-Lise, Desbois-Mouthon, Christèle

“…Deregulations in insulin and insulin-like growth factor (IGF) pathways may contribute to hepatocellular carcinoma. Although intracellular insulin receptor…”
Get full text

Nm23/NDP kinases in hepatocellular carcinoma by Boissan, Mathieu, Lacombe, Marie-Lise

“…One of the most aggressive cancers is hepatocellular carcinoma, which is associated with a very poor patient outcome due to a high recurrence rate and…”
Get full text

Nm23-H1 homologs suppress tumor cell motility and anchorage independent growth by McDermott, William G., Boissan, Mathieu, Lacombe, Marie-Lise, Steeg, Patricia S., Horak, Christine E.

“…Nm23-H1 suppresses metastasis, as well as in vitro cell motility, invasion and anchorage independent growth, in a variety of cancer models. Eight human…”
Get full text

NME4/nucleoside diphosphate kinase D in cardiolipin signaling and mitophagy by Schlattner, Uwe, Tokarska-Schlattner, Malgorzata, Epand, Richard M, Boissan, Mathieu, Lacombe, Marie-Lise, Kagan, Valerian E

“…Mitophagy is an emerging paradigm for mitochondrial quality control and cell homeostasis. Dysregulation of mitophagy can lead to human pathologies such as…”
Get full text

nm23: Unraveling its biological function in cell differentiation by Lombardi, Daniela, Lacombe, Marie-Lise, Paggi, Marco G.

“…Tumor suppressor genes have a pivotal role in normal cells regulating cell cycle processes negatively. Furthermore, the inhibition of cell proliferation is a…”
Get full text

Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling by Boissan, Mathieu, Montagnac, Guillaume, Shen, Qinfang, Griparic, Lorena, Guitton, Jérôme, Romao, Maryse, Sauvonnet, Nathalie, Lagache, Thibault, Lascu, Ioan, Raposo, Graça, Desbourdes, Céline, Schlattner, Uwe, Lacombe, Marie-Lise, Polo, Simona, van der Bliek, Alexander M., Roux, Aurélien, Chavrier, Philippe

“…Dynamin superfamily molecular motors use guanosine triphosphate (GTP) as a source of energy for membrane-remodeling events. We found that knockdown of…”
Get full text

The Human nm23-H4 Gene Product Is a Mitochondrial Nucleoside Diphosphate Kinase by Milon, Laurence, Meyer, Philippe, Chiadmi, Mohamed, Munier, Annie, Johansson, Magnus, Karlsson, Anna, Lascu, Ioan, Capeau, Jacqueline, Janin, Joël, Lacombe, Marie-Lise

“…We demonstrate here the catalytic activity and subcellular localization of the Nm23-H4 protein, product ofnm23-H4, a new member of the humannm23/nucleoside…”
Get full text

Mitochondrial cardiolipin/phospholipid trafficking: The role of membrane contact site complexes and lipid transfer proteins by Schlattner, Uwe, Tokarska-Schlattner, Malgorzata, Rousseau, Denis, Boissan, Mathieu, Mannella, Carmen, Epand, Richard, Lacombe, Marie-Lise

“…•Cardiolipin is synthesized in mitochondria, secondarily modified, and shows heterogeneous distribution.•Cardiolipin/phospholipids move between the two…”
Get full text