Search Results - "Lacko, Lauretta A"

SARS-CoV-2 infection induces beta cell transdifferentiation by Tang, Xuming, Uhl, Skyler, Zhang, Tuo, Xue, Dongxiang, Li, Bo, Vandana, J. Jeya, Acklin, Joshua A., Bonnycastle, Lori L., Narisu, Narisu, Erdos, Michael R., Bram, Yaron, Chandar, Vasuretha, Chong, Angie Chi Nok, Lacko, Lauretta A., Min, Zaw, Lim, Jean K., Borczuk, Alain C., Xiang, Jenny, Naji, Ali, Collins, Francis S., Evans, Todd, Liu, Chengyang, tenOever, Benjamin R., Schwartz, Robert E., Chen, Shuibing

“…Recent clinical data have suggested a correlation between coronavirus disease 2019 (COVID-19) and diabetes. Here, we describe the detection of SARS-CoV-2 viral…”
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Human organoid models to study SARS-CoV-2 infection by Han, Yuling, Yang, Liuliu, Lacko, Lauretta A., Chen, Shuibing

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Druggable targets and therapeutic development for COVID-19 by Duan, Xiaohua, Lacko, Lauretta A., Chen, Shuibing

“…Coronavirus disease (COVID-19), which is caused by SARS-CoV-2, is the biggest challenge to the global public health and economy in recent years. Until now,…”
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Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells by Tan, Lei, Lacko, Lauretta A., Zhou, Ting, Tomoiaga, Delia, Hurtado, Romulo, Zhang, Tuo, Sevilla, Ana, Zhong, Aaron, Mason, Christopher E, Noggle, Scott, Evans, Todd, Stuhlmann, Heidi, Schwartz, Robert E., Chen, Shuibing

“…Zika virus (ZIKV) infection results in an increased risk of spontaneous abortion and poor intrauterine growth although the underlying mechanisms remain…”
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A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin by Gu, Wei, Huang, Xiaofeng, Singh, Pratik N. P., Li, Sanlan, Lan, Ying, Deng, Min, Lacko, Lauretta A., Gomez-Salinero, Jesus M., Rafii, Shahin, Verzi, Michael P., Shivdasani, Ramesh A., Zhou, Qiao

“…Plasticity among cell lineages is a fundamental, but poorly understood, property of regenerative tissues. In the gut tube, the small intestine absorbs…”
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Human organoid models to study SARS-CoV-2 infection by Han, Yuling, Yang, Liuliu, Lacko, Lauretta A., Chen, Shuibing

“…Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history…”
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Endothelial Cells Control Pancreatic Cell Fate at Defined Stages through EGFL7 Signaling by Kao, Der-I, Lacko, Lauretta A., Ding, Bi-Sen, Huang, Chen, Phung, Kathleen, Gu, Guoqiang, Rafii, Shahin, Stuhlmann, Heidi, Chen, Shuibing

“…Although endothelial cells have been shown to affect mouse pancreatic development, their precise function in human development remains unclear. Using a…”
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Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation by Vandana, J. Jeya, Manrique, Cassandra, Lacko, Lauretta A., Chen, Shuibing

“…Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a new era for disease modeling and drug discovery. Over the past decade,…”
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Derivation and characterization of a UCP1 reporter human ES cell line by Mukherjee, Suranjit, Zhang, Tuo, Lacko, Lauretta A., Tan, Lei, Xiang, Jenny Zhaoying, Butler, Jason M., Chen, Shuibing

“…Interest in human brown fat as a novel therapeutic target to tackle the growing obesity and diabetes epidemic has increased dramatically in recent years. While…”
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Isogenic human trophectoderm cells demonstrate the role of NDUFA4 and associated variants in ZIKV infection by Yang, Liuliu, Han, Yuling, Zhou, Ting, Lacko, Lauretta A., Saeed, Mohsan, Tan, Christina, Danziger, Ron, Zhu, Jiajun, Zhao, Zeping, Cahir, Clare, Giani, Alice Maria, Li, Yang, Dong, Xue, Moroziewicz, Dorota, Paull, Daniel, Chen, Zhengming, Zhong, Aaron, Noggle, Scott A., Rice, Charles M., Qi, Qibin, Evans, Todd, Chen, Shuibing

“…Population-based genome-wide association studies (GWAS) normally require a large sample size, which can be labor intensive and costly. Recently, we reported a…”
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Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis by Vandana, J Jeya, Lacko, Lauretta A, Chen, Shuibing

“…Using an automatic microfluidics droplet platform, Ding et al. successfully replicated the tumor micro-environment by generating micro-organospheres, which…”
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Phenotypic technologies in stem cell biology by Vandana, J Jeya, Lacko, Lauretta A, Chen, Shuibing

“…The high-throughput phenotypic screen (HTPS) has become an emerging technology to discover synthetic small molecules that regulate stem cell fates. Here, we…”
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SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells by Han, Yuling, Zhu, Jiajun, Yang, Liuliu, Nilsson-Payant, Benjamin E., Hurtado, Romulo, Lacko, Lauretta A., Sun, Xiaolu, Gade, Aravind R., Higgins, Christina A., Sisso, Whitney J., Dong, Xue, Wang, Maple, Chen, Zhengming, Ho, David D., Pitt, Geoffrey S., Schwartz, Robert E., tenOever, Benjamin R., Evans, Todd, Chen, Shuibing

“…Increasing evidence suggests that cardiac arrhythmias are frequent clinical features of coronavirus disease 2019 (COVID-19). Sinus node damage may lead to…”
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Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with Egfl7 loss of function by Lacko, Lauretta A, Hurtado, Romulo, Hinds, Samantha, Poulos, Michael G, Butler, Jason M, Stuhlmann, Heidi

“…EGFL7 is a secreted angiogenic factor produced by embryonic endothelial cells. To understand its role in placental development, we established a novel knockout…”
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Organoid-based chemical approach to dissect the mechanism controlling cellular dynamics by Lacko, Lauretta A, Chen, Shuibing

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miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta by Sharma, Abhijeet, Lacko, Lauretta A., Argueta, Lissenya B., Glendinning, Michael D., Stuhlmann, Heidi

“…A functional placenta develops through a delicate interplay of its vascular and trophoblast compartments. We have identified a previously unknown expression…”
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SARS-CoV-2 infection causes dopaminergic neuron senescence by Yang, Liuliu, Kim, Tae Wan, Han, Yuling, Nair, Manoj S, Harschnitz, Oliver, Zhu, Jiajun, Wang, Pengfei, Koo, So Yeon, Lacko, Lauretta A, Chandar, Vasuretha, Bram, Yaron, Zhang, Tuo, Zhang, Wei, He, Feng, Pan, Chendong, Wu, Junjie, Huang, Yaoxing, Evans, Todd, van der Valk, Paul, Titulaer, Maarten J, Spoor, Jochem K H, Furler O'Brien, Robert L, Bugiani, Marianna, D J Van de Berg, Wilma, Schwartz, Robert E, Ho, David D, Studer, Lorenz, Chen, Shuibing

“…COVID-19 patients commonly present with signs of central nervous system and/or peripheral nervous system dysfunction. Here, we show that midbrain dopamine (DA)…”
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A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants by Han, Yuling, Tan, Lei, Zhou, Ting, Yang, Liuliu, Carrau, Lucia, Lacko, Lauretta A, Saeed, Mohsan, Zhu, Jiajun, Zhao, Zeping, Nilsson-Payant, Benjamin E, Lira Neto, Filipe Tenorio, Cahir, Clare, Giani, Alice Maria, Chai, Jin Chou, Li, Yang, Dong, Xue, Moroziewicz, Dorota, Paull, Daniel, Zhang, Tuo, Koo, Soyeon, Tan, Christina, Danziger, Ron, Ba, Qian, Feng, Lingling, Chen, Zhengming, Zhong, Aaron, Wise, Gilbert J, Xiang, Jenny Z, Wang, Hui, Schwartz, Robert E, tenOever, Benjamin R, Noggle, Scott A, Rice, Charles M, Qi, Qibin, Evans, Todd, Chen, Shuibing

“…Population-based studies to identify disease-associated risk alleles typically require samples from a large number of individuals. Here, we report a…”
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Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy by Argueta, Lissenya B., Lacko, Lauretta A., Bram, Yaron, Tada, Takuya, Carrau, Lucia, Rendeiro, André Figueiredo, Zhang, Tuo, Uhl, Skyler, Lubor, Brienne C., Chandar, Vasuretha, Gil, Cristianel, Zhang, Wei, Dodson, Brittany J., Bastiaans, Jeroen, Prabhu, Malavika, Houghton, Sean, Redmond, David, Salvatore, Christine M., Yang, Yawei J., Elemento, Olivier, Baergen, Rebecca N., tenOever, Benjamin R., Landau, Nathaniel R., Chen, Shuibing, Schwartz, Robert E., Stuhlmann, Heidi

“…The effect of SARS-CoV-2 infection on placental function is not well understood. Analysis of placentas from women who tested positive at delivery showed…”
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Increased circulating levels of Epidermal Growth Factor-like Domain 7 in pregnant women affected by preeclampsia by Massimiani, Micol, Lacko, Lauretta A., Burke Swanson, Clare S., Salvi, Silvia, Argueta, Lissenya B., Moresi, Sascia, Ferrazzani, Sergio, Gelber, Shari E., Baergen, Rebecca N., Toschi, Nicola, Campagnolo, Luisa, Stuhlmann, Heidi

“…Proper placental development is crucial to establish a successful pregnancy. Defective placentation is the major cause of several pregnancy complications,…”
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