Search Results - "Lackner, AA"

Central nervous system perivascular cells are immunoregulatory cells that connect the CNS with the peripheral immune system by Williams, Kenneth, Alvarez, Xavier, Lackner, Andrew A.

“…Perivascular cells are a heterogeneous population found in the central nervous system (CNS) and the peripheral nervous system (PNS). Several terms are used for…”
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Getting to the guts of HIV pathogenesis by Veazey, Ronald S, Lackner, Andrew A

“…Two groups have shown that, as in macaques infected with simian immunodeficiency virus (SIV), intestinal CD4(+) T cells are selectively and rapidly depleted in…”
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HIV swiftly guts the immune system by Veazey, Ronald S, Lackner, Andrew A

“…Two studies show that SIV directly kills massive numbers of immune cells in the gut within days of infection. The results come on the heels of similarly…”
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Perivascular macrophages are the primary cell type productively infected by simian immunodeficiency virus in the brains of macaques: implications for the neuropathogenesis of AIDS by Williams, K C, Corey, S, Westmoreland, S V, Pauley, D, Knight, H, deBakker, C, Alvarez, X, Lackner, A A

“…The macrophage is well established as a target of HIV and simian immunodeficiency virus (SIV) infection and a major contributor to the neuropathogenesis of…”
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Intestinal double‐positive CD4+CD8+ T cells are highly activated memory cells with an increased capacity to produce cytokines by Pahar, Bapi, Lackner, Andrew A., Veazey, Ronald S.

“…Peripheral blood and intestinal CD4+CD8+ double‐positive (DP) T cells have been described in several species including humans, but their function and…”
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Gastrointestinal Tract as a Major Site of CD4$^+$T Cell Depletion and Viral Replication in SIV Infection by Veazey, Ronald S., DeMaria, MaryAnn, Chalifoux, Laura V., Shvetz, Daniel E., Pauley, Douglas R., Knight, Heather L., Rosenzweig, Michael, Johnson, R. Paul, Desrosiers, Ronald C., Lackner, Andrew A.

“…Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4$^+$ T cells, a cell type that is abundant in the intestine…”
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Vaginal CD4+ T Cells Express High Levels of CCR5 and Are Rapidly Depleted in Simian Immunodeficiency Virus Infection by Veazey, Ronald S, Marx, Preston A, Lackner, Andrew A

“…Worldwide, the majority of human immunodeficiency virus–1 cases occur through heterosexual transmission, yet little is known regarding the phenotype of CD4+ T…”
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Molecular Epidemiology of Simian Immunodeficiency Virus SIVsm in U.S. Primate Centers Unravels the Origin of SIVmac and SIVstm by APETREI, Cristian, KAUR, Amitinder, WILLIAMS, Tessa, STAPRANS, Silvija, PLAUCHE, Gail, VEAZEY, Ronald S, MCCLURE, Harold, LACKNER, Andrew A, GORMUS, Bobby, ROBERTSON, David L, MARX, Preston A, LERCHE, Nicholas W, METZGER, Michael, PANDREA, Ivona, HARDCASTLE, Johnny, FALKENSTEIN, Shelley, BOHM, Rudolf, KOEHLER, Jeffrey, TRAINA-DORGE, Vicki

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HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages by Stevenson, M, Swingler, S, Mann, A, Jacqué, J.-M, Brichacek, B, Sasseville, V.G, Williams, K, Lackner, A.A, Janoff, E.N, Wang, R, Fisher, D

“…Infection of macrophage lineage cells is a feature of primate lentivirus replication, and several properties of primate lentiviruses seem to have evolved to…”
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The mucosal immune system: primary target for HIV infection and AIDS by Veazey, Ronald S, Marx, Preston A, Lackner, Andrew A

“…Despite intensive research, several questions remain regarding the pathogenesis of infection with HIV-1. Recently, it has been shown that simian…”
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Dynamics of CCR5 Expression by CD4+ T Cells in Lymphoid Tissues during Simian Immunodeficiency Virus Infection by Veazey, R S, Mansfield, K G, Tham, I C, Carville, A C, Shvetz, D E, Forand, A E, Lackner, A A

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Identifying the Target Cell in Primary Simian Immunodeficiency Virus (SIV) Infection: Highly Activated Memory CD4+ T Cells Are Rapidly Eliminated in Early SIV Infection In Vivo by Veazey, R S, Tham, I C, Mansfield, K G, DeMaria, M, Forand, A E, Shvetz, D E, Chalifoux, L V, Sehgal, P K, Lackner, A A

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Progesterone implants enhance SIV vaginal transmission and early virus load by Marx, P A, Spira, A I, Gettie, A, Dailey, P J, Veazey, R S, Lackner, A A, Mahoney, C J, Miller, C J, Claypool, L E, Ho, D D, Alexander, N J

“…Simian immunodeficiency virus (SIV) can cross the intact vaginal epithelium to establish a systemic infection in macaques (mac). Using this SIVmac model, we…”
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Kuru experiments triggered the emergence of pathogenic SIVmac by APETREI, Cristian, LERCHE, Nicholas W, PANDREA, Ivona, GORMUS, Bobby, SILVESTRI, Guido, KAUR, Amitinder, ROBERTSON, David L, HARDCASTLE, Johnny, LACKNER, Andrew A, MARX, Preston A

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Infectious Agent and Immune Response Characteristics of Chronic Enterocolitis in Captive Rhesus Macaques by SESTAK, Karol, MERRITT, Christopher K, AYE, Pyone P, ALEXA, Pavel, WARD, Richard L, LACKNER, Andrew A, BORDA, Juan, SAYLOR, Elizabeth, SCHWAMBERGER, Shelle R, COGSWELL, Frank, DIDIER, Elizabeth S, DIDIER, Peter J, PLAUCHE, Gail, BOHM, Rudolf P

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Chemokine Receptor Expression and Signaling in Macaque and Human Fetal Neurons and Astrocytes: Implications for the Neuropathogenesis of AIDS by Klein, Robyn S, Williams, Kenneth C, Alvarez-Hernandez, Xavier, Westmoreland, Susan, Force, Thomas, Lackner, Andrew A, Luster, Andrew D

“…Chemokines are believed to play a role in the neuropathogenesis of AIDS through their recruitment of neurotoxin-secreting, virally infected leukocytes into the…”
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Both Mucosal and Systemic Routes of Immunization with the Live, Attenuated NYVAC/Simian Immunodeficiency Virus SIVgpe Recombinant Vaccine Result in Gag-Specific CD8+ T-Cell Responses in Mucosal Tissues of Macaques by Stevceva, Liljana, Alvarez, Xavier, Lackner, Andrew A., Tryniszewska, Elzbieta, Kelsall, Brian, Nacsa, Janos, Tartaglia, Jim, Strober, Warren, Franchini, Genoveffa

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A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus by Desrosiers, R C, Sasseville, V G, Czajak, S C, Zhang, X, Mansfield, K G, Kaur, A, Johnson, R P, Lackner, A A, Jung, J U

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Quantitative neuropathologic correlates of changes in ratio of N-acetylaspartate to creatine in macaque brain by Lentz, Margaret R, Kim, John P, Westmoreland, Susan V, Greco, Jane B, Fuller, Robert A, Ratai, Eva M, He, Julian, Sehgal, Prabhat K, Halpern, Elkan F, Lackner, Andrew A, Masliah, Eliezer, González, R Gilberto

“…To elucidate the neuropathologic basis of transient changes in the ratio of N-acetylaspartate (NAA) to creatine (Cr) in the primate brain by using a simian…”
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Inhibition of intracellular transport of B cell antigen receptor complexes by Kaposi's sarcoma-associated herpesvirus K1 by Lee, B S, Alvarez, X, Ishido, S, Lackner, A A, Jung, J U

“…The B cell antigen receptor (BCR) is a large complex that consists of a disulfide-linked tetramer of two transmembrane heavy (mu) chains and two light (lambda…”
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