Search Results - "Lackey, K"

Tectonic Influences on Trench Slope Basin Development via Structural Restoration Along the Outer Nankai Accretionary Prism, Southwest Japan by J. K. Lackey, C. A. Regalla, G. F. Moore

“…Abstract Three‐dimensional (3‐D) seismic reflection data and sediment cores record ~2.87 million years of structural and depositional history of a trench slope…”
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Analysis of mutations in Neurospora crassa ERMES components reveals specific functions related to β-barrel protein assembly and maintenance of mitochondrial morphology by Wideman, Jeremy G, Lackey, Sebastian W K, Srayko, Martin A, Norton, Kacie A, Nargang, Frank E

“…The endoplasmic reticulum mitochondria encounter structure (ERMES) tethers the er to mitochondria and contains four structural components: Mmm1, Mdm12, Mdm10,…”
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The Neurospora crassa TOB complex: analysis of the topology and function of Tob38 and Tob37 by Lackey, Sebastian W K, Wideman, Jeremy G, Kennedy, Erin K, Go, Nancy E, Nargang, Frank E

“…The TOB or SAM complex is responsible for assembling several proteins into the mitochondrial outer membrane, including all β-barrel proteins. We have…”
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Oxindole-Based Inhibitors of Cyclin-Dependent Kinase 2 (CDK2):  Design, Synthesis, Enzymatic Activities, and X-ray Crystallographic Analysis by Bramson, H. Neal, Corona, John, Davis, Stephen T, Dickerson, Scott H, Edelstein, Mark, Frye, Stephen V, Gampe, Robert T, Harris, Phil A, Hassell, Anne, Holmes, William D, Hunter, Robert N, Lackey, Karen E, Lovejoy, Brett, Luzzio, Michael J, Montana, Val, Rocque, Warren J, Rusnak, David, Shewchuk, Lisa, Veal, James M, Walker, Duncan H, Kuyper, Lee F

“…Two closely related classes of oxindole-based compounds, 1H-indole-2,3-dione 3-phenylhydrazones and 3-(anilinomethylene)-1,3-dihydro-2H-indol-2-ones, were…”
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Current review of small molecule Ret kinase inhibitors by Zuercher, W J, Turunen, B J, Lackey, K E

“…Aberrant Ret kinase activity has been implicated in multiple carcinomas and disorders. Many strategies have been implemented to identify Ret kinase inhibitors…”
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Effects of Recent Instability on Cultivated Area Along the Euphrates River in Iraq by Gibson, Glen R., Taylor, Nicole L., Lamo, Nolan C., Lackey, Jason K.

“…We used MODIS NDVI data to determine whether there was a significant change in cultivated area along the Euphrates River in Iraq after the Iraq War compared to…”
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Assessing community needs for expanding environmental education programming by Hintz, Carly J., Lackey, Brenda K.

“…Based on increased demand for educational programming, leadership at Schmeeckle Reserve, a campus natural area in Stevens Point, WI explored the needs for…”
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Contextual Analysis of Interpretation Focused on Human-Black Bear Conflicts in Yosemite National Park by Lackey, Brenda K.

“…This study examined how Yosemite National Park addresses the continuing problem of human-bear interactions with its interpretive communication services. A…”
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A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells by WOOD, Edgar R, TRUESDALE, Anne T, ALLIGOOD, Krystal J, RUSNAK, David W, GILMER, Tona M, SHEWCHUK, Lisa, MCDONALD, Octerloney B, YUAN, Derek, HASSELL, Anne, DICKERSON, Scott H, ELLIS, Byron, PENNISI, Christopher, HORNE, Earnest, LACKEY, Karen

“…GW572016 (Lapatinib) is a tyrosine kinase inhibitor in clinical development for cancer that is a potent dual inhibitor of epidermal growth factor receptor…”
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Characterization of the insertase for β-barrel proteins of the outer mitochondrial membrane by Klein, Astrid, Israel, Lars, Lackey, Sebastian W K, Nargang, Frank E, Imhof, Axel, Baumeister, Wolfgang, Neupert, Walter, Thomas, Dennis R

“…The TOB-SAM complex is an essential component of the mitochondrial outer membrane that mediates the insertion of β-barrel precursor proteins into the membrane…”
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Evidence Supporting the 19 β-Strand Model for Tom40 from Cysteine Scanning and Protease Site Accessibility Studies by Lackey, Sebastian W.K., Taylor, Rebecca D., Go, Nancy E., Wong, Annie, Sherman, E.Laura, Nargang, Frank E.

“…Most proteins found in mitochondria are translated in the cytosol and enter the organelle via the TOM complex (translocase of the outer mitochondrial…”
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Roles of the Mdm10, Tom7, Mdm12, and Mmm1 proteins in the assembly of mitochondrial outer membrane proteins in Neurospora crassa by Wideman, Jeremy G, Go, Nancy E, Klein, Astrid, Redmond, Erin, Lackey, Sebastian W K, Tao, Tan, Kalbacher, Hubert, Rapaport, Doron, Neupert, Walter, Nargang, Frank E

“…The Mdm10, Mdm12, and Mmm1 proteins have been implicated in several mitochondrial functions including mitochondrial distribution and morphology, assembly of…”
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The Effects of the Novel, Reversible Epidermal Growth Factor Receptor/ErbB-2 Tyrosine Kinase Inhibitor, GW2016, on the Growth of Human Normal and Tumor-derived Cell Lines in Vitro and in Vivo by Rusnak, D W, Lackey, K, Affleck, K, Wood, E R, Alligood, K J, Rhodes, N, Keith, B R, Murray, D M, Knight, W B, Mullin, R J, Gilmer, T M

“…The epidermal growth factor receptor (EGFR) and ErbB-2 transmembrane tyrosine kinases are currently being targeted by various mechanisms in the treatment of…”
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A prodrug approach to the design of cRaf1 kinase inhibitors with improved cellular activity by Wood, E, Crosby, R M, Dickerson, S, Frye, S V, Griffin, R, Hunter, R, Jung, D K, McDonald, O B, McNutt, R, Mahony, W B, Peel, M R, Ray, J, Lackey, K

“…Earlier we reported potent cRaf1 kinase inhibitors with a key acidic phenol pharmacophore that had, at best, adequate cellular efficacy. To improve the…”
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SWCNT PEG-eggs: Single-walled carbon nanotubes in biocompatible shell-crosslinked micelles by Wang, Runtang, Cherukuri, Paul, Duque, Juan G., Leeuw, Tonya K., Lackey, Melinda K., Moran, Christine H., Moore, Valerie C., Conyers, Jodie L., Smalley, Richard E., Schmidt, Howard K., Weisman, R. Bruce, Engel, Paul S.

“…Pristine, individualized single-walled carbon nanotubes (SWCNTs) have been noncovalently captured within PEG-terminated block copolymer amphiphiles. Two…”
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Unusual eyelid tumors with sebaceous differentiation in the Muir-Torre syndrome. Rapid clinical regrowth and frank squamous transformation after biopsy by Jakobiec, F A, Zimmerman, L E, La Piana, F, Hornblass, A, Breffeilh, R A, Lackey, J K

“…An unusual eyelid tumor with sebaceous differentiation developed in two 70-year-old men and each had an earlier history of one or more colonic carcinomas--the…”
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The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: Potential therapy for cancer by RUSNAK, David W, AFFLECK, Karen, JOWETT, Amanda, STABLES, Jeremy, TOPLEY, Peter, WOOD, Edgar R, BRIGNOLA, Perry S, KADWELL, Sue H, REEP, Bryan R, MULLIN, Robert J, ALLIGOOD, Krystal J, KEITH, Barry R, COCKERILL, Stuart G, CROSBY, Renae M, MURRAY, Doris M, KNIGHT, W. Blaine, GILMER, Tona M, LACKEY, Karen, STUBBERFIELD, Colin, HARRIS, Robert, PAGE, Martin, SMITH, Kathryn J, GUNTRIP, Stephen B, CARTER, Malcolm C, SHAW, Robert J

“…The type I receptor tyrosine kinases constitute a family of transmembrane proteins involved in various aspects of cell growth and survival and have been…”
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The impact of child life specialists in an outpatient pediatric ophthalmology clinic by Lackey, Leeanne K., Donahue, Sean

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Correlations between scores on the Wechsler Intelligence Scale for Children-III and the General Purpose Abbreviated Battery of the Stanford-Binet IV by Carvajal, H H, Hayes, J E, Lackey, K L, Rathke, M L, Wiebe, D A, Weaver, K A

“…Estimations of some relationships among scores on the "General Purpose Abbreviated Battery" of the Stanford-Binet: Fourth Edition and the Wechsler Intelligence…”
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Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles by WOOD, Edgar R, KUYPER, Lee, PETROV, Kimberly G, HUNTER, Robert N, HARRIS, Philip A, LACKEY, Karen

“…The discovery, synthesis, potential binding mode, and in vitro kinase profile of…”
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