Search Results - "Lacinski, Ryan A."

Single-cell RNA-seq reveals intratumoral heterogeneity in osteosarcoma patients: A review by Thomas, Dylan D., Lacinski, Ryan A., Lindsey, Brock A.

“…Single-cell RNA-sequencing (scRNA-seq) was utilized to investigate the intratumoral heterogeneity of primary, recurrent, and metastatic osteosarcoma (OS)…”
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Synthesis, Characterization, and In Vivo Cytokinome Profile of IL-12-Loaded PLGA Nanospheres by Lacinski, Ryan A., Markel, Justin E., Noore, Jabeen, Pratt, Hillary G., Lindsey, Brock A.

“…We report the successful encapsulation and elution of recombinant murine IL-12 (rmIL-12) from poly(lactide-co-glycolic) acid (PLGA) nanospheres (IL-12-NS)…”
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Proteomic and transcriptomic analyses identify apo-transcobalamin-II as a biomarker of overall survival in osteosarcoma by Lacinski, Ryan A., Dziadowicz, Sebastian A., Roth, Clark A., Ma, Li, Melemai, Vincent K., Fitzpatrick, Brody, Chaharbakhshi, Edwin, Heim, Tanya, Lohse, Ines, Schoedel, Karen E., Hu, Gangqing, Llosa, Nicolas J., Weiss, Kurt R., Lindsey, Brock A.

“…Background The large-scale proteomic platform known as the SomaScan® assay is capable of simultaneously measuring thousands of proteins in patient specimens…”
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Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma by Lacinski, Ryan A, Dziadowicz, Sebastian A, Melemai, Vincent K, Fitzpatrick, Brody, Pisquiy, John J, Heim, Tanya, Lohse, Ines, Schoedel, Karen E, Llosa, Nicolas J, Weiss, Kurt R, Lindsey, Brock A

“…Patients diagnosed with advanced osteosarcoma, often in the form of lung metastases, have abysmal five-year overall survival rates. The complexity of the…”
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Nanosphere pharmacodynamics improves safety of immunostimulatory cytokine therapy by Lacinski, Ryan A., Dziadowicz, Sebastian A., Stewart, Amanda, Chaharbakhshi, Edwin, Akhter, Halima, Pisquiy, John J., Victory, Jack H., Hardham, Joshua B., Chew, Claude, Prorock, Alyson, Bao, Yongde, Sol-Church, Katia, Hobbs, Gerald R., Klein, Edwin, Nalesnik, Michael A., Hu, Gangqing, de Oliveira, Ana, Santiago, Stell P., Lindsey, Brock A.

“…Systemic administration of interleukin (IL)-12 induces potent anti-tumor immune responses in preclinical cancer models through the systemic activation of…”
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Spaceflight-associated pain by Nelson, Ariana M, Lacinski, Ryan A, Steller, Jonathan G

“…Consequences of the expanding commercial spaceflight industry include an increase in total number of spaceflight participants and an accompanying surge in the…”
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Optimizing the synthesis of interleukin‐12‐loaded PLGA nanospheres (rmIL‐12ns) via ultrasonication for treatment of metastatic osteosarcoma by Lacinski, Ryan A., Markel, Justin E., Pratt, Hillary G., Reinbeau, Ryan M., Stewart, Amanda, Santiago, Stell P., Lindsey, Brock A.

“…Clinical trials exploring bolus intravenous delivery of interleukin‐12 (IL‐12) for treatment of solid tumors ultimately failed due to lack of clinical response…”
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Nanocapsule Delivery of IL-12 by Markel, Justin E, Lacinski, Ryan A, Lindsey, Brock A

“…Interleukin(IL)-12 is a protein that activates T cells and macrophages to kill tumor cells. However, despite this cytokine showing strong antitumor activity in…”
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