Search Results - "Lachman, M"

CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells by Wang, Ping, Mokhtari, Ryan, Pedrosa, Erika, Kirschenbaum, Michael, Bayrak, Can, Zheng, Deyou, Lachman, Herbert M

“…(chromodomain helicase DNA-binding protein 8), which codes for a member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the most…”
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Characterization of human pseudogene-derived non-coding RNAs for functional potential by Guo, Xingyi, Lin, Mingyan, Rockowitz, Shira, Lachman, Herbert M, Zheng, Deyou

“…Thousands of pseudogenes exist in the human genome and many are transcribed, but their functional potential remains elusive and understudied. To explore these…”
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Feed efficiency phenotypes in lambs involve changes in ruminal, colonic, and small-intestine-located microbiota by Perea, K, Perz, K, Olivo, S K, Williams, A, Lachman, M, Ishaq, S L, Thomson, J, Yeoman, C J

“…Several studies have revealed differences in rumen-located microbes between greatly efficient and inefficient animals; however, how the microbiota vary in the…”
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Feed efficiency phenotypes in lambs involve changes in ruminal, colonic, and small-intestine-located microbiota by Perea, K, Perz, K, Olivo, S K, Williams, A, Lachman, M, Ishaq, S L, Thomson, J, Yeoman, C J

“…Several studies have revealed differences in rumen-located microbes between greatly efficient and inefficient animals; however, how the microbiota vary in the…”
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Transcriptomics analysis of iPSC-derived neurons and modeling of neuropsychiatric disorders by Lin, Mingyan, Lachman, Herbert M., Zheng, Deyou

“…Induced pluripotent stem cell (iPSC)-derived neurons and neural progenitors are great resources for studying neural development and differentiation and their…”
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Heat shock alters the expression of schizophrenia and autism candidate genes in an induced pluripotent stem cell model of the human telencephalon by Lin, Mingyan, Zhao, Dejian, Hrabovsky, Anastasia, Pedrosa, Erika, Zheng, Deyou, Lachman, Herbert M

“…Schizophrenia (SZ) and autism spectrum disorders (ASD) are highly heritable neuropsychiatric disorders, although environmental factors, such as maternal immune…”
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MicroRNA Profiling of Neurons Generated Using Induced Pluripotent Stem Cells Derived from Patients with Schizophrenia and Schizoaffective Disorder, and 22q11.2 Del by Zhao, Dejian, Lin, Mingyan, Chen, Jian, Pedrosa, Erika, Hrabovsky, Anastasia, Fourcade, H Matthew, Zheng, Deyou, Lachman, Herbert M

“…We are using induced pluripotent stem cell (iPSC) technology to study neuropsychiatric disorders associated with 22q11.2 microdeletions (del), the most common…”
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Integrating intimate partner violence prevention content into a digital parenting chatbot intervention during COVID-19: Intervention development and remote data collection by Schafer, Moa, Lachman, Jamie M, Gardner, Frances, Zinser, Paula, Calderon, Francisco, Han, Qing, Facciola, Chiara, Clements, Lily

“…Background Intimate partner violence (IPV) is a serious public health issue which experienced a sharp incline during the onset of COVID-19. Increases in other…”
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The impact of the parenting for respectability programme on violent parenting and intimate partner relationships in Uganda: A pre-post study by Siu, Godfrey, Nsubuga, Rebecca N, Lachman, Jamie M, Namutebi, Carol, Sekiwunga, Richard, Zalwango, Flavia, Riddell, Julie, Wight, Daniel

“…There is a growing need for interventions that reduce both violence against children and intimate partner violence in low- and middle-income countries…”
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CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment by Wang, Ping, Lin, Mingyan, Pedrosa, Erika, Hrabovsky, Anastasia, Zhang, Zheng, Guo, Wenjun, Lachman, Herbert M, Zheng, Deyou

“…Disruptive mutation in the CHD8 gene is one of the top genetic risk factors in autism spectrum disorders (ASDs). Previous analyses of genome-wide CHD8…”
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The catechol-O-methyltransferase polymorphism: Relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes by BILDER, Robert M, VOLAVKA, Jan, LACHMAN, Herbert M, GRACES, Anthony A

“…Diverse phenotypic associations with the catechol-O-methyltransferase (COMT) Val158Met polymorphism have been reported. We suggest that some of the complex…”
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Characterization of cell-cell communication in autistic brains with single-cell transcriptomes by Astorkia, Maider, Lachman, Herbert M, Zheng, Deyou

“…Autism spectrum disorder is a neurodevelopmental disorder, affecting 1-2% of children. Studies have revealed genetic and cellular abnormalities in the brains…”
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Reduced CYFIP1 in Human Neural Progenitors Results in Dysregulation of Schizophrenia and Epilepsy Gene Networks by Nebel, Rebecca A, Zhao, Dejian, Pedrosa, Erika, Kirschen, Jill, Lachman, Herbert M, Zheng, Deyou, Abrahams, Brett S

“…Deletions encompassing the BP1-2 region at 15q11.2 increase schizophrenia and epilepsy risk, but only some carriers have either disorder. To investigate the…”
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Innovate! Accelerate! Evaluate! Harnessing the RE-AIM framework to examine the global dissemination of parenting resources during COVID-19 to more than 210 million people by Lachman, Jamie M, Nurova, Nisso, Chetty, Angelique Nicole, Fang, Zuyi, Swartz, Alison, Sherr, Lorraine, Mebrahtu, Helen, Mwaba, Kasonde, Green, Ohad, Awah, Isang, Chen, Yuanling, Vallance, Inge, Cluver, Lucie

“…Parents were at the forefront of responding to the needs of children during the COVID-19 pandemic. This study used the RE-AIM framework to examine the Reach,…”
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Identification of ultra-rare genetic variants in pediatric acute onset neuropsychiatric syndrome (PANS) by exome and whole genome sequencing by Trifiletti, Rosario, Lachman, Herbert M., Manusama, Olivia, Zheng, Deyou, Spalice, Alberto, Chiurazzi, Pietro, Schornagel, Allan, Serban, Andreea M., van Wijck, Rogier, Cunningham, Janet L., Swagemakers, Sigrid, van der Spek, Peter J.

“…Abrupt onset of severe neuropsychiatric symptoms including obsessive–compulsive disorder, tics, anxiety, mood swings, irritability, and restricted eating is…”
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Feasibility pilot of an adapted parenting program embedded within the Thai public health system by McCoy, Amalee, Lachman, Jamie M, Ward, Catherine L, Tapanya, Sombat, Poomchaichote, Tassawan, Kelly, Jane, Mukaka, Mavuto, Cheah, Phaik Yeong, Gardner, Frances

“…This feasibility pilot of the Parenting for Lifelong Health for Young Children program in Thailand aimed to: 1) explore the feasibility of study evaluation…”
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Optimising engagement in a digital parenting intervention to prevent violence against adolescents in Tanzania: protocol for a cluster randomised factorial trial by Janowski, Roselinde, Green, Ohad, Shenderovich, Yulia, Stern, David, Clements, Lily, Wamoyi, Joyce, Wambura, Mwita, Lachman, Jamie M, Melendez-Torres, G J, Gardner, Frances, Baerecke, Lauren, Te Winkel, Esmee, Booij, Anna, Setton, Orli, Tsoanyane, Sibongile, Mjwara, Sussie, Christine, Laetitia, Ornellas, Abigail, Chetty, Nicole, Klapwijk, Jonathan, Awah, Isang, Manjengenja, Nyasha, Sokoine, Kudely, Majikata, Sabrina, Cluver, Lucie D

“…Violence against adolescents is a universal reality, with severe individual and societal costs. There is a critical need for scalable and effective violence…”
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Mediation pathways for reduced substance use among parents in South Africa: a randomized controlled trial by Massarwi, Adeem Ahmad, Cluver, Lucie, Meinck, Franziska, Doubt, Jenny, Lachman, Jamie M, Shenderovich, Yulia, Green, Ohad

“…Substance use is a major public health concern worldwide. Alcohol and drug use have increased during recent decades in many low- and middle-income countries,…”
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KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons by Yheskel, Matanel, Hatch, Hayden A M, Pedrosa, Erika, Terry, Bethany K, Siebels, Aubrey A, Zheng, Xiang Yu, Blok, Laura E R, Fencková, Michaela, Sidoli, Simone, Schenck, Annette, Zheng, Deyou, Lachman, Herbert M, Secombe, Julie

“…Genes encoding the KDM5 family of transcriptional regulators are disrupted in individuals with intellectual disability (ID). To understand the link between…”
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The Association Between Facilitator Competent Adherence and Outcomes in Parenting Programs: a Systematic Review and SWiM Analysis by Martin, M., Steele, B., Spreckelsen, T. F., Lachman, J. M., Gardner, F., Shenderovich, Y.

“…There is increasing interest about the fidelity with which interventions are implemented because it is theorized that better implementation fidelity by…”
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