Pharmacodynamics and clinical efficacy of fentanyl iontophoretic transdermal system for post-operative pain in hospitalized patients

The fentanyl iontophoretic transdermal system (ITS) is a patient-controlled transdermal system allowing needle-free administration of on-demand doses of Fentanyl of 40 µg over a 10-min period up to 80 doses or over a 24-h period. It is indicated in opioid naïve patients for the treatment of acute po...

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Bibliographic Details
Published in:	Expert opinion on drug metabolism & toxicology Vol. 11; no. 12; p. 1925
Main Authors:	Skledar, Susan J, Lachell, Carsten M, Chelly, Jacques E
Format:	Journal Article
Language:	English
Published:	England 02-12-2015
Subjects:	Administration, Cutaneous Analgesia, Patient-Controlled - methods Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Fentanyl - administration & dosage Fentanyl - adverse effects Humans Iontophoresis Morphine - administration & dosage Morphine - adverse effects Pain, Postoperative - drug therapy Patient Satisfaction Randomized Controlled Trials as Topic patient-controlled transdermal fentanyl opioid postoperative analgesia pain management iontophoretic system
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Summary:	The fentanyl iontophoretic transdermal system (ITS) is a patient-controlled transdermal system allowing needle-free administration of on-demand doses of Fentanyl of 40 µg over a 10-min period up to 80 doses or over a 24-h period. It is indicated in opioid naïve patients for the treatment of acute postoperative pain in the hospitalized patients for up to 72 h. It has been demonstrated to be effective and safe in randomized trials and to provide comparable analgesia versus morphine intravenous (i.v.) patient-controlled analgesia (PCA) with adverse events similar between groups. Fentanyl ITS has shown high patient satisfaction rates, and was described by patients and investigators as easy and convenient to use. These properties make this technology interesting when considering perioperative pain management. In the present health care environment additional data are required to establish the cost-benefit ratio of this technology in optimizing patient's recovery from surgery.
ISSN:	1744-7607
DOI:	10.1517/17425255.2015.1112788