Search Results - "Lacey, Brian"

Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function by Wang, Yun, Zhang, Kelvin, Georgiev, Peter, Wells, Steven, Xu, Haiyan, Lacey, Brian M, Xu, Zangwei, Laskey, Jason, Mcleod, Robbie, Methot, Joey L, Bittinger, Mark, Pasternak, Alexander, Ranganath, Sheila

“…Hematopoietic progenitor kinase 1 (HPK1), a hematopoietic cell-specific Ste20-related serine/threonine kinase, is a negative regulator of signal transduction…”
Get full text

An orally available non-nucleotide STING agonist with antitumor activity by Pan, Bo-Sheng, Perera, Samanthi A, Piesvaux, Jennifer A, Presland, Jeremy P, Schroeder, Gottfried K, Cumming, Jared N, Trotter, B Wesley, Altman, Michael D, Buevich, Alexei V, Cash, Brandon, Cemerski, Saso, Chang, Wonsuk, Chen, Yiping, Dandliker, Peter J, Feng, Guo, Haidle, Andrew, Henderson, Timothy, Jewell, James, Kariv, Ilona, Knemeyer, Ian, Kopinja, Johnny, Lacey, Brian M, Laskey, Jason, Lesburg, Charles A, Liang, Rui, Long, Brian J, Lu, Min, Ma, Yanhong, Minnihan, Ellen C, O'Donnell, Greg, Otte, Ryan, Price, Laura, Rakhilina, Larissa, Sauvagnat, Berengere, Sharma, Sharad, Tyagarajan, Sriram, Woo, Hyun, Wyss, Daniel F, Xu, Serena, Bennett, David Jonathan, Addona, George H

“…Pharmacological activation of the STING (stimulator of interferon genes)-controlled innate immune pathway is a promising therapeutic strategy for cancer. Here…”
Get full text

Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING by Siu, Tony, Altman, Michael D, Baltus, Gretchen A, Childers, Matthew, Ellis, J. Michael, Gunaydin, Hakan, Hatch, Harold, Ho, Thu, Jewell, James, Lacey, Brian M, Lesburg, Charles A, Pan, Bo-Sheng, Sauvagnat, Berengere, Schroeder, Gottfried K, Xu, Serena

“…Drugging large protein pockets is a challenge due to the need for higher molecular weight ligands, which generally possess undesirable physicochemical…”
Get full text

Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa by Han, Seungil, Zaniewski, Richard P., Marr, Eric S., Lacey, Brian M., Tomaras, Andrew P., Evdokimov, Artem, Miller, J. Richard, Shanmugasundaram, Veerabahu, Corey, E. J.

“…Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen that causes nosocomial infections for which there are limited treatment options…”
Get full text

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer by Chang, Wonsuk, Altman, Michael D, Lesburg, Charles A, Perera, Samanthi A, Piesvaux, Jennifer A, Schroeder, Gottfried K, Wyss, Daniel F, Cemerski, Saso, Chen, Yiping, DiNunzio, Edward, Haidle, Andrew M, Ho, Thu, Kariv, Ilona, Knemeyer, Ian, Kopinja, Johnny E, Lacey, Brian M, Laskey, Jason, Lim, Jongwon, Long, Brian J, Ma, Yanhong, Maddess, Matthew L, Pan, Bo-Sheng, Presland, Jeremy P, Spooner, Edward, Steinhuebel, Dietrich, Truong, Quang, Zhang, Zhibo, Fu, Jianmin, Addona, George H, Northrup, Alan B, Parmee, Emma, Tata, James R, Bennett, David Jonathan, Cumming, Jared N, Siu, Tony, Trotter, B. Wesley

“…Stereochemically and structurally complex cyclic dinucleotide-based stimulator of interferon genes (STING) agonists were designed and synthesized to access a…”
Get full text

Multiple Synthetic Routes to the Mini-Protein Omomyc and Coiled-Coil Domain Truncations by Brown, Zachary Z, Mapelli, Claudio, Farasat, Iman, Shoultz, Alycia V, Johnson, Scott A, Orvieto, Federica, Santoprete, Alessia, Bianchi, Elisabetta, McCracken, Amy Bittner, Chen, Kuanchang, Zhu, Xiaohong, Demma, Mark J, Lacey, Brian M, Canada, Keith A, Garbaccio, Robert M, O’Neil, Jennifer, Walji, Abbas

“…The Myc transcription factor represents an “undruggable” target of high biological interest due to its central role in various cancers. An abbreviated form of…”
Get full text

The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer by Quiroz, Ryan V, Reutershan, Michael H, Schneider, Sebastian E, Sloman, David, Lacey, Brian M, Swalm, Brooke M, Yeung, Charles S, Gibeau, Craig, Spellman, Daniel S, Rankic, Danica A, Chen, Dapeng, Witter, David, Linn, Doug, Munsell, Erik, Feng, Guo, Xu, Haiyan, Hughes, Jonathan M. E, Lim, Jongwon, Saurí, Josep, Geddes, Kristin, Wan, Murray, Mansueto, My Sam, Follmer, Nicole E, Fier, Patrick S, Siliphaivanh, Phieng, Daublain, Pierre, Palte, Rachel L, Hayes, Robert P, Lee, Sandra, Kawamura, Shuhei, Silverman, Steven, Sanyal, Sulagna, Henderson, Timothy J, Ye, Yingchun, Gao, Yuanwei, Nicholson, Benjamin, Machacek, Michelle R

“…Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyzes the post-translational symmetric dimethylation of protein…”
Get full text

Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5) by Palte, Rachel L, Schneider, Sebastian E, Altman, Michael D, Hayes, Robert P, Kawamura, Shuhei, Lacey, Brian M, Mansueto, My Sam, Reutershan, Michael, Siliphaivanh, Phieng, Sondey, Christopher, Xu, Haiyan, Xu, Zangwei, Ye, Yingchun, Machacek, Michelle R

“…Protein arginine methyltransferase 5 (PRMT5) belongs to a family of enzymes that regulate the posttranslational modification of histones and other proteins via…”
Get full text

Clinically Relevant Gram-Negative Resistance Mechanisms Have No Effect on the Efficacy of MC-1, a Novel Siderophore-Conjugated Monocarbam by McPherson, Craig J, Aschenbrenner, Lisa M, Lacey, Brian M, Fahnoe, Kelly C, Lemmon, Margaret M, Finegan, Steven M, Tadakamalla, Baswanth, O'Donnell, John P, Mueller, John P, Tomaras, Andrew P

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Identification of Potent Reverse Indazole Inhibitors for HPK1 by Yu, Elsie C, Methot, Joey L, Fradera, Xavier, Lesburg, Charles A, Lacey, Brian M, Siliphaivanh, Phieng, Liu, Ping, Smith, Dustin M, Xu, Zangwei, Piesvaux, Jennifer A, Kawamura, Shuhei, Xu, Haiyan, Miller, J. Richard, Bittinger, Mark, Pasternak, Alexander

“…Hematopoietic progenitor kinase (HPK1), a negative regulator of TCR-mediated T-cell activation, has been recognized as a novel antitumor immunotherapy target…”
Get full text

Seasonality of Nosema ceranae Infections and Their Relationship with Honey Bee Populations, Food Stores, and Survivorship in a North American Region by Emsen, Berna, De la Mora, Alvaro, Lacey, Brian, Eccles, Les, Kelly, Paul G., Medina-Flores, Carlos A., Petukhova, Tatiana, Morfin, Nuria, Guzman-Novoa, Ernesto

“…Nosema ceranae is an emerging pathogen of the western honey bee (Apis mellifera L.), and thus its seasonality and impact on bee colonies is not sufficiently…”
Get full text

Distinctive Attributes of β-Lactam Target Proteins in Acinetobacter baumannii Relevant to Development of New Antibiotics by Han, Seungil, Caspers, Nicole, Zaniewski, Richard P, Lacey, Brian M, Tomaras, Andrew P, Feng, Xidong, Geoghegan, Kieran F, Shanmugasundaram, Veerabahu

“…Multi-drug-resistant forms of the Gram-negative pathogen Acinetobacter baumannii are an emerging threat to human health and further complicate the general…”
Get full text

Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds by Vara, Brandon A, Levi, Samuel M, Achab, Abdelghani, Candito, David A, Fradera, Xavier, Lesburg, Charles A, Kawamura, Shuhei, Lacey, Brian M, Lim, Jongwon, Methot, Joey L, Xu, Zangwei, Xu, Haiyan, Smith, Dustin M, Piesvaux, Jennifer A, Miller, J. Richard, Bittinger, Mark, Ranganath, Sheila H, Bennett, David J, DiMauro, Erin F, Pasternak, Alexander

“…Hematopoietic progenitor kinase 1 (HPK1), a serine/threonine kinase, is a negative immune regulator of T cell receptor (TCR) and B cell signaling that is…”
Get full text

Early Insights into the Interactions of Different β-Lactam Antibiotics and β-Lactamase Inhibitors against Soluble Forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3 by Papp-Wallace, Krisztina M, Senkfor, Baui, Gatta, Julian, Chai, Weirui, Taracila, Magdalena A, Shanmugasundaram, Veerabahu, Han, Seungil, Zaniewski, Richard P, Lacey, Brian M, Tomaras, Andrew P, Skalweit, Marion J, Harris, Michael E, Rice, Louis B, Buynak, John D, Bonomo, Robert A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors by Lacey, Brian M, Xu, Zangwei, Chai, Xiaomei, Laskey, Jason, Fradera, Xavier, Mittal, Payal, Mishra, Sasmita, Piesvaux, Jennifer, Saradjian, Peter, Shaffer, Lynsey, Vassileva, Galya, Gerdt, Catherine, Wang, Yun, Ferguson, Heidi, Smith, Dustin M, Ballard, Jeanine, Wells, Steven, Jain, Rishabh, Mueller, Uwe, Addona, George, Kariv, Ilona, Methot, Joey L, Bittinger, Mark, Ranganath, Sheila, Mcleod, Robbie, Pasternak, Alexander, Miller, J Richard, Xu, Haiyan

“…Hematopoietic progenitor kinase 1 (HPK1), also referred to as mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1), is a serine/threonine kinase…”
Get more information

Selenium in Thioredoxin Reductase: A Mechanistic Perspective by Lacey, Brian M, Eckenroth, Brian E, Flemer, Stevenson, Hondal, Robert J

“…Most high M r thioredoxin reductases (TRs) have the unusual feature of utilizing a vicinal disulfide bond (Cys1−Cys2) which forms an eight-membered ring during…”
Get full text

Characterization of mitochondrial thioredoxin reductase from C. elegans by Lacey, Brian M., Hondal, Robert J.

“…Thioredoxin reductase catalyzes the NADPH-dependent reduction of the catalytic disulfide bond of thioredoxin. In mammals and other higher eukaryotes,…”
Get full text

Investigation of the C-Terminal Redox Center of High-M r Thioredoxin Reductase by Protein Engineering and Semisynthesis by Eckenroth, Brian E, Lacey, Brian M, Lothrop, Adam P, Harris, Katharine M, Hondal, Robert J

“…High-molecular weight thioredoxin reductases (TRs) catalyze the reduction of the redox-active disulfide bond of thioredoxin, but an important difference in the…”
Get full text

Investigation of the C-Terminal Redox Center of High-Mr Thioredoxin Reductase by Protein Engineering and Semisynthesis by ECKENROTH, Brian E., LACEY, Brian M., LOTHROP, Adam P., HARRIS, Katharine M., HONDAL, Robert J.

“…High-molecular weight thioredoxin reductases (TRs) catalyze the reduction of the redox-active disulfide bond of thioredoxin, but an important difference in the…”
Get full text

Synthesis of peptide substrates for mammalian thioredoxin reductase by Flemer Jr, Stevenson, Lacey, Brian M., Hondal, Robert J.

“…Mammalian thioredoxin reductase (TR) catalyzes the reduction of the redox‐active disulfide bond of thioredoxin (Trx) and is similar in structure and mechanism…”
Get full text