Search Results - "Lacerda, Marcus V"

Malaria in Brazil, Colombia, Peru and Venezuela: current challenges in malaria control and elimination by Recht, Judith, Siqueira, André M, Monteiro, Wuelton M, Herrera, Sonia M, Herrera, Sócrates, Lacerda, Marcus V G

“…In spite of significant progress towards malaria control and elimination achieved in South America in the 2000s, this mosquito-transmitted tropical disease…”
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The role of the spleen in malaria by del Portillo, Hernando A., Ferrer, Mireia, Brugat, Thibaut, Martin‐Jaular, Lorena, Langhorne, Jean, Lacerda, Marcus V. G.

“…Summary The spleen is a complex organ that is perfectly adapted to selectively filtering and destroying senescent red blood cells (RBCs), infectious…”
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Keras R-CNN: library for cell detection in biological images using deep neural networks by Hung, Jane, Goodman, Allen, Ravel, Deepali, Lopes, Stefanie C P, Rangel, Gabriel W, Nery, Odailton A, Malleret, Benoit, Nosten, Francois, Lacerda, Marcus V G, Ferreira, Marcelo U, Rénia, Laurent, Duraisingh, Manoj T, Costa, Fabio T M, Marti, Matthias, Carpenter, Anne E

“…A common yet still manual task in basic biology research, high-throughput drug screening and digital pathology is identifying the number, location, and type of…”
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Pathological Methods Applied to the Investigation of Causes of Death in Developing Countries: Minimally Invasive Autopsy Approach by Castillo, Paola, Ussene, Esperança, Ismail, Mamudo R, Jordao, Dercio, Lovane, Lucilia, Carrilho, Carla, Lorenzoni, Cesaltina, Lacerda, Marcus V, Palhares, Antonio, Rodríguez-Carunchio, Leonardo, Martínez, Miguel J, Vila, Jordi, Bassat, Quique, Menéndez, Clara, Ordi, Jaume

“…Complete diagnostic autopsies (CDA) remain the gold standard in the determination of cause of death (CoD). However, performing CDAs in developing countries is…”
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Tafenoquine following G6PD screening versus primaquine for the treatment of vivax malaria in Brazil: A cost-effectiveness analysis using a transmission model by Price, David J, Nekkab, Narimane, Monteiro, Wuelton M, Villela, Daniel A M, Simpson, Julie A, Lacerda, Marcus V G, White, Michael T, Devine, Angela

“…Malaria transmission modelling has demonstrated the potential impact of semiquantitative glucose-6-phosphate dehydrogenase (G6PD) testing and treatment with…”
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Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b dose-selection study by Llanos-Cuentas, Alejandro, Prof, Lacerda, Marcus V, Prof, Rueangweerayut, Ronnatrai, MD, Krudsood, Srivicha, Prof, Gupta, Sandeep K, MD, Kochar, Sanjay K, MD, Arthur, Preetam, MD, Chuenchom, Nuttagarn, MD, Möhrle, Jörg J, PhD, Duparc, Stephan, MD, Ugwuegbulam, Cletus, PhD, Kleim, Jörg-Peter, PhD, Carter, Nick, MSc, Green, Justin A, MD, Kellam, Lynda, MSc

“…Summary Background Clinical effectiveness of previous regimens to treat Plasmodium vivax infection have been hampered by compliance. We aimed to assess the…”
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Malaria in Brazil: an overview by Oliveira-Ferreira, Joseli, Lacerda, Marcus V G, Brasil, Patrícia, Ladislau, José L B, Tauil, Pedro L, Daniel-Ribeiro, Cláudio Tadeu

“…Malaria is still a major public health problem in Brazil, with approximately 306,000 registered cases in 2009, but it is estimated that in the early 1940s,…”
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When fever is not malaria in Latin America: a systematic review by Moreira, José, Barros, Janaina, Lapouble, Oscar, Lacerda, Marcus V G, Felger, Ingrid, Brasil, Patricia, Dittrich, Sabine, Siqueira, Andre M

“…In malaria-endemic countries, febrile episodes caused by diseases other than malaria are a growing concern. However, limited knowledge of the prevalent…”
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The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis by Watson, James A, Commons, Robert J, Tarning, Joel, Simpson, Julie A, Llanos Cuentas, Alejandro, Lacerda, Marcus V G, Green, Justin A, Koh, Gavin C K W, Chu, Cindy S, Nosten, François H, Price, Richard N, Day, Nicholas P J, White, Nicholas J

“…Tafenoquine is a newly licensed antimalarial drug for the radical cure of malaria. The mechanism of action and optimal dosing are uncertain. We pooled…”
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Usability of a point-of-care diagnostic to identify glucose-6-phosphate dehydrogenase deficiency: a multi-country assessment of test label comprehension and results interpretation by Gerth-Guyette, Emily, Adissu, Wondimagegn, Brito, Marcelo, Garbin, Eduardo, Macedo, Marcela, Sharma, Abhijit, Das, Santasabuj, Lacerda, Marcus V. G, Pereira, Dhélio, Talukdar, Arunansu, Yilma, Daniel, Pal, Sampa, Zobrist, Stephanie, Domingo, Gonzalo J

“…Abstract Background Point-of-care glucose-6-phosphate dehydrogenase (G6PD) testing has the potential to make the use of radical treatment for vivax malaria…”
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CYP2D6 activity and the risk of recurrence of Plasmodium vivax malaria in the Brazilian Amazon: a prospective cohort study by Brasil, Larissa W, Rodrigues-Soares, Fernanda, Santoro, Ana B, Almeida, Anne C G, Kühn, Andrea, Ramasawmy, Rajendranath, Lacerda, Marcus V G, Monteiro, Wuelton M, Suarez-Kurtz, Guilherme

“…CYP2D6 pathway mediates the activation of primaquine into active metabolite(s) in hepatocytes. CYP2D6 is highly polymorphic, encoding CYP2D6 isoforms with…”
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A suitable RNA preparation methodology for whole transcriptome shotgun sequencing harvested from Plasmodium vivax-infected patients by Bourgard, Catarina, Lopes, Stefanie C. P., Lacerda, Marcus V. G., Albrecht, Letusa, Costa, Fabio T. M.

“…Plasmodium vivax is a world-threatening human malaria parasite, whose biology remains elusive. The unavailability of in vitro culture, and the difficulties in…”
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Perceptions about malaria among Brazilian gold miners in an Amazonian border area: perspectives for malaria elimination strategies by Murta, Felipe L. G, Marques, Leonardo L. G, Santos, Alicia P. C, Batista, Talita S. B, Mendes, Maxwell O, Silva, Elair D, Neto, Alexandre V. S, Fabiano, Marcio, Rodovalho, Sheila R, Monteiro, Wuelton M, Lacerda, Marcus V. G

“…Abstract Background Mining in the Amazon exposes gold miners to various diseases, including malaria, whose control is still a major challenge. The environment…”
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Author Correction: Impact of Plasmodium vivax malaria on executive and cognitive functions in elderlies in the Brazilian Amazon by Pessoa, Rockson C., Oliveira-Pessoa, Gabriela F., Souza, Brenda K. A., Sampaio, Vanderson S., Pinto, André Luiz C. B., Barboza, Larissa L., Mouta, Gabriel S., Silva, Emanuelle Lira, Melo, Gisely C., Monteiro, Wuelton M., Silva-Filho, José H., Lacerda, Marcus V. G., Baía-da-Silva, Djane Clarys

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Real-life quantitative G6PD screening in Plasmodium vivax patients in the Brazilian Amazon: A cost-effectiveness analysis by Brito-Sousa, Jose Diego, Peixoto, Henry M, Devine, Angela, Silva-Neto, Alexandre V, Balieiro, Patricia C S, Sampaio, Vanderson S, Vitor-Silva, Sheila, Mendes, Maxwell O, Souza, Brenda K A, Lacerda, Marcus V G, Monteiro, Wuelton M

“…As quantitative glucose 6-phosphate dehydrogenase deficiency (G6PDd) screening tools are evaluated in operational studies, questions remain as to whether they…”
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Response to comment on 'The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis' by Watson, James A, Commons, Robert J, Tarning, Joel, Simpson, Julie A, Llanos Cuentas, Alejandro, Lacerda, Marcus V G, Green, Justin A, Koh, Gavin C K W, Chu, Cindy S, Nosten, François H, Price, Richard N, Day, Nicholas P J, White, Nicholas J

“…In our recent paper on the clinical pharmacology of tafenoquine (Watson et al., 2022), we used all available individual patient pharmacometric data from the…”
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Poor efficacy of preemptive amoxicillin clavulanate for preventing secondary infection from Bothrops snakebites in the Brazilian Amazon: A randomized controlled clinical trial by Sachett, Jacqueline A G, da Silva, Iran Mendonça, Alves, Eliane Campos, Oliveira, Sâmella S, Sampaio, Vanderson S, do Vale, Fábio Francesconi, Romero, Gustavo Adolfo Sierra, Dos Santos, Marcelo Cordeiro, Marques, Hedylamar Oliveira, Colombini, Mônica, da Silva, Ana Maria Moura, Wen, Fan Hui, Lacerda, Marcus V G, Monteiro, Wuelton M, Ferreira, Luiz C L

“…Secondary bacterial infections from snakebites contribute to the high complication rates that can lead to permanent function loss and disabilities. Although…”
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Severe Plasmodium vivax malaria, Brazilian Amazon by Alexandre, Márcia A, Ferreira, Cynthia O, Siqueira, André M, Magalhães, Belisa L, Mourão, Maria Paula G, Lacerda, Marcus V, Alecrim, Maria das Gracas C

“…We describe a case series of 17 patients hospitalized in Manaus (western Brazilian Amazon) with PCR-confirmed Plasmodium vivax infection who were treated with…”
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Expression levels of pvcrt-o and pvmdr-1 are associated with chloroquine resistance and severe Plasmodium vivax malaria in patients of the Brazilian Amazon by Melo, Gisely C, Monteiro, Wuelton M, Siqueira, André M, Silva, Siuhelem R, Magalhães, Belisa M L, Alencar, Aline C C, Kuehn, Andrea, del Portillo, Hernando A, Fernandez-Becerra, Carmen, Lacerda, Marcus V G

“…Molecular markers associated with the increase of chloroquine resistance and disease severity in Plasmodium vivax are needed. The objective of this study was…”
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Dissecting disease tolerance in Plasmodium vivax malaria using the systemic degree of inflammatory perturbation by Vinhaes, Caian L, Carmo, Thomas A, Queiroz, Artur T L, Fukutani, Kiyoshi F, Araújo-Pereira, Mariana, Arriaga, María B, Lacerda, Marcus V G, Barral-Netto, Manoel, Andrade, Bruno B

“…Homeostatic perturbation caused by infection fosters two major defense strategies, resistance and tolerance, which promote the host's survival. Resistance…”
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