Search Results - "Lacek, Andrew T"

Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death by Kohlhapp, Frederick J., Huelsmann, Erica J., Lacek, Andrew T., Schenkel, Jason M., Lusciks, Jevgenijs, Broucek, Joseph R., Goldufsky, Josef W., Hughes, Tasha, Zayas, Janet P., Dolubizno, Hubert, Sowell, Ryan T., Kühner, Regina, Burd, Sarah, Kubasiak, John C., Nabatiyan, Arman, Marshall, Sh’Rae, Bommareddy, Praveen K., Li, Shengguo, Newman, Jenna H., Monken, Claude E., Shafikhani, Sasha H., Marzo, Amanda L., Guevara-Patino, Jose A., Lasfar, Ahmed, Thomas, Paul G., Lattime, Edmund C., Kaufman, Howard L., Zloza, Andrew

“…In light of increased cancer prevalence and cancer-specific deaths in patients with infections, we investigated whether infections alter anti-tumor immune…”
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Antigenic peptide nanofibers elicit adjuvant-free CD8+ T cell responses by Chesson, Charles B, Huelsmann, Erica J, Lacek, Andrew T, Kohlhapp, Frederick J, Webb, Matthew F, Nabatiyan, Arman, Zloza, Andrew, Rudra, Jai S

“…Highlights • Self-assembling peptide nanofibers elicit adjuvant-free CD8+ T cell responses. • Peptide nanofibers elicit augmented antigen-specific recall…”
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Mutant HSP70 reverses autoimmune depigmentation in vitiligo by Mosenson, Jeffrey A, Zloza, Andrew, Nieland, John D, Garrett-Mayer, Elizabeth, Eby, Jonathan M, Huelsmann, Erica J, Kumar, Previn, Denman, Cecele J, Lacek, Andrew T, Kohlhapp, Frederick J, Alamiri, Ahmad, Hughes, Tasha, Bines, Steven D, Kaufman, Howard L, Overbeck, Andreas, Mehrotra, Shikhar, Hernandez, Claudia, Nishimura, Michael I, Guevara-Patino, Jose A, Le Poole, I Caroline

“…Vitiligo is an autoimmune disease characterized by destruction of melanocytes, leaving 0.5% of the population with progressive depigmentation. Current…”
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NKG2D signaling on CD8+ T cells represses T-bet and rescues CD4-unhelped CD8+ T cell memory recall but not effector responses by Zloza, Andrew, Kohlhapp, Frederick J, Lyons, Gretchen E, Schenkel, Jason M, Moore, Tamson V, Lacek, Andrew T, O'Sullivan, Jeremy A, Varanasi, Vineeth, Williams, Jesse W, Jagoda, Michael C, Bellavance, Emily C, Marzo, Amanda L, Thomas, Paul G, Zafirova, Biljana, Polić, Bojan, Al-Harthi, Lena, Sperling, Anne I, Guevara-Patiño, José A

“…CD8 + T cells primed in the absence of CD4 + T cell help fail to develop a robust memory cell response. Zloza et al . now report that these CD4-unhelped CD8 +…”
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HIV Infection Leads to Redistribution of Leaky Claudin-2 in the Intestine of Humanized SCID IL-2R(-/-) Hu-PBMC Mice by Zhang, Yong-guo, Wu, Shaoping, Lu, Rong, Richards, Maureen H, Huelsmann, Erica J, Lacek, Andrew T, Nabatiyan, Arman, Chen, Di, Al-Harthi, Lena, Zloza, Andrew, Sun, Jun

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Tu1692 HIV Infection Accelerates Gastrointestinal Tumor Outgrowth in Humanized NSG-HuPBL Mice by Lu, Rong, Wu, Shaoping, Zhang, Yong-guo, Xia, Yinglin, Huelsmann, Erica J, Lacek, Andrew T, Nabatiyan, Arman S, Richards, Maureen H, Narasipura, Srinivasa, Lutgen, Victoria, Chen, Honglei, Kaufman, Howard L, Chen, Di, Al-Harthi, Lena, Zloza, Andrew, Sun, Jun

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HIV infection accelerates gastrointestinal tumor outgrowth in NSG-HuPBL mice by Lu, Rong, Wu, Shaoping, Zhang, Yongguo, Xia, Yinglin, Huelsmann, Erica J, Lacek, Andrew T, Nabatiyan, Arman, Richards, Maureen H, Narasipura, Srinivas D, Lutgen, Victoria, Chen, Honglei, Kaufman, Howard L, Chen, Di, Al-Harthi, Lena, Zloza, Andrew, Sun, Jun

“…HIV infection is a risk factor for the tumorigenesis including non-AIDS-defining cancers such as those of the gastrointestinal tract. However, the mechanisms…”
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Development of tumor-infiltrating CD8+ T cell memory precursor effector cells and antimelanoma memory responses are the result of vaccination and TGF-β blockade during the perioperative period of tumor resection by Bellavance, Emily C, Kohlhapp, Frederick J, Zloza, Andrew, O'Sullivan, Jeremy A, McCracken, James, Jagoda, Michael C, Lacek, Andrew T, Posner, Mitchell C, Guevara-Patino, Jose A

“…A main goal of cancer immunology research is the formation of Ag-specific memory T cell immunity capable of activation upon tumor re-encounter. The…”
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CD8(+) T cells sabotage their own memory potential through IFN-γ-dependent modification of the IL-12/IL-15 receptor α axis on dendritic cells by Kohlhapp, Frederick J, Zloza, Andrew, O'Sullivan, Jeremy A, Moore, Tamson V, Lacek, Andrew T, Jagoda, Michael C, McCracken, James, Cole, David J, Guevara-Patiño, José A

“…CD8(+) T cell responses have been shown to be regulated by dendritic cells (DCs) and CD4(+) T cells, leading to the tenet that CD8(+) T cells play a passive…”
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CD8 Co-receptor promotes susceptibility of CD8⁺ T cells to transforming growth factor-β (TGF-β)-mediated suppression by Zloza, Andrew, Jagoda, Michael C, Lyons, Gretchen E, Graves, Michael C, Kohlhapp, Frederick J, O'Sullivan, Jeremy A, Lacek, Andrew T, Nishimura, Michael I, Guevara-Patiño, José A

“…CD8⁺ T cell function depends on a finely orchestrated balance of activation/suppression signals. While the stimulatory role of the CD8 co-receptor and…”
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Priming with very low-affinity peptide ligands gives rise to CD8+ T-cell effectors with enhanced function but with greater susceptibility to transforming growth factor (TGF)β-mediated suppression by O’Sullivan, Jeremy A., Zloza, Andrew, Kohlhapp, Frederick J., Moore, Tamson V., Lacek, Andrew T., Dulin, Nickolai O., Guevara-Patiño, José A.

“…While the effects of TCR affinity and TGFβ on CD8 + T-cell function have been studied individually, the manner in which TCR affinity dictates susceptibility to…”
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Engagement of NK receptor NKG2D, but not 2B4, results in self-reactive CD8+T cells and autoimmune vitiligo by Zloza, Andrew, Lyons, Gretchen E., Chlewicki, Lukasz K., Kohlhapp, Frederick J., O'sullivan, Jeremy A., Lacek, Andrew T., Moore, Tamson V., Jagoda, Michael C., Kumar, Vinay, Guevara-Patiño, José A.

“…In this study, we demonstrate that engagement of two different natural killer receptors (NKRs) can lead to contrasting effects in the development of…”
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CD8+ T cells Sabotage their own Memory Potential through IFN-γ-dependent modification of the IL-12/IL-15Rα axis on Dendritic Cells by Kohlhapp, Frederick J., Zloza, Andrew, O’Sullivan, Jeremy A., Moore, Tamson V., Lacek, Andrew T., Jagoda, Michael C., McCracken, James, Cole, David J., Guevara-Patiño, José A.

“…CD8+ T cell responses have been shown to be regulated by dendritic cells (DCs) and CD4+ T cells leading to the tenet that CD8+ T cells play a passive role in…”
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Development of Tumor-infiltrating CD8+ T cell Memory Precursor Effector Cells (MPECs) and Anti-melanoma Memory Responses are the Result of Vaccination and TGF-β Blockade During the Perioperative Period of Tumor Resection by Bellavance, Emily C., Kohlhapp, Frederick J., Zloza, Andrew, O’Sullivan, Jeremy A., McCracken, James, Jagoda, Michael C., Lacek, Andrew T., Posner, Mitchell C., Guevara-Patino, Jose A.

“…A main goal of cancer immunology research is the formation of antigen-specific memory T cell immunity capable of activation upon tumor re-encounter. The…”
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Priming with very low-affinity peptide ligands gives rise to CD8 super(+) T-cell effectors with enhanced function but with greater susceptibility to transforming growth factor (TGF) beta -mediated suppression by O'Sullivan, Jeremy A, Zloza, Andrew, Kohlhapp, Frederick J, Moore, Tamson V, Lacek, Andrew T, Dulin, Nickolai O, Guevara-Patino, Jose A

“…While the effects of TCR affinity and TGF beta on CD8 super(+) T-cell function have been studied individually, the manner in which TCR affinity dictates…”
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Priming with very low-affinity peptide ligands gives rise to CD8^sup +^ T-cell effectors with enhanced function but with greater susceptibility to transforming growth factor (TGF)[beta]-mediated suppression by O'sullivan, Jeremy A, Zloza, Andrew, Kohlhapp, Frederick J, Moore, Tamson V, Lacek, Andrew T, Dulin, Nickolai O, Guevara-patiño, José A

“…While the effects of TCR affinity and TGFβ on CD8^sup +^ T-cell function have been studied individually, the manner in which TCR affinity dictates…”
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NKG2D signaling on CD8 super(+) T cells represses T-bet and rescues CD4-unhelped CD8 super(+) T cell memory recall but not effector responses by Zloza, Andrew, Kohlhapp, Frederick J, Lyons, Gretchen E, Schenkel, Jason M, Moore, Tamson V, Lacek, Andrew T, O'Sullivan, Jeremy A, Varanasi, Vineeth, Williams, Jesse W, Jagoda, Michael C, Bellavance, Emily C, Marzo, Amanda L, Thomas, Paul G, Zafirova, Biljana, Polic, Bojan, Al-Harthi, Lena, Sperling, Anne I, Guevara-Patino, Jose A

“…CD4-unhelped CD8 super(+) T cells are functionally defective T cells primed in the absence of CD4 super(+) T cell help. Given the co-stimulatory role of…”
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CD8 Co-receptor promotes susceptibility of CD8^sup +^ T cells to transforming growth factor-[beta] (TGF-[beta])-mediated suppression by Zloza, Andrew, Jagoda, Michael C, Lyons, Gretchen E, Graves, Michael C, Kohlhapp, Frederick J, O'sullivan, Jeremy A, Lacek, Andrew T, Nishimura, Michael I, Guevara-patiño, José A

“…CD8^sup +^ T cell function depends on a finely orchestrated balance of activation/suppression signals. While the stimulatory role of the CD8 co-receptor and…”
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CD8 Co-receptor promotes susceptibility of CD8 super(+) T cells to transforming growth factor- beta (TGF- beta )-mediated suppression by Zloza, Andrew, Jagoda, Michael C, Lyons, Gretchen E, Graves, Michael C, Kohlhapp, Frederick J, O'Sullivan, Jeremy A, Lacek, Andrew T, Nishimura, Michael I, Guevara-Patino, Jose A

“…CD8 super(+) T cell function depends on a finely orchestrated balance of activation/suppression signals. While the stimulatory role of the CD8 co-receptor and…”
Get full text