Search Results - "Lacave, A J"

Recurrent Epithelial Ovarian Carcinoma: A Randomized Phase III Study of Pegylated Liposomal Doxorubicin Versus Topotecan by GORDON, Alan N, FLEAGLE, John T, GUTHRIE, David, PARKIN, David E, GORE, Martin E, LACAVE, Angel J

“…To compare the efficacy and safety of pegylated liposomal doxorubicin (PLD) and topotecan in patients with epithelial ovarian carcinoma that recurred after or…”
Get full text

Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer: results of a large European phase II study by Creemers, G J, Bolis, G, Gore, M, Scarfone, G, Lacave, A J, Guastalla, J P, Despax, R, Favalli, G, Kreinberg, R, Van Belle, S, Hudson, I, Verweij, J, Ten Bokkel Huinink, W W

“…Topotecan is a topoisomerase I inhibitor with preclinical activity against various tumor types. We conducted a large multicenter phase II study with topotecan…”
Get more information

Randomised phase II study of cisplatin and 5-fluorouracil (5-FU) versus cisplatin alone in advanced squamous cell oesophageal cancer by Bleiberg, H, Conroy, T, Paillot, B, Lacave, A.J, Blijham, G, Jacob, J.H, Bedenne, L, Namer, M, De Besi, P, Gay, F, Collette, L, Sahmoud, T

“…Patients with measurable or evaluable locally advanced or metastatic squamous cell carcinoma of the oesophagus were treated with cisplatin (CDDP), 100 mg/m 2,…”
Get full text

Final Results of a Randomized Phase III Trial of Sequential High-Dose Methotrexate, Fluorouracil, and Doxorubicin Versus Etoposide, Leucovorin, and Fluorouracil Versus Infusional Fluorouracil and Cisplatin in Advanced Gastric Cancer: A Trial of the European Organization for Research and Treatment of Cancer Gastrointestinal Tract Cancer Cooperative Group by VANHOEFER, U, ROUGIER, P, BODENSTEIN, H, SCHMOLL, H.-J, BLEIBERG, H, NORDLINGER, B, COUVREUR, M.-L, BARON, B, WILS, J. A, WILKE, H, DUCREUX, M. P, LACAVE, A. J, VAN CUTSEM, E, PLANKER, M, DOS SANTOS, J. G, PIEDBOIS, P, PAILLOT, B

“…To compare the efficacy and tolerability of etoposide, leucovorin, and bolus fluorouracil (ELF) or infusional fluorouracil plus cisplatin (FUP) with that of…”
Get full text

Doxorubicin versus doxorubicin and cisplatin in endometrial carcinoma: definitive results of a randomised study (55872) by the EORTC Gynaecological Cancer Group by Aapro, M. S., van Wijk, F. H., Bolis, G., Chevallier, B., van der Burg, M. E. L., Poveda, A., de Oliveira, C. F., Tumolo, S., Scotto di Palumbo, V., Piccart, M., Franchi, M., Zanaboni, F., Lacave, A. J., Fontanelli, R., Favalli, G., Zola, P., Guastalla, J. P., Rosso, R., Marth, C., Nooij, M., Presti, M., Scarabelli, C., Splinter, T. A. W., Ploch, E., Beex, L. V. A., ten Bokkel Huinink, W., Forni, M., Melpignano, M., Blake, P., Kerbrat, P., Mendiola, C., Cervantes, A., Goupil, A., Harper, P. G., Madronal, C., Namer, M., Scarfone, G., Stoot, J. E. G. M., Teodorovic, I., Coens, C., Vergote, I., Vermorken, J. B.

“…Background: Combination chemotherapy yields better response rates which do not always lead to a survival advantage. The aim of this study was to investigate…”
Get full text

Prospective randomised phase II study of docetaxel versus paclitaxel administered weekly in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy by Esteban, E., González de Sande, L., Fernández, Y., Corral, N., Fra, J, Muñiz, I., Vieitez, J. M., Palacio, I., Fernández, J. L., Estrada, E., Lacave, A. J.

“…Background: Docetaxel and paclitaxel have activity in the second-line treatment of non-small-cell lung cancer (NSCLC), and can be administered as weekly…”
Get full text

Cisplatin, doxorubicin and ifosfamide in carcinosarcoma of the female genital tract. A phase II study of the European Organization for Research and Treatment of Cancer Gynaecological Cancer Group (EORTC 55923) by van Rijswijk, R.E.N., Vermorken, J.B., Reed, N., Favalli, G., Mendiola, C., Zanaboni, F., Mangili, G., Vergote, I., Guastalla, J.P., ten Bokkel Huinink, W.W., Lacave, A.J., Bonnefoi, H., Tumulo, S., Rietbroek, R., Teodorovic, I., Coens, C., Pecorelli, S.

“…Carcinosarcomas of the female genital tract are highly malignant tumours composed of carcinomatous and sarcomatous elements. In the past, these tumours were…”
Get full text

Randomized phase III trial of bleomycin, vindesine, mitomycin-C, and cisplatin (BEMP) versus cisplatin (P) in disseminated squamous-cell carcinoma of the uterine cervix: An EORTC Gynecological Cancer Cooperative Group study by Vermorken, J. B., Zanetta, G., De Oliveira, C. F., van der Burg, M. E. L., Lacave, A. J., Teodorovic, I., Boes, G. Hoctin, Colombo, N.

“…Purpose: Three previous mitomycin-cisplatin-based chemotherapy trials conducted within the EORTC Gynecological Cancer Cooperative Group (GCCG) in patients with…”
Get full text

Bleomycin, Methotrexate, and CCNU in Locally Advanced or Recurrent, Inoperable, Squamous-Cell Carcinoma of the Vulva: An EORTC Gynaecological Cancer Cooperative Group Study by Wagenaar, H.C., Colombo, N., Vergote, I., Hoctin-Boes, G., Zanetta, G., Pecorelli, S., Lacave, A.J., van Hoesel, Q., Cervantes, A., Bolis, G., Namer, M., Lhommé, C., Guastalla, J.P., Nooij, M.A., Poveda, A., Scotto di Palumbo, V., Vermorken, J.B.

“…Objectives. To investigate tumor response rate and treatment toxicity of a modified combination chemotherapy consisting of bleomycin (B), methotrexate (M), and…”
Get full text

Phase II study of mitomycin-C and cisplatin in disseminated, squamous cell carcinoma of the uterine cervix. A European Organization for Research and Treatment of Cancer (EORTC) Gynecological Cancer Group study by Wagenaar, H.C., Pecorelli, S., Mangioni, C., van der Burg, M.E.L., Rotmensz, N., Anastasopoulou, A., Zola, P., Veenhof, C.H.N., Lacave, A.J., Neijt, J.P., van Oosterom, A.T., Einhorn, N., Vermorken, J.B.

“…The aim of this study was to investigate the tumour response rate and toxicity of a combination chemotherapy consisting of mitomycin-C and cisplatin in…”
Get full text

Combination of docetaxel, epirubicin and vinorelbine administered every 2 weeks as first-line therapy in patients with metastatic breast cancer: a dose-finding study by ESTEBAN, Emilio, MODOLLEL, Antonio, ESTRADA, Enrique, LACAVE, A. J, GONZALEZ DE SANDE, Luis, PALACIO, Isabel, MUNIZ, Isabel, FERNANDEZ, Yolanda, CORRAL, Norberto, FRA, Joaquin, SALA, Marian, VIEITEZ, Jose Maria

“…To assess efficacy and optimum combination dosage of intravenous docetaxel (T), epirubicin (E) and vinorelbine (N) administered every 2 weeks and without…”
Get full text

Long-term biomonitoring of breast cancer patients under adjuvant chemotherapy: the comet assay as a possible predictive factor by Uriol, E, Sierra, M, Comendador, M A, Fra, J, Martínez-Camblor, P, Lacave, A J, Sierra, L M

“…Most chemotherapy treatments induce DNA damage in the exposed patients. Using the comet assay and peripheral blood mononuclear cells (PBMC), we have quantified…”
Get full text

Phase II study of carboplatin and 1-h intravenous etoposide and paclitaxel in a novel sequence as first-line treatment of patients with small-cell lung cancer by Vieitez, J.M, Valladares, M, Gracia, M, Gonzalez-Barón, M, Martı́n, G, Mel, J.R, Rodrı́guez, R, Constenla, M, Gómez Aldavarı́, J.L, Domı́nguez, S, Dorta, J, Garcı́a-Girón, C, López, R, Sevilla, I, Esteban, E, Antón, L.M, Peláez, I, López, E, Lacave, A.J

“…Purpose: To evaluate the efficacy and tolerability of paclitaxel, carboplatin and etoposide when administered in combination to previously-untreated small-cell…”
Get full text

Phase III trial of cyclophosphamide, epirubicin, fluorouracil (CEF) versus cyclophosphamide, mitoxantrone, fluorouracil (CNF) in women with metastatic breast cancer by ESTEBAN, E, LACAVE, A. J, FERNANDEZ, J. L, CORRAL, N, BUESA, J. M, ESTRADA, E, PALACIO, I, VIEITEZ, J. M, MUNIZ, I, ALVAREZ, E

“…The mitoxantrone combination CNF and the epirubicin combination CEF have shown similar activity and less toxicity than the standard CAF combination in…”
Get full text

A phase II trial of cyclophosphamide, epirubicin and vinorelbine in the treatment of advanced breast cancer by ESTEBAN, E, DE SANDE, Gonzalez, SALA, M, LACAVE, A. J, PUERTAS, J, FRA, J, PALACIO, I, VIEITEZ, J. M, FERNANDEZ, J. L, MUNIZ, I, MODOLLEL, A, CARRASCO, J

“…Vinorelbine (Navelbin; N) has proven to be active in patients with advanced breast cancer (ABC) and cyclophosphamide (C) and epirubicin (Epiadriamycin: E) are…”
Get full text

Mitoxantrone in metastatic apudomas: a phase II study of the EORTC Gastro-Intestinal Cancer Cooperative Group by NEIJT, J. P, LACAVE, A. J, SPLINTER, T. A. W, TAAL, B. G, VEENHOF, C. H. N, SAHMOUD, T, LIPS, C. J. M

“…We performed a phase II study with mitoxantrone in patients with carcinoid tumours, islet cell tumours and medullary carcinomas of the thyroid. Thirty-five…”
Get full text

D-TRP-6-LHRH (Triptorelin) is not effective in ovarian carcinoma: an EORTC Gynaecological Cancer Co-operative Group Study by Duffaud, F, van der Burg, M EL, Namer, M, Vergote, I, Willemse, P B, ten Bokkel Huinink, W, Guastalla, J P, Nooij, M A, Kerbrat, P, Piccart, M, Tumolo, S, Favalli, G, van der Vange, N, Lacave, A J, Wils, J, Splinter, T AW, Einhorn, N, Roozendaal, K J, Rosso, R, Vermorken, J B

“…Between March and September 1988, 74 patients with progressive ovarian cancer after prior platinum-based therapy were treated with the luteinizing…”
Get full text

The Effect of Debulking Surgery after Induction Chemotherapy on the Prognosis in Advanced Epithelial Ovarian Cancer by van der Burg, Maria E.L, van Lent, Mat, Buyse, Marc, Kobierska, Anna, Colombo, Nicoletta, Favalli, Giuseppe, Lacave, Angel J, Nardi, Mario, Renard, Josette, Pecorelli, Sergio

“…The value of cytoreductive surgery in the management of ovarian cancer has been debated for years. The reasons for cytoreductive surgery are manifold. Large…”
Get full text

Bleomycin, methotrexate, and CCNU in advanced inoperable squamous cell carcinoma of the vulva: a phase II study of the EORTC Gynaecological Cancer Cooperative Group (GCCG) by Durrant, K R, Mangioni, C, Lacave, A J, George, M, van der Burg, M E, Guthrie, D, Rotmenz, N, Dalesio, O, Vermorken, J B

Get more information

Oxaliplatin or Paclitaxel in Patients With Platinum-Pretreated Advanced Ovarian Cancer: A Randomized Phase II Study of the European Organization for Research and Treatment of Cancer Gynecology Group by PICCART, M. J, GREEN, J. A, VAN GLABBEKE, M, LACOMBE, D, PINEL, M.-C, PECORELLI, S, JIMENEZ LACAVE, A, REED, N, VERGOTE, I, BENEDETTI-PANICI, P, BONETTI, A, KRISTELLER-TOME, V, MENDIOLA FERNANDEZ, C, CURRAN, D

“…This was a multicentric, open, randomized, phase II study of single-agent paclitaxel and oxaliplatin to evaluate the efficacy of oxaliplatin in a relapsing…”
Get full text