Search Results - "Lacagnina, Michael J"

Optimized solubilization of TRIzol-precipitated protein permits Western blotting analysis to maximize data available from brain tissue by Kopec, Ashley M., Rivera, Phillip D., Lacagnina, Michael J., Hanamsagar, Richa, Bilbo, Staci D.

“…•Optimized lysis buffer increases solubilization of TRIzol-precipitated protein.•Solubilization is effective with a wide range of incubation times and…”
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Autoimmune regulation of chronic pain by Lacagnina, Michael J., Heijnen, Cobi J., Watkins, Linda R., Grace, Peter M.

“…Chronic pain is an unpleasant and debilitating condition that is often poorly managed by existing therapeutics. Reciprocal interactions between the nervous…”
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Toll-like receptors and their role in persistent pain by Lacagnina, Michael J., Watkins, Linda R., Grace, Peter M.

“…One of the fundamental mechanisms whereby the innate immune system coordinates inflammatory signal transduction is through Toll-like receptors (TLRs), which…”
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Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse by Lacagnina, Michael J, Rivera, Phillip D, Bilbo, Staci D

“…Drugs of abuse cause persistent alterations in synaptic plasticity that may underlie addiction behaviors. Evidence suggests glial cells have an essential and…”
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A rat model to investigate quality of recovery after abdominal surgery by Cata, Juan P, Patiño, Miguel, Lacagnina, Michael J, Li, Jiahe, Gorur, Aysegul, Agudelo-Jimenez, Ruben, Wei, Bo, Hagberg, Carin A, Dougherty, Patrick M, Shureiqi, Imad, Yang, Peiying, Grace, Peter M

“…Major advances in therapies to optimize recovery after surgery have been limited by the lack of an animal model that can mimic major domains of postoperative…”
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Oral Dimethyl Fumarate Reduces Peripheral Neuropathic Pain in Rodents via NFE2L2 Antioxidant Signaling by Li, Jiahe, Ma, Jiacheng, Lacagnina, Michael J., Lorca, Sabina, Odem, Max A., Walters, Edgar T., Kavelaars, Annemieke, Grace, Peter M.

“…WHAT WE ALREADY KNOW ABOUT THIS TOPICOxidative stress is an important driver of neuropathic painDimethyl fumarate activates nuclear factor erythroid 2-related…”
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Oral Dimethyl Fumarate Reduces Peripheral Neuropathic Pain in Rodents via NFE2L2 Antioxidant Signaling by Li, Jiahe, Ma, Jiacheng, Lacagnina, Michael J, Lorca, Sabina, Odem, Max A, Walters, Edgar T, Kavelaars, Annemieke, Grace, Peter M

“…Available treatments for neuropathic pain have modest efficacy and significant adverse effects, including abuse potential. Because oxidative stress is a key…”
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The role of cytokines in acute and chronic postsurgical pain after major musculoskeletal surgeries in a quaternary pediatric center by Chidambaran, Vidya, Duan, Qing, Pilipenko, Valentina, Glynn, Susan M., Sproles, Alyssa, Martin, Lisa J., Lacagnina, Michael J., King, Christopher D., Ding, Lili

“…•Pro-inflammatory cytokines are associated with increased acute postoperative pain.•IL-6, IL-8, and IL-13 are protective for CPSP.•Cytokine contributions to…”
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Sham surgeries for central and peripheral neural injuries persistently enhance pain-avoidance behavior as revealed by an operant conflict test by Odem, Max A., Lacagnina, Michael J., Katzen, Stephen L., Li, Jiahe, Spence, Emily A., Grace, Peter M., Walters, Edgar T.

“…Studies using rodent models of neuropathic pain use sham surgery control procedures that cause deep tissue damage. Sham surgeries would thus be expected to…”
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A role for neuroimmune signaling in a rat model of Gulf War Illness-related pain by Lacagnina, Michael J., Li, Jiahe, Lorca, Sabina, Rice, Kenner C., Sullivan, Kimberly, O'Callaghan, James P., Grace, Peter M.

“…•A neuroinflammatory basis for pain associated with GWI has not been investigated.•Combination Gulf War-relevant exposures induce long-lasting musculoskeletal…”
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Preconditioning by voluntary wheel running attenuates later neuropathic pain via nuclear factor E2–related factor 2 antioxidant signaling in rats by Green-Fulgham, Suzanne M., Harland, Michael E., Ball, Jayson B., Li, Jiahe, Lacagnina, Michael J., D'Angelo, Heather, Dreher, Renee A., Willcox, Kendal F., Lorca, Sabina A., Kwilasz, Andrew J., Maier, Steven F., Watkins, Linda R., Grace, Peter M.

“…Animal and human studies have shown that exercise prior to nerve injury prevents later chronic pain, but the mechanisms of such preconditioning remain elusive…”
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Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats by Lacagnina, Michael J, Kopec, Ashley M, Cox, Stewart S, Hanamsagar, Richa, Wells, Corinne, Slade, Susan, Grace, Peter M, Watkins, Linda R, Levin, Edward D, Bilbo, Staci D

“…Early-life conditions can contribute to the propensity for developing neuropsychiatric disease, including substance abuse disorders. However, the long-lasting…”
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Voluntary wheel running prevents formation of membrane attack complexes and myelin degradation after peripheral nerve injury by Green-Fulgham, Suzanne M, Lacagnina, Michael J, Willcox, Kendal F, Li, Jiahe, Harland, Michael E, Ciena, Adriano Polican, Rocha, Igor R Correia, Ball, Jayson B, Dreher, Renee A, Zuberi, Younus A, Dragavon, Joseph M, Chacur, Marucia, Maier, Steven F, Watkins, Linda R, Grace, Peter M

“…Regular aerobic activity is associated with a reduced risk of chronic pain in humans and rodents. Our previous studies in rodents have shown that prior…”
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B cells drive neuropathic pain-related behaviors in mice through IgG-Fc gamma receptor signaling by Lacagnina, Michael J, Willcox, Kendal F, Boukelmoune, Nabila, Bavencoffe, Alexis, Sankaranarayanan, Ishwarya, Barratt, Daniel T, Zuberi, Younus A, Dayani, Dorsa, Chavez, Melissa V, Lu, Jonathan T, Farinotti, Alex Bersellini, Shiers, Stephanie, Barry, Allison M, Mwirigi, Juliet M, Tavares-Ferreira, Diana, Funk, Geoffrey A, Cervantes, Anna M, Svensson, Camilla I, Walters, Edgar T, Hutchinson, Mark R, Heijnen, Cobi J, Price, Theodore J, Fiore, Nathan T, Grace, Peter M

“…Neuroimmune interactions are essential for the development of neuropathic pain, yet the contributions of distinct immune cell populations have not been fully…”
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Sensitized activation of Fos and brain-derived neurotrophic factor in the medial prefrontal cortex and ventral tegmental area accompanies behavioral sensitization to amphetamine by Fanous, Sanya, Lacagnina, Michael J., Nikulina, Ella M., Hammer, Ronald P.

“…Behavioral sensitization, or augmented locomotor response to successive drug exposures, results from neuroadaptive changes contributing to addiction. Both the…”
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Experience-dependent effects of context and restraint stress on corticolimbic c-Fos expression by Hoffman, Ann N, Anouti, Danya P, Lacagnina, Michael J, Nikulina, Ella M, Hammer, Jr, Ronald P, Conrad, Cheryl D

“…Stressors are typically multidimensional, comprised of multiple physical and sensory components that rarely occur as single isolated events. This study used a…”
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Development of a High-Throughput Drug Screening System Based on Human Peripheral Blood Derived Microglia-like Cells from Sickle Cell Patients with Chronic Pain by Zhang, Yankai, Kanne, Celeste K., Lacagnina, Michael J., Grace, Peter M., Burish, Mark J., Sheehan, Vivien A.

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Functionality of a Peripheral Blood Derived Microglia-like Cell System for Drug Discovery to Treat Sickle Cell Related Chronic Pain by Zhang, Yankai, Kanne, Celeste K., Hernandez, Britney N., Lacagnina, Michael J., Grace, Peter M., Burish, Mark J., Sheehan, Vivien A.

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Validation of a Peripheral Blood-Derived Microglia-like Cell System by Zhang, Yankai, Kanne, Celeste K., Tran, Jennifer N., Lacagnina, Michael J., Grace, Peter M., Burish, Mark J., Sheehan, Vivien A.

“…Background: Individuals with chronic pain may have hyperactive microglia, which stimulate neurons to send a pain signal with little or no stimuli. Microglia…”
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Site-specific drug release of monomethyl fumarate to treat oxidative stress disorders by Avery, Thomas D., Li, Jiahe, Turner, Dion J. L., Rasheed, Mohd S. U., Cherry, Fisher R., Stachura, Damian L., Rivera-Escalera, Fátima, Ruiz, David M., Lacagnina, Michael J., Gaffney, Caitlyn M., Aguilar, Clarissa, Yu, Jingxian, Wang, Yang, Xie, Huan, Liang, Dong, Shepherd, Andrew J., Abell, Andrew D., Grace, Peter M.

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