Search Results - "Labus, Josephine"

Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix by Bijata, Monika, Labus, Josephine, Guseva, Daria, Stawarski, Michał, Butzlaff, Malte, Dzwonek, Joanna, Schneeberg, Jenny, Böhm, Katrin, Michaluk, Piotr, Rusakov, Dmitri A., Dityatev, Alexander, Wilczyński, Grzegorz, Wlodarczyk, Jakub, Ponimaskin, Evgeni

“…Rewiring of synaptic circuitry pertinent to memory formation has been associated with morphological changes in dendritic spines and with extracellular matrix…”
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Palmitoylation of the small GTPase Cdc42 by DHHC5 modulates spine formation and gene transcription by Wirth, Alexander, Labus, Josephine, Abdel Galil, Dalia, Schill, Yvonne, Schmidt, Silke, Bunke, Tania, Gorinski, Nataliya, Yokoi, Norihiko, Fukata, Masaki, Ponimaskin, Evgeni

“…The small GTPase Cdc42 exists in the form of two alternatively spliced variants that are modified by hydrophobic chains: the ubiquitously expressed…”
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Circulating miR-133a-3p defines a low-risk subphenotype in patients with heart failure and central sleep apnea: a decision tree machine learning approach by de Gonzalo-Calvo, David, Martinez-Camblor, Pablo, Belmonte, Thalia, Barbé, Ferran, Duarte, Kevin, Cowie, Martin R., Angermann, Christiane E., Korte, Andrea, Riedel, Isabelle, Labus, Josephine, Koenig, Wolfgang, Zannad, Faiez, Thum, Thomas, Bär, Christian

“…Background Patients with heart failure with reduced ejection fraction (HFrEF) and central sleep apnea (CSA) are at a very high risk of fatal outcomes…”
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Structural determinants for activation of the Tau kinase CDK5 by the serotonin receptor 5-HT7R by Ackmann, Jana, Brüge, Alina, Gotina, Lizaveta, Lim, Sungsu, Jahreis, Kathrin, Vollbrecht, Anna-Lena, Kim, Yun Kyung, Pae, Ae Nim, Labus, Josephine, Ponimaskin, Evgeni

“…Multiple neurodegenerative diseases are induced by the formation and deposition of protein aggregates. In particular, the microtubule-associated protein Tau…”
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Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior by Bijata, Monika, Bączyńska, Ewa, Müller, Franziska E., Bijata, Krystian, Masternak, Julia, Krzystyniak, Adam, Szewczyk, Bernadeta, Siwiec, Marcin, Antoniuk, Svitlana, Roszkowska, Matylda, Figiel, Izabela, Magnowska, Marta, Olszyński, Krzysztof H., Wardak, Agnieszka D., Hogendorf, Adam, Ruszczycki, Błażej, Gorinski, Nataliya, Labus, Josephine, Stępień, Tomasz, Tarka, Sylwia, Bojarski, Andrzej J., Tokarski, Krzysztof, Filipkowski, Robert K., Ponimaskin, Evgeni, Wlodarczyk, Jakub

“…Major depressive disorder is a complex disease resulting from aberrant synaptic plasticity that may be caused by abnormal serotonergic signaling. Using a…”
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CD44 regulates dendrite morphogenesis through Src tyrosine kinase-dependent positioning of the Golgi apparatus by Skupien, Anna, Konopka, Anna, Trzaskoma, Paweł, Labus, Josephine, Gorlewicz, Adam, Swiech, Lukasz, Babraj, Matylda, Dolezyczek, Hubert, Figiel, Izabela, Ponimaskin, Evgeni, Wlodarczyk, Jakub, Jaworski, Jacek, Wilczynski, Grzegorz M., Dzwonek, Joanna

“…The acquisition of proper dendrite morphology is a critical aspect of neuronal development toward the formation of a functional network. The role of the…”
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Interleukin-1β induces an inflammatory response and the breakdown of the endothelial cell layer in an improved human THBMEC-based in vitro blood–brain barrier model by Labus, Josephine, Häckel, Sonja, Lucka, Lother, Danker, Kerstin

“…•A blood–brain barrier model based on the THBMEC cell line was improved.•A novel inflammatory blood–brain barrier model was established.•IL-1β induced a strong…”
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IL-1β promotes transendothelial migration of PBMCs by upregulation of the FN/α5β1 signalling pathway in immortalised human brain microvascular endothelial cells by Labus, Josephine, Wöltje, Kerstin, Stolte, Kim Natalie, Häckel, Sonja, Kim, Kwang Sik, Hildmann, Annette, Danker, Kerstin

“…Neuroinflammation is often associated with pathological changes in the function of the blood-brain barrier (BBB) caused by disassembly of tight and adherens…”
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The α1 integrin cytoplasmic tail interacts with phosphoinositides and interferes with Akt activation by Labus, Josephine, Tang, Kerstin, Henklein, Petra, Krüger, Ulrike, Hofmann, Andreas, Hondke, Sylvia, Wöltje, Kerstin, Freund, Christian, Lucka, Lothar, Danker, Kerstin

“…Integrin α1β1 is an adhesion receptor that binds to collagen and laminin. It regulates cell adhesion, cytoskeletal organization, and migration. The cytoplasmic…”
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Serotonin 5‐HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons by Speranza, Luisa, Labus, Josephine, Volpicelli, Floriana, Guseva, Daria, Lacivita, Enza, Leopoldo, Marcello, Bellenchi, Gian Carlo, Porzio, Umberto, Bijata, Monika, Perrone‐Capano, Carla, Ponimaskin, Evgeni

“…Precise control of dendritic spine density and synapse formation is critical for normal and pathological brain functions. Therefore, signaling pathways…”
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Circulating long noncoding RNA PDE4DIPP6: A novel biomarker for improving the clinical management of non-ST-segment elevation myocardial infarction by Koch, Pia F., García-Hidalgo, María C., Labus, Josephine, Biener, Moritz, Thum, Thomas, de Gonzalo-Calvo, David, Bär, Christian

“…•What is already known:•Hs-cTnT assays exhibit remarkable sensitivity but often compromise specificity.•Augmenting hs-cTnT with supplementary parameters is…”
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The cell adhesion molecule CD44 acts as a modulator of 5-HT7 receptor functions by Borsdorf, Saskia, Zeug, Andre, Wu, Yuxin, Mitroshina, Elena, Vedunova, Maria, Gaitonde, Supriya A, Bouvier, Michel, Wehr, Michael C, Labus, Josephine, Ponimaskin, Evgeni

“…Homo- and heteromerization of G protein-coupled receptors (GPCRs) plays an important role in the regulation of receptor functions. Recently, we demonstrated an…”
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Amelioration of Tau pathology and memory deficits by targeting 5-HT7 receptor by Labus, Josephine, Röhrs, Kian-Fritz, Ackmann, Jana, Varbanov, Hristo, Müller, Franziska E., Jia, Shaobo, Jahreis, Kathrin, Vollbrecht, Anna-Lena, Butzlaff, Malte, Schill, Yvonne, Guseva, Daria, Böhm, Katrin, Kaushik, Rahul, Bijata, Monika, Marin, Philippe, Chaumont-Dubel, Séverine, Zeug, Andre, Dityatev, Alexander, Ponimaskin, Evgeni

“…•Constitutive 5-HT7R activity rises pathological Tau phosphorylation and aggregation.•5-HT7R modulates Tau phosphorylation via CDK5 in Gprotein-independent…”
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Amisulpride as a potential disease‐modifying drug in the treatment of tauopathies by Jahreis, Kathrin, Brüge, Alina, Borsdorf, Saskia, Müller, Franziska E., Sun, Weilun, Jia, Shaobo, Kang, Dong Min, Boesen, Nicolette, Shin, Seulgi, Lim, Sungsu, Koroleva, Anastasia, Satała, Grzegorz, Bojarski, Andrzej J., Rakuša, Elena, Fink, Anne, Doblhammer‐Reiter, Gabriele, Kim, Yun Kyung, Dityatev, Alexander, Ponimaskin, Evgeni, Labus, Josephine

“…INTRODUCTION Hyperphosphorylation and aggregation of the microtubule‐associated protein tau cause the development of tauopathies, such as Alzheimer's disease…”
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The α 1 integrin cytoplasmic tail interacts with phosphoinositides and interferes with Akt activation by Labus, Josephine, Tang, Kerstin, Henklein, Petra, Krüger, Ulrike, Hofmann, Andreas, Hondke, Sylvia, Wöltje, Kerstin, Freund, Christian, Lucka, Lothar, Danker, Kerstin

“…Integrin α β is an adhesion receptor that binds to collagen and laminin. It regulates cell adhesion, cytoskeletal organization, and migration. The cytoplasmic…”
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CD44 regulates dendrite morphogenesis through Src tyrosine kinase-dependent positioning of the Golgi by Skupien, Anna, Konopka, Anna, Trzaskoma, PaweI, Labus, Josephine, Gorlewicz, Adam, Swiech, Lukasz, Babraj, Matylda, Dolezyczek, Hubert, Figiel, Izabela, Ponimaskin, Evgeni, Wlodarczyk, Jakub, Jaworski, Jacek, Wilczynski, Grzegorz M, Dzwonek, Joanna

“…The acquisition of proper dendrite morphology is a crucial aspect of neuronal development towards the formation of a functional network. The role of the…”
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Serotonin 5‐ HT 7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons by Speranza, Luisa, Labus, Josephine, Volpicelli, Floriana, Guseva, Daria, Lacivita, Enza, Leopoldo, Marcello, Bellenchi, Gian Carlo, di Porzio, Umberto, Bijata, Monika, Perrone‐Capano, Carla, Ponimaskin, Evgeni

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IL-1β promotes transendothelial migration of PBMCs by upregulation of the FN/α 5 β 1 signalling pathway in immortalised human brain microvascular endothelial cells by Labus, Josephine, Wöltje, Kerstin, Stolte, Kim Natalie, Häckel, Sonja, Kim, Kwang Sik, Hildmann, Annette, Danker, Kerstin

“…Neuroinflammation is often associated with pathological changes in the function of the blood-brain barrier (BBB) caused by disassembly of tight and adherens…”
Get full text